Abstract: The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.

Abstract: In the method of processing signals, multi-path signals are received, channel estimates for the received multi-path signals are determined, and a combining operation is applied to the multi-path signals, the combining operation being a function of a correlation matrix of the received multi-path signals, a correlation matrix of estimates for channels of the received multi-path signals, a cross-correlation matrix of the channels and channel estimates for the received multi-path signals, and the channel estimates.

Abstract: Apparatus and process for producing a fixed bed in a metallurgical unit, preferably for producing pig iron or primary steel products from iron-containing charge materials, in particular in a melted gasifier, in which a lumpy bulk material, which contains ore-containing and carbon-containing constituents, prereduced iron ore, preferably sponge iron, and preferably lumpy, coal, is charged onto a surface. Through mixing of the ore-containing constituent with the carbon-containing constituent of the bulk material takes place. The entire ore-containing constituent is charged onto an active circumferential or peripheral region of the fixed bed, at which the thorough, preferably uniform mixing of the ore-containing constituent with the carbon-containing constituent of the bulk material takes place preferably outward of the center. A device scatters the stream of bulk material aver the surface and less of the material is scattered at the center, so that heavier grain lumps segregate themselves toward the center.

Abstract: Compounds of general formula (I) which are selective beta-3-agonists and useful for the treatment of obesity and type II diabetes. Exemplary compounds are: [4-(1-{3-[2-(3-phenylsulphonylamino-phenyl)-2-hydroxy-ethylamino]-3-methyl-butyl}-1H-imidazol-4-yl)-phenyl]-acetic acid and methyl [4-(1-{3-[2-(3-phenylsulphonylamino-phenyl)-2-hydroxy-ethylamino]-3-methyl-butyl}-1H-imidazol-4-yl)-phenyl]-acetate.

Abstract: Compounds of the formula which are selective beta-3-agonists and useful for the treatment of obesity and type II diabetes. Exemplary compounds are: ethyl 3-{3-[(R)-2-(3-benzenesulphonylamino-phenyl)-2-hydroxy-ethylamino]-3-methyl-butyl}-3H-imidazo[4,5-b]pyridine-5-carboxylate and 3-{3-[(R)-2-(3-benzenesulphonylamino-phenyl)-2-hydroxy-ethylamino]-3-methyl-butyl}-3H-imidazo[4,5-b]pyridine-5-carboxylic acid.

Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R4 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.

Abstract: A method for loading a pourable material in a container, the material being supplied by gravity forces through a channel which is arranged in the opening of the container. In order to obtain a desired material distribution in the container, the material, a little bit before the passage thereof through the opening, i.e. inside the channel, is exposed to forces modifying the displacement direction of the material given by the channel and the gravity forces.

Abstract: The present invention provides a method for coordinating control of radio resources for multicast/broadcast services in distributed radio resource management. One exemplary embodiment of the method may include communicating information between a plurality of units having radio resource management responsibilities. The communicated information is related to coordinating at least one multicast/broadcast service provided by the plurality of units.

Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R4 have the meanings given in ths claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.

Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.

Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases.

Abstract: A method for loading a pourable material in a container, the material being supplied by gravity forces through a channel which is arranged in the opening of the container. In order to obtain a desired material distribution in the container, the material, a little bit before the passage thereof through the opening, i.e. inside the channel, is exposed to forces modifying the displacement direction of the material given by the channel and the gravity forces.

Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases.

Abstract: A method for controlling the opening of at least one intake valve of a combustion chamber in a periodically working piston engine, at least one intake valve of the combustion chamber being opened during a first partial period of a working period of the piston engine for charging the combustion chamber; and at least one intake valve of the combustion chamber being opened during a second partial period of the working period, wherein the second partial period begins after the combustion of the combustion chamber charge and has no overlap with the first partial period.

Abstract: Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

Abstract: Disclosed is a simple, easy-to-produce, and reliable connection between a shaft of a gas exchange valve and an actuator. This connection is detachable and, as a result, can be connected and disconnected multiple times. It is also possible to dispose the coupling piece on the shaft of the gas exchange valve and provide circumferential grooves on the control element of the actuator.

Abstract: A method and a device for operating an internal combustion engine having a plurality of cylinders are described, each cylinder having at least one intake valve and one exhaust valve having fully variable valve control, a fuel feed to at least one first cylinder of the plurality of cylinders being deactivated, a first quantity of fresh air being drawn in by opening the at least one intake valve of the at least one first cylinder in a first downward movement of the piston of the at least one first cylinder, and a second quantity of fresh air being ejected by opening the at least one exhaust valve with a first upward movement of the piston of the at least one first cylinder.

Abstract: The present invention relates to cyanothiophenes of general formula wherein the Rs are defined as in the claims, the tautomers, their stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly a glugacon receptor-antagonistic activity.

Abstract: Disclosed is a simple, easy-to-produce, and reliable connection between a shaft of a gas exchange valve and an actuator. This connection is detachable and, as a result, can be connected and disconnected multiple times. It is also possible to dispose the coupling piece on the shaft of the gas exchange valve and provide circumferential grooves on the control element of the actuator 5.

Abstract: The present invention relates to a connection between a shaft end of a gas exchange valve of an internal combustion engine and a sleeve-shaped actuating element of a valve actuator, which is guided in an axially movable manner within a pressure region, which is able to be pressurized with a pressure medium, of the valve actuator and at least partially surrounds the shaft end. The present invention provides for the connection to be situated outside of the pressure region and in the region of an opening, which is formed on the side of the valve actuator away from the combustion chamber, and is, for example, coaxial to the shaft end.