Abstract: A method for autonomous operation of a vehicle on a driving route ahead permits autonomous operation of the vehicle is only permitted if one or a group of conditions is/are fulfilled for a predetermined route length of the driving route ahead. The conditions include: there is a structural separation on at least one side of a current travel path of the vehicle; a driving lane of the vehicle has a minimum lane width; there are no humps and dips substantially limiting the range of environmental detection sensors; the number of driving lanes does not change; there are no tunnels; there are no buildings on the travel path; there are no motorway junctions; a radius of curvature of the driving lane of the vehicle is larger than a predetermined limit value; there are no traffic disruptions; there are no traffic reports about dangerous situations; and there are no traffic reports about the presence of roadworks.