Patents by Inventor Raja R. Mamidi

Raja R. Mamidi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to remove citrate and aluminum from proteins
    Patent number: 6693173
    Abstract: A method is provided for removing citrate, aluminum, and other multivalent ions and contaminants from proteins by adjusting the pH of a solution containing the protein to a pH from about 7 to about 10, and diafiltering the pH-adjusted solution against aqueous solutions which have a low level of ions.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: February 17, 2004
    Assignee: Alpha Therapeutic Corporation
    Inventors: Raja R. Mamidi, Leticia R. Regis, Mauro C. Mojica, Hirokazu Ito, Takashi Goto
  • Method for preparing dual virally inactivated immune globulin for intravenous administration
    Patent number: 6504012
    Abstract: A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the purified gamma globulin, in any order, with a solvent-detergent for viral inactivation and a heat treating for viral inactivation. Thereafter, denatured impurities, residual solvent and aggregate generated by the heat treatment are removed from the gamma globulin.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: January 7, 2003
    Assignee: Alpha Therapeutic Corporation
    Inventors: Raja R. Mamidi, Andranik Bagdasarian, Gorgonio Canaveral, Kazuo Takechi
  • Method to remove citrate and aluminum from proteins
    Publication number: 20020132986
    Abstract: A method is provided for removing citrate, aluminum, and other multivalent ions and contaminants from proteins by adjusting the pH of a solution containing the protein to a pH from about 7 to about 10, and diafiltering the pH-adjusted solution against aqueous solutions which have a low level of ions.
    Type: Application
    Filed: December 26, 2000
    Publication date: September 19, 2002
    Inventors: Raja R. Mamidi, Leticia R. Regis, Mauro C. Mojica, Hirokazu Ito, Takashi Goto
  • Method to remove citrate and aluminum from proteins
    Publication number: 20020132985
    Abstract: A method is provided for removing citrate, aluminum, and other multivalent ions and contaminants from proteins by adjusting the pH of a solution containing the protein to a pH from about 7 to about 10, and diafiltering the pH-adjusted solution against aqueous solutions which have a low level of ions.
    Type: Application
    Filed: March 13, 2001
    Publication date: September 19, 2002
    Inventors: Raja R. Mamidi, Leticia R. Regis, Mauro C. Mojica, Hirokazu Ito, Takashi Goto
  • Method for repairing dual virally inactivated immune globulin for intravenous administration
    Patent number: 6441144
    Abstract: A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the purified gamma globulin, with a solvent-detergent for viral inactivation and a heat treating for viral inactivation. Thereafter, denatured impurities, residual solvent and aggregate generated by the heat treatment are removed from the gamma globulin.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: August 27, 2002
    Assignee: Alpha Therapeutic Corporation
    Inventors: Raja R. Mamidi, Andranik Bagdasarian, Gorgonio Canaveral, Kazuo Takechi
  • Method for preparing dual virally inactivated immune globulin for intravenous administration
    Publication number: 20010044524
    Abstract: A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the purified gamma globulin, in any order, with a solvent-detergent for viral inactivation and a heat treating for viral inactivation. Thereafter, denatured impurities, residual solvent and aggregate generated by the heat treatment are removed from the gamma globulin.
    Type: Application
    Filed: May 22, 2001
    Publication date: November 22, 2001
    Applicant: ALPHA THERAPEUTIC CORPORATION
    Inventors: Raja R. Mamidi, Andranik Bagdasarian, Gorgonio Canaveral, Kazuo Takechi
  • Manufacturing method for intraveneously administrable immune globulin and resultant product
    Patent number: 6162904
    Abstract: A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by heat treating for viral inactivation and fractionating an impure gamma globulin solution and then treating the purified gamma globulin with a solvent-detergent for further viral inactivation. In a continuous process disclosed herein, partially purified gamma globulin solids is not recovered as an intermediate product during the disclosed process. In the continuous process, the fractionation to obtain a purified gamma globulin solution is carried out without precipitation of the desired gamma globulin.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: December 19, 2000
    Assignee: Alpha Therapeutic Corporation
    Inventors: Raja R. Mamidi, Andranik Bagdasarian, Gorgonio Canaveral, Kazuo Takechi
  • IgA preparation and process of making the same
    Patent number: 5258177
    Abstract: A method of preparing an IgA rich preparation comprising exposing a plasma fraction to an amino acid, organic salt or inorganic salt with optional chromatographic treatment yielding a product suitable for use in medical conditions treatable with IgA.
    Type: Grant
    Filed: December 10, 1991
    Date of Patent: November 2, 1993
    Assignee: Alpha Therapeutic Corporation
    Inventors: Yahiro Uemura, Sunnie Park, Raja R. Mamidi, Charles M. Heldebrandt