Patents by Inventor Rainer Hahn
Rainer Hahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240079703Abstract: A battery module includes a module housing; and at least two battery blocks arranged within the module housing, wherein the battery blocks each include at least two energy storage elements having at least one positive electrode and at least one negative electrode, the at least two energy storage elements of one battery block are connected in series and/or in parallel; each of the battery blocks provides a maximum of 60 volts DC; the module housing has at least two positive power connection contacts and at least two negative power connection contacts connected to the battery blocks so that the DC voltages supplied by the battery blocks can be tapped from outside the module housing; and a maximum DC voltage that can be tapped between a positive and a negative power connection contact is 60 volts.Type: ApplicationFiled: December 16, 2021Publication date: March 7, 2024Inventors: Matthias Geiss, Rainer Hahn, Dieter Kloos, Roman Stübler
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Patent number: 10661264Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.Type: GrantFiled: August 14, 2018Date of Patent: May 26, 2020Assignees: BOEHRINGER INGELHEIM RCV GMBH & CO KG, SANDOZ AGInventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
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Patent number: 10537887Abstract: The present invention provides a novel adsorbent composition for recovering biomolecules from a fluid. The composition comprises positively and negatively charged microparticles in the form of ground particles. The adsorbent is particularly useful for purification of biomolecules from the cell culture.Type: GrantFiled: August 25, 2014Date of Patent: January 21, 2020Assignees: BOEHRINGER INGELHEIM RCV & GMBH CO KG, SANDOZ AGInventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov, Moritz Imendoerffer
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Publication number: 20190046969Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.Type: ApplicationFiled: August 14, 2018Publication date: February 14, 2019Inventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
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Patent number: 10076749Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.Type: GrantFiled: August 25, 2014Date of Patent: September 18, 2018Assignees: BOEHRINGER INGELHEIM RCV GMBH & CO KG, SANDOZ AGInventors: Rainer Hahn, Alois Jungbauer, Alexandru Trefilov
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Publication number: 20160340384Abstract: Disclosed is a method for refolding recombinantly produced polypeptides comprising the steps of (a)providing inclusion bodies comprising recombinantly produced polypeptides comprising the recombinantly produced polypeptides, (b)dissolving the inclusion bodies under chaotropic conditions in so as to obtain denatured recombinantly produced polypeptides, and (c)refolding the denatured recombinantly produced polypeptides inclusion bodies by addition of a refolding buffer,so as to obtain refolded re-combinantly produced polypeptides, and (d) further processing the refolded recombinantly produced polypeptides by at least one processing step, wherein at least steps (c) and (d) are performed in a tubular reactor in a continuous manner.Type: ApplicationFiled: December 22, 2014Publication date: November 24, 2016Applicant: SANDOZ AGInventors: Alois JUNGBAUER, Pan SIQI, Monika ZELGER, Rainer HAHN
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Publication number: 20160200760Abstract: The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or negatively charged microparticles comprising ground resin. It is particularly useful for purification of biomolecules from cell culture.Type: ApplicationFiled: August 25, 2014Publication date: July 14, 2016Inventors: Rainer HAHN, Alois JUNGBAUER, Alexandru TREFILOV
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Publication number: 20160193598Abstract: The present invention provides a novel adsorbent composition for recovering biomolecules from a fluid. The composition comprises positively and negatively charged microparticles in the form of ground particles. The adsorbent is particularly useful for purification of biomolecules from the cell culture.Type: ApplicationFiled: August 25, 2013Publication date: July 7, 2016Applicant: Boehringer Ingelhelim RCV GMBH & Co KGInventors: Rainer HAHN, Alois JUNGBAUER, Alexandru TREFILOV, Moritz IMENDOERFFER
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Patent number: 9248319Abstract: The present invention relates to functional composite particles for the oral care sector, more particularly for toothpastes and mouthwashes, which are charged with active ingredients which ensure a long-term antimicrobial or antibacterial effect in the oral cavity and hence reduce the formation of plaque and halitosis. The invention further relates to a process for producing these composite particles and also to their use for producing oral hygiene articles.Type: GrantFiled: August 6, 2010Date of Patent: February 2, 2016Assignee: Evonik DegussaInventors: Wojciech Pisula, Stephanie Schäffer, Juri Tschernjaew, Arnold Storeck, Rainer Hahn
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Patent number: 8372959Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprises the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein the steps are conducted on one affinity chromatography system.Type: GrantFiled: January 11, 2012Date of Patent: February 12, 2013Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KGInventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
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Publication number: 20120107869Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.Type: ApplicationFiled: January 11, 2012Publication date: May 3, 2012Applicants: BOEHRINGER INGELHEIM RCV GmbH & Co KG, SANDOZ AGInventors: Alois JUNGBAUER, Rainer Hahn, Anne Tscheliessnig, Waltraud Karr
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Patent number: 8163890Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.Type: GrantFiled: April 25, 2006Date of Patent: April 24, 2012Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KGInventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
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Patent number: 8058410Abstract: Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X1X2X3X4, wherein X1 to X4 are amino acid residues and at least two of X1 to X4 is W, Y or F; b) peptides comprising the formula X5X6X7X8, wherein X5 to X8 are amino acid residues, at least one of X5 to X8 is W, and at least one of X5 to X8 is E or D; and c) poly-amino acids consisting of an amino acid monomer of the group consisting of R, K, E and D and an amino acid monomer of the group consisting of Y, F and W, preferably poly-KY, poly-KF, poly-KW, poly-RY, poly-RF, poly-RW, poly-EY, poly-DY, poly-EF, poly-EW, poly-DF and poly-DW, with the proviso that the peptides according to a) and b) have a maximum length of 35 amino acid residues and that the poly-amino acids according to c) have a minimum length of 20 amino acid residues.Type: GrantFiled: April 25, 2006Date of Patent: November 15, 2011Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KGInventors: Alois Jungbauer, Rainer Hahn, Waltraud Kaar, Michael Seifert, Bernhard Auer, Clemens Achmüller, Philipp Wechner
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Publication number: 20110268997Abstract: A battery comprising a cell stack comprising at least one individual cell in a cell housing, an electronic component part, electrical conductors between the cell stack and the electronic component part and an injection-molded part which substantially completely surrounds the electrical conductors and is connected in form-fitting fashion both the cell stack and to the electronic component part and connects the cell stack and the electronic component part to one another, outer contact faces of the battery also being integrated in the electronic component part in addition to at least one electronic circuit.Type: ApplicationFiled: January 22, 2010Publication date: November 3, 2011Applicant: VARTA Microbattery GmbHInventors: Christian Gaugler, Kuno Gross, Rainer Hahn
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Publication number: 20110033511Abstract: The present invention relates to functional composite particles for the oral care sector, more particularly for toothpastes and mouthwashes, which are charged with active ingredients which ensure a long-term antimicrobial or antibacterial effect in the oral cavity and hence reduce the formation of plaque and halitosis. The invention further relates to a process for producing these composite particles and also to their use for producing oral hygiene articles.Type: ApplicationFiled: August 6, 2010Publication date: February 10, 2011Inventors: Wojciech Pisula, Stephanie Schäffer, Juri Tschernjaew, Arnold Storeck, Rainer Hahn
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Publication number: 20090306343Abstract: Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X1X2X3X4, wherein X1 to X4 are amino acid residues and at least two of X1 to X4 is W, Y or F; b) peptides comprising the formula X5X6X7X8, wherein X5 to X8 are amino acid residues, at least one of X5 to X8 is W, and at least one of X5 to X8 is E or D; and c) poly-amino acids consisting of an amino acid monomer of the group consisting of R, K, E and D and an amino acid monomer of the group consisting of Y, F and W, preferably poly-KY, poly-KF, poly-KW, poly-RY, poly-RF, poly-RW, poly-EY, poly-DY, poly-EF, poly-EW, poly-DF and poly-DW, with the proviso that the peptides according to a) and b) have a maximum length of 35 amino acid residues and that the poly-amino acids according to c) have a minimum length of 20 amino acid residues.Type: ApplicationFiled: April 25, 2006Publication date: December 10, 2009Inventors: Alois Jungbauer, Rainer Hahn, Waltraud Kaar, Michael Seifert, Bernhard Auer, Clemens Achmuller, Philipp Wechner
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Publication number: 20090203069Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.Type: ApplicationFiled: April 25, 2006Publication date: August 13, 2009Applicants: BOEHRINGER INGELHEIM AUSTRIA GMBH, SANDOZ AGInventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
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Patent number: 7365101Abstract: A dispersion of pyrogenically produced cerium oxide, which does not contain any particles larger than 1 ?m, is produced by dispersing a pyrogenically produced cerium oxide in water by means of a dissolver, centrifuging it, separating the supernatant from the bottom product, and again dispersing the supernatant by means of ultrasound. The dispersion can be used for chemical-mechanical polishing (CMP).Type: GrantFiled: September 15, 2004Date of Patent: April 29, 2008Assignee: Degussa AGInventors: Michael Kröll, Günther Michael, Rainer Hahn, Stipan Katusic, Stefan Heberer, Ralph Brandes
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Publication number: 20070243201Abstract: The invention relates to a method for the selection of epitopes for immunotherapy, peptides obtained by said method, the use of said peptides as vaccines and diagnostics and an immune serum obtainable by said method.Type: ApplicationFiled: June 2, 2004Publication date: October 18, 2007Applicant: Igeneon Krebs-Immuntherapie Forschungs-und entwicklungs-AGInventors: Hans Loibner, Gottfried Himmler, Alois Jungbauer, Erich Wasserbauer, Manfred Schuster, Rainer Hahn, Astrid Durauer
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Patent number: 7163397Abstract: An apparatus for applying a viscous modification material includes a material source of the modification material and a needle connected to the source. A material for selectively modifying the optical properties of cells comprises a basic material and a modification substance distributed in the basic material at a prescribed concentration, wherein the basic material comprises a viscous fluid, a gel, a two-dimensional or three-dimensional porous substrate or a material which hardens in situ. A diagnostic apparatus for determining the optical properties of cells which have been exposed to such a material and an apparatus for irradiating cells whose optical properties have been differently modified with such a material are also provided.Type: GrantFiled: January 8, 2004Date of Patent: January 16, 2007Assignee: Karl Storz GmbH & Co.Inventors: Rainer Hahn, Klaus Irion