Patents by Inventor Rafael Wilhelmus Elisabeth Ghislain Reintjens

Rafael Wilhelmus Elisabeth Ghislain Reintjens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10118149
    Abstract: The present invention relates to an apparatus comprising a) an unbaffled reactor or microreactor having a channel defined by a pathway, and b) an oscillating flow device, wherein the channel pathway comprises a plurality of directional changes. The reactor channel has a hydrolic diameter from 0.1 mm to 10 mm. A method of making said apparatus and the use of said apparatus to carry out a process on a suspension is also disclosed.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: November 6, 2018
    Assignee: Patheon Austria GmbH & Co KG
    Inventors: Rafael Wilhelmus Elisabeth Ghislain Reintjens, Mehul Thathagar
  • Patent number: 9550797
    Abstract: The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: January 24, 2017
    Assignee: Patheon Holdings I B.V.
    Inventors: Mehul Thathagar, Peter Poechlauer, Rafael Wilhelmus Elisabeth Ghislain Reintjens, Michel Goldbach
  • Publication number: 20160137669
    Abstract: The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.
    Type: Application
    Filed: June 27, 2014
    Publication date: May 19, 2016
    Inventors: Mehul Thathagar, Peter Poechlauer, Rafael Wilhelmus Elisabeth Ghislain Reintjens, Michel Goldbach
  • Patent number: 9249088
    Abstract: A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: February 2, 2016
    Assignee: DPx Holdings B.V.
    Inventors: Peter Poechlauer, Rafael Wilhelmus Elisabeth Ghislain Reintjens, Hubertus Johannes Adrianus Dielemans, Mehul Thathagar, Jeroen Hubertina Gerardus Konings
  • Publication number: 20140100360
    Abstract: A process for producing a reaction product of a diazo compound, which process comprises: a. continuously supplying to a first reactor a precursor of a diazo compound; a water-miscible solvent; a base and water; b. mixing the precursor of a diazo compound; the water-miscible solvent; the base and water to generate a diazo compound; c. continuously removing from the first reactor, through a hydrophobic membrane, into a second reactor the formed diazo compound; d. continuously removing from the first reactor all reaction products that have not passed into the second reactor; e. continuously supplying to the second reactor a substrate in a non-water-miscible solvent; f. mixing the above components to generate a reaction product of a diazo compound; and g. continuously removing from the second reactor the non-water-miscible solvent and the reaction product of the diazo compound, and apparatus suitable for carrying out such a process.
    Type: Application
    Filed: November 1, 2011
    Publication date: April 10, 2014
    Applicants: DSM FINE CHEMICALS AUSTRIA NFG. GMBH & CO KG, DSM IP ASSETS B.V.
    Inventors: Peter Poechlauer, Rafael Wilhelmus Elisabeth Ghislain Reintjens, Hubertus Johannes Adrianus Dielemans, Mehul Thathagar, Jeroen Hubertina Gerardus Konings
  • Publication number: 20140081038
    Abstract: The present invention relates to an apparatus comprising a) an unbaffled reactor or microreactor having a channel defined by a pathway, and b) an oscillating flow device, wherein the channel pathway comprises a plurality of directional changes. The reactor channel has a hydrolic diameter from 0.1 mm to 10 mm A method of making said apparatus and the use of said apparatus to carry out a process on a suspension is also disclosed.
    Type: Application
    Filed: January 13, 2011
    Publication date: March 20, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Rafael Wilhelmus Elisabeth Ghislain Reintjens, Mehul Thathagar
  • Patent number: 8106242
    Abstract: Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: January 31, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Rafael Wilhelmus Elisabeth Ghislain Reintjens, Quirinus Bernardus Broxterman, Martina Kotthaus, Peter Poechlauer
  • Publication number: 20100029990
    Abstract: Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.
    Type: Application
    Filed: May 23, 2007
    Publication date: February 4, 2010
    Inventors: Rafael Wilhelmus Elisabeth Ghislain Reintjens, Quirinus Bernardus Broxterman, Martina Kotthaus, Peter Poechlauer