Abstract: An implantable system for managing urinary incontinence includes a sling with an elongate body member having a proximal portion, a distal portion and an intermediate portion. The intermediate portion is configured to be positioned underneath urethra of a subject for providing an adequate support to prevent leakage of urine during a stress event. A pressure sensor communicatively coupled with the elongated body member is configured to be positioned in an abdominal cavity and adapted to sense an increase in intra-abdominal pressure. The pressure sensor generates a first signal that is indicative of a change in the intra-abdominal pressure upon occurrence of the stress event. A processing circuit processes the first signal sensed by the pressure sensor and generates a second signal causing an adjustment of tensioning force in the elongate body member thereby changing magnitude of a supporting force to the urethra.

Abstract: The technology described herein relates to methods and compositions to prevent or treat vascular disease by targeting the epigenetic regulation of gene expression of vascular smooth muscle cell cytoskeletal proteins.

Abstract: An ecosystem is configured to facilitate digital exchange of digital assets in a digital asset marketplace. The ecosystem includes one or more of a plurality of participant systems selected from a list of participant systems including asset user systems, asset holder systems, and asset mining systems. The ecosystem operates on a computer-executable asset wrapper that is associated with the digital asset and that is configured in the form of a multi-layered structure. The ecosystem also includes a codec that is associated with the asset wrapper and configured as a computer executable file. The codec is executed responsive to a request for an exchange on the marketplace that is associated with the digital asset. The ecosystem further includes a blockchain device to execute a blockchain smart contract for the asset exchange. The blockchain smart contract is executed against a set of right tokens characterizing a specific cryptocurrency value.

Abstract: The invention provides an implantable system for managing urinary incontinence. The system includes a sling with an elongate body member having a proximal portion, a distal portion and an intermediate portion. The intermediate portion is configured to be positioned underneath urethra of a subject for providing an adequate support to prevent leakage of urine during a stress event. The system may include a pressure sensor communicatively coupled with the elongated body member and configured to be positioned in an abdominal cavity and adapted to sense an increase in intra-abdominal pressure. The pressure sensor generates a first signal that is indicative of a change in the intra-abdominal pressure upon occurrence of the stress event. The system includes a processing circuit to process the first signal sensed by the pressure sensor.

Abstract: In an example, an ecosystem is disclosed that may facilitate digital exchange of a digital asset stored as a computer executable file. The ecosystem may include a plurality of participant systems, wherein the plurality of participant systems may include at least one of an asset user system, an asset holder system, and an asset mining system. The ecosystem may include an asset wrapper associated with the digital asset and configured in the form of a multi-layered structure and computer-executable document. The ecosystem may include a codec configured as a computer executable file and associated with the asset wrapper, wherein the codec may be executed when an external request for the asset exchange is initiated. The ecosystem may include a blockchain device to execute a blockchain smart contract for the asset exchange, wherein the smart contract is executed against a pre-defined number of right tokens characterizing a specific cryptocurrency-value.

Abstract: The present invention provides an implant that includes inflatable anchors that are configured to assume an inflated state and a relaxed state. The implant includes a tubular member mechanically coupled to one or more anchors of the inflatable anchors. The tubular member includes a lumen that provides a passageway for circulating a fluid through the one or more of the plurality of inflatable anchors and allow them to protrude and pierce through bodily tissues. In an embodiment, the implant may include a plurality of bi-directional barbs instead of the inflatable anchors. The plurality of barbs may be activated by a flexible member such that the activation is configured to cause anchoring of the barbs into soft tissues during a surgical procedure. The present invention provides a method for placing an implant.

Abstract: The technology described herein relates to methods and compositions to prevent or treat vascular disease by targeting the epigenetic regulation of gene expression of vascular smooth muscle cell cytoskeletal proteins.

Abstract: The invention provides an implantable system for managing urinary incontinence. The system includes a sling with an elongate body member having a proximal portion, a distal portion and an intermediate portion. The intermediate portion is configured to be positioned underneath urethra of a subject for providing an adequate support to prevent leakage of urine during a stress event. The system may include a pressure sensor communicatively coupled with the elongated body member and configured to be positioned in an abdominal cavity and adapted to sense an increase in intra-abdominal pressure. The pressure sensor generates a first signal that is indicative of a change in the intra-abdominal pressure upon occurrence of the stress event. The system includes a processing circuit to process the first signal sensed by the pressure sensor.

Abstract: In an example, an ecosystem is disclosed that may facilitate digital exchange of a digital asset stored as a computer executable file. The ecosystem may include a plurality of participant systems, wherein the plurality of participant systems may include at least one of an asset user system, an asset holder system, and an asset mining system. The ecosystem may include an asset wrapper associated with the digital asset and configured in the form of a multi-layered structure and computer-executable document. The ecosystem may include a codec configured as a computer executable file and associated with the asset wrapper, wherein the codec may be executed when an external request for the asset exchange is initiated. The ecosystem may include a blockchain device to execute a blockchain smart contract for the asset exchange, wherein the smart contract is executed against a pre-defined number of right tokens characterizing a specific cryptocurrency-value.

Abstract: The present invention discloses a biomechanically compatible implant, wherein arbitrary selectable discrete locations of the the implant are defined to exhibit biomechanical characteristics in accordance with biomechanical characteristics at arbitrary selectable discrete locations of a bodily tissue where the respective arbitrary selectable discrete locations of the implant are configured to be attached. The implant may be configured to repair prolapse in an embodiment. In another embodiment, the implant may be configured to repair urinary incontinence. The present invention further discloses a device for generating a biomechanical characteristics pattern of the bodily tissue and the implant. The present invention further discloses a system for designing and fabricating the biomechanically compatible implant.

Abstract: The invention provides an implantable system for managing urinary incontinence. The system includes a sling with an elongate body member having a proximal portion, a distal portion and an intermediate portion. The intermediate portion is configured to be positioned underneath urethra of a subject for providing an adequate support to prevent leakage of urine during a stress event. The system may include a pressure sensor communicatively coupled with the elongated body member and configured to be positioned in an abdominal cavity and adapted to sense an increase in intra-abdominal pressure. The pressure sensor generates a first signal that is indicative of a change in the intra-abdominal pressure upon occurrence of the pressure event. The system includes a processing circuit to process the signal sensed by the pressure sensor.

Abstract: The present invention discloses a biomechanically compatible implant, wherein arbitrary selectable discrete locations of the implant are defined to exhibit biomechanical characteristics in accordance with biomechanical characteristics at arbitrary selectable discrete locations of a bodily tissue where the respective arbitrary selectable discrete locations of the implant are configured to be attached. The implant may be configured to repair prolapse in an embodiment. In another embodiment, the implant may be configured to repair urinary incontinence. The present invention further discloses a device for generating a biomechanical characteristics pattern of the bodily tissue and the implant. The present invention further discloses a system for designing and fabricating the biomechanically compatible implant.

Abstract: The present invention provides an implant that includes inflatable anchors that are configured to assume an inflated state and a relaxed state. The implant includes a tubular member mechanically coupled to one or more anchors of the inflatable anchors. The tubular member includes a lumen that provides a passageway for circulating a fluid through the one or more of the plurality of inflatable anchors and allow them to protrude and pierce through bodily tissues. In an embodiment, the implant may include a plurality of bi-directional barbs instead of the inflatable anchors. The plurality of barbs may be activated by a flexible member such that the activation is configured to cause anchoring of the barbs into soft tissues during a surgical procedure. The present invention provides a method for placing an implant.

Abstract: The invention provides an implantable system for managing urinary incontinence. The system includes a sling with an elongate body member having a proximal portion, a distal portion and an intermediate portion. The intermediate portion is configured to be positioned underneath urethra of a subject for providing an adequate support to prevent leakage of urine during a stress event. The system may include a pressure sensor communicatively coupled with the elongated body member and configured to be positioned in an abdominal cavity and adapted to sense an increase in intra-abdominal pressure. The pressure sensor generates a first signal that is indicative of a change in the intra-abdominal pressure upon occurrence of the pressure event. The system includes a processing circuit to process the signal sensed by the pressure sensor.

Abstract: The present invention provides an implant that includes inflatable anchors that are configured to assume an inflated state and a relaxed state. The implant includes a tubular member mechanically coupled to one or more anchors of the inflatable anchors. The tubular member includes a lumen that provides a passageway for circulating a fluid through the one or more of the plurality of inflatable anchors and allow them to protrude and pierce through bodily tissues. In an embodiment, the implant may include a plurality of bi-directional barbs instead of the inflatable anchors. The plurality of barbs may be activated by a flexible member such that the activation is configured to cause anchoring of the barbs into soft tissues during a surgical procedure. The present invention provides a method for placing an implant.

Abstract: The present invention discloses a biomechanically compatible implant, wherein arbitrary selectable discrete locations of the implant are defined to exhibit biomechanical characteristics in accordance with biomechanical characteristics at arbitrary selectable discrete locations of a bodily tissue where the respective arbitrary selectable discrete locations of the implant are configured to be attached. The implant may be configured to repair prolapse in an embodiment. In another embodiment, the implant may be configured to repair urinary incontinence. The present invention further discloses a device for generating a biomechanical characteristics pattern of the bodily tissue and the implant. The present invention further discloses a system for designing and fabricating the biomechanically compatible implant.

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to reduce circulating levels of ApoB-100 or LDL. These compounds may also be used to treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

Abstract: A method for managing power consumption in a stackable switch system, the method comprises determining a power management strategy for a plurality of switches in a stackable switch system. The method also comprises determining, by a processor associated with a first switch of the stackable switch system, that at least one criterion for causing the second switch to enter a power save mode has been met, based on the determined power management strategy. The method further comprises providing a first command for causing a second switch of the stackable switch system to enter the power save mode. The method also comprises determining that at least one criterion for causing the second switch to exit the power save mode has been met, based on the determined power management strategy. The method further comprises providing a second command for causing the second switch to wake from the power save mode.

Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to reduce circulating levels of ApoB-100 or LDL. These compounds may also be used to treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

Abstract: Private information is removed from dictation so that the transcriptionist never has access to the private information. A software program is used to first extract the private information and then later (after the transcription is completed by, for example, the transcriptionist) reinsert the removed private information back into the final report. This eliminates any possibility of a human in the transcription process accessing the private information.