Patents by Inventor Rainer Naeff

Rainer Naeff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adduct of topiramate and tramadol hydrochloride and uses thereof
    Patent number: 7378519
    Abstract: Processes for isolation and purification of enantiomerically enriched compositions comprising tramadol and topiramate, and also for the subsequent isolation of 1S,2S-tramadol hydrochloride, are disclosed herein.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: May 27, 2008
    Assignee: Cilag GmbH International
    Inventors: Rainer Naeff, Sonja Spycher-Huber, Thomas Hunziker, Guenter Laufer
  • Adduct of topiramate and tramadol hydrochloride and uses thereof
    Publication number: 20060234949
    Abstract: This invention relates to a new pharmaceutically useful compound which is a stoichiometrically 1:1 adduct of tramadol hydrochloride and topiramate, and to the manufacture and use thereof.
    Type: Application
    Filed: May 16, 2003
    Publication date: October 19, 2006
    Inventors: Rainer Naeff, Sonja Spycher-Huber, Thomas Hunziker, Guenter Laufer
  • Erythropoietin liposomal dispersion
    Publication number: 20040052838
    Abstract: The present invention relates to a liposome based formulation of erythropoietin comprising:
    Type: Application
    Filed: September 10, 2003
    Publication date: March 18, 2004
    Inventors: Rainer Naeff, Sandro Delmenico, Andre Wetter, Frank-Ulrich Floether
  • Erythropoietin liposomal dispersion
    Patent number: 6645522
    Abstract: The present invention relates to a liposome based formulation of erythropoietin comprising: (a) an effective amount of an erythropoietin; (b) a lipidic phase comprising: (i) lecithin or hydrogenated lecithin; (ii) optionally, a charged electropositive or electronegative lipid compound; and (iii) cholesterol or a derivative thereof selected from cholesterol esters, polyethylene glycol derivatives of cholesterol (PEG-cholesterols), and organic acid derivatives of cholesterols; and (c) a phosphate buffer. The liposome based parenteral dosage form of the invention is prepared by means of an ethanol injection technique. The composition avoids the need for use of human serum albumin and exhibits superior stability.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: November 11, 2003
    Assignee: Cilag AG
    Inventors: Rainer Naeff, Sandro Delmenico, André Wetter, Frank-Ulrich Floether
  • Wound dressing for the controlled release of active substance to wounds, and process for its manufacture
    Patent number: 6399091
    Abstract: A wound dressing for the controlled release of active substance to wounds, especially of wound healing-promoting substances to slow-healing, chronic wounds, is characterized in that said wound dressing has a layered structure for the purpose of absorbing liquid, especially wound exudate, under volume increase, said layered structure at least comprising one polymer-containing layer (1), one woven fabric-like or nonwoven-like layer (2) and at least one active substance, and in that the polymer-containing layer (1) contains hydrocolloid-containing swellable hydrogel as absorbent for liquid.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: June 4, 2002
    Assignee: LTS Lohamann Therapie-Systeme AG
    Inventors: Achim Berthold, Walter Muller, Frank-Ulrich Flother, Rainer Naeff
  • ERYTHROPO IETIN LIPOSOMAL DISPERSION
    Publication number: 20020028236
    Abstract: The present invention relates to a liposome based formulation of erythropoietin comprising:
    Type: Application
    Filed: February 18, 1999
    Publication date: March 7, 2002
    Inventors: RAINER NAEFF, SANDRO DELMENICO, ANDRE WETTER, FRANK-ULRICH FLOETHER
  • Cyclodextrin cladribine formulations
    Patent number: 6194395
    Abstract: There is provided by the present invention liquid injectable and oral solid pharmaceutical dosage forms containing a mixture of cladribine (2-chloro-2′-deoxyadenosine; 2-CdA) and cyclodextrin.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: February 27, 2001
    Assignee: Orthro-McNeil Pharmaceutical, Inc.
    Inventors: Thomas W. Schultz, Rainer Naeff
  • Liposome-based topical vitamin D formulation
    Patent number: 5834016
    Abstract: A liposome-based formulation with good skin penetration of the effective substance, particularly calcitriol, is described. This formulation is well suited for the treatment of psoriasis.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: November 10, 1998
    Assignee: Cilag AG
    Inventors: Rainer Naeff, Sandro Delmenico, Rene Spycher, Mike Corbo, Frank Flother