Patents by Inventor Rahul Satija

Rahul Satija has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR COMBINATORIAL TARGETING OF THE CELL TRANSCRIPTOME
    Publication number: 20240124873
    Abstract: Provided herein are compositions comprising a CRISPR array comprising one or more crRNA sequences and a 5? direct repeat (DR) sequence linked to a barcode guide RNA (bcgRNA), wherein the bcgRNA comprises from 5? to 3? (a) a barcode sequence, and (b) a reverse-transcription handle. Also provided are methods that comprise using the described CRISPR arrays to introduce one or perturbations in a single cell transcriptome.
    Type: Application
    Filed: March 1, 2022
    Publication date: April 18, 2024
    Inventors: Neville E. Sanjana, Hans-Hermann Wessels, Alejandro Mendez-Mancilla, Rahul Satija
  • Product and methods useful for modulating and evaluating immune responses
    Patent number: 11630103
    Abstract: The present invention provides isolated immune cells, immune cell populations and compositions, as well as markers, marker signatures and molecular targets characterising the immune cells. The cell products, substances, compositions, markers, marker signatures, molecular targets, kits of parts and methods of the present invention provide for new ways to characterise, evaluate and modulate the immune system and immune responses.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: April 18, 2023
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Alexandra-Chloé Villani, Rahul Satija, Aviv Regev, Nir Hacohen
  • PRODUCT AND METHODS USEFUL FOR MODULATING AND EVALUATING IMMUNE RESPONSES
    Publication number: 20220397568
    Abstract: The present invention provides isolated immune cells, immune cell populations and compositions, as well as markers, marker signatures and molecular targets characterising the immune cells. The cell products, substances, compositions, markers, marker signatures, molecular targets, kits of parts and methods of the present invention provide for new ways to characterise, evaluate and modulate the immune system and immune responses.
    Type: Application
    Filed: August 17, 2017
    Publication date: December 15, 2022
    Inventors: Alexandra-Chloé VILLANI, Rahul SATIJA, Aviv Regev, Nir HACOHEN
  • Dendritic cell response gene expression, compositions of matters and methods of use thereof
    Patent number: 10870885
    Abstract: This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences dendritic cell (DC) response(s), for example, dendritic cell maturation, dendritic cell antiviral response(s) and/or dendritic cell inflammatory response(s), as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences dendritic cell response(s) in a variety of therapeutic and/or diagnostic indications.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: December 22, 2020
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Aviv Regev, Alexander K. Shalek, Rahul Satija, Hongkun Park
  • DENDRITIC CELL RESPONSE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF
    Publication number: 20150368719
    Abstract: This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences dendritic cell (DC) response(s), for example, dendritic cell maturation, dendritic cell antiviral response(s) and/or dendritic cell inflammatory response(s), as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences dendritic cell response(s) in a variety of therapeutic and/or diagnostic indications.
    Type: Application
    Filed: September 4, 2015
    Publication date: December 24, 2015
    Inventors: Aviv Regev, Alexander K. Shalek, Rahul Satija, Hongkun Park