Patents by Inventor Rajesh Bhikhu Parekh
Rajesh Bhikhu Parekh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040110938Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Schizophrenia, for monitoring the effectiveness of Schizophrenia treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Schizophrenia-Associated Features (SFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Schizophrenia-Associated Protein Isoforms (SPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated SPIs, antibodies immunospecific for SPIs, and kits comprising the aforesaid.Type: ApplicationFiled: February 23, 2001Publication date: June 10, 2004Inventors: Rajesh Bhikhu Parekh, Herath Mudiyanselage Athula Chandrasiri Herath, Christian Rohlff, Jonathan Alexander Terrett, Kerry Louise Tyson
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Publication number: 20040022794Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.Type: ApplicationFiled: October 3, 2002Publication date: February 5, 2004Inventors: L. Kathryn Durham, David L. Friedman, Herath Mudiyanselage Athula Chandrasiri Herath, Lida H. Kimmel, Rajesh Bhikhu Parekh, David M. Potter, Christian Rohlff, B. Michael Silber, Peter Jeffrey Snyder, Holly Daria Soares, Thomas R. Stiger, P. Trey Sunderland, Robert Reid Townsend, W. Frost White, Stephen A. Williams
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Publication number: 20030190615Abstract: The present invention provides a protein (DPI-6) identified in CSF, compositions comprising the protein, including vaccines and antibodies which are immunospecific for the protein. The use of the protein in the diagnosis, screening, treatment and prophylaxis of a neurological or neuropsychiatric condition is also provided.Type: ApplicationFiled: June 10, 2002Publication date: October 9, 2003Inventors: Herath Mudiyanselage Athula Chandrasiri Herath, Rajesh Bhikhu Parekh, Christian Rohlff, Thakorhlai Parshotambhai Patel
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Publication number: 20030092614Abstract: The present invention provides a protein (ADPI-41) identified in brain tissue, compositions comprising the protein, including vaccines and antibodies, which are immunospecific for the protein. The use of the protein in the diagnosis, screening, treatment and prophylaxis of Alzheimer's disease is also provided.Type: ApplicationFiled: December 10, 2001Publication date: May 15, 2003Inventors: Herath Mudiyanselage Athula Chandrasiri Herath, Rajesh Bhikhu Parekh, Christian Rohlff, Jonathan Alexander Terrett, Kerry Louise Tyson
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Publication number: 20030083823Abstract: The present invention is directed to efficient, computer-assisted methods and apparatus for identifying, selecting and characterizing biomolecules in a biological sample. According to the invention, a biological sample is first treated to isolate biomolecules of interest, and a two-dimensional array is then generated by separating the biomolecules present in a complex mixture. The invention provides a computer-generated digital profile representing the identity and relative abundance of a plurality of biomolecules detected in the two-dimensional array, thereby permitting computer-mediated comparison of profiles from multiple biological samples. This automatable technology for screening biological samples and comparing their profiles permits rapid and efficient identification of individual biomolecules whose presence, absence or altered expression is associated with a disease or condition of interest.Type: ApplicationFiled: September 30, 2002Publication date: May 1, 2003Inventors: Rajesh Bhikhu Parekh, James Alexander Bruce, Robin Philp, Lida H. Kimmel, David L. Friedman
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Publication number: 20030077603Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of hepatoma, for monitoring the effectiveness of hepatoma treatment, and for drug development. Hepatoma-Diagnostic Features (HFs), detectable by two-dimensional electrophoresis of serum or plasma are described. The invention further provides Hepatoma-Diagnostic Protein Isoforms (HPIs) detectable in serum or plasma, preparations comprising isolated HPIs, antibodies immunospecific for HPIs, and kits comprising the aforesaid.Type: ApplicationFiled: February 19, 2002Publication date: April 24, 2003Inventors: Rajesh Bhikhu Parekh, Thakorbhai Parshotambhai Patel, Robert Reid Townsend, Christopher Moyses, Philip J. Johnson
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Publication number: 20030064419Abstract: The present invention relates to the identification of proteins and protein isoforms that are associated with breast cancer and its onset and development, and of genes encoding the same, and to their use for e.g., clinical screening, diagnosis, prognosis, therapy and prophylaxis, as well as for drug screening and development of pharmaceutical products.Type: ApplicationFiled: November 20, 2001Publication date: April 3, 2003Inventors: Herath Mudiyanselage Athula Chandrasiri Herath, Michael John O'Hare, Martin John Page, Rajesh Bhikhu Parekh, Michael Derek Waterfield
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Publication number: 20030064411Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment and for drug development. Alzheimer's disease-Associated Features (ADFs) detectable by two-dimensional electrophoresis of brain tissue are described. The invention further provides Alzheimer's disease-Associated Protein Isoforms (ADPIs) detectable in brain tissue, preparations comprising isolated ADPIs, antibodies specific for ADPIs and kits comprising the aforesaid.Type: ApplicationFiled: December 10, 2001Publication date: April 3, 2003Inventors: Herath Mudiyanselage Athula Chandrasiri Herath, Rajesh Bhikhu Parekh, Christian Rohlff
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Patent number: 6534321Abstract: A method for analyzing a sample containing a plurality of analytes, comprises labelling the analytes with a detectable label, the label being chosen such that its detectability can be influenced by modifying the conditions of detection; separating the labelled analytes, before or after labeling,; and determining the presence of the separated analytes under the modified conditions and also, if desired, the unmodified conditions. Suitable detection apparatus comprises a support for a gel, means for detecting one or more analytes in the gel, and means for reducing the temperature of the gel to below ambient temperature, e.g., to no more than 0°C.Type: GrantFiled: January 8, 1999Date of Patent: March 18, 2003Assignee: Oxford GlycoSciences (UK) Ltd.Inventors: Rajesh Bhikhu Parekh, Paul Nicholas Goulding, Dale Robert Pfost
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Publication number: 20030032773Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of BAD, for monitoring the effectiveness of BAD treatment, and for drug development. BAD-Associated Features (DFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides BAD-Associated Protein Isoforms (DPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated DPIs, antibodies immunospecific for DPIs, and kits comprising the aforesaid.Type: ApplicationFiled: February 23, 2001Publication date: February 13, 2003Inventors: Herath Mudiyanselage Athula Chandrasiri Herath, Rajesh Bhikhu Parekh, Christian Rohlff, Jonathan Alexander Terrett, Kerry Louise Tyson
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Publication number: 20030032200Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of BAD, for monitoring the effectiveness of BAD treatment, and for drug development. BAD-Associated Features (DFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides BAD-Associated Protein Isoforms (DPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated DPIs, antibodies immunospecific for DPIs, and kits comprising the aforesaid.Type: ApplicationFiled: February 23, 2001Publication date: February 13, 2003Inventors: Herath Mudiyanselage Athula Chandrasiri Herath, Rajesh Bhikhu Parekh, Christian Rohlff
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Publication number: 20020191825Abstract: The present invention provides computer-assisted methods and apparatus for identifying, selecting and characterizing biomolecules in a biological sample. A two-dimensional array is generated by separating biomolecules present in a complex mixture. A computer-readable profile is constructed representing the identity and relative abundance of a plurality of biomolecules detected by imaging the two dimensional array. Computer-mediated comparison of profiles from multiple samples permits automated identification of subsets of biomolecules that satisfy pre-ordained criteria. Identified biomolecules can be automatically isolated from the two dimensional array by a robotic device in accordance with computer-generated instructions.Type: ApplicationFiled: August 22, 2002Publication date: December 19, 2002Inventors: Rajesh Bhikhu Parekh, Robert Amess, James Alexander Bruce, Sally Barbara Prime, Albert Edward Platt, Richard Michael Stoney
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Patent number: 6480618Abstract: The present invention provides computer-assisted methods and apparatus for identifying, selecting and characterizing biomolecules in a biological sample. A two-dimensional array is generated by separating biomolecules present in a complex mixture. A computer-readable profile is constructed representing the identity and relative abundance of a plurality of biomolecules detected by imaging the two dimensional array. Computer-mediated comparison of profiles from multiple samples permits automated identification of subsets of biomolecules that satisfy pre-ordained criteria. Identified biomolecules can be automatically isolated from the two dimensional array by a robotic device in accordance with computer-generated instructions.Type: GrantFiled: November 28, 2000Date of Patent: November 12, 2002Assignee: Oxford Glycosciences (UK) Ltd.Inventors: Rajesh Bhikhu Parekh, Robert Amess, James Alexander Bruce, Sally Barbara Prime, Albert Edward Platt, Richard Michael Stoney
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Publication number: 20020164668Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.Type: ApplicationFiled: April 3, 2001Publication date: November 7, 2002Inventors: L. Kathryn Durham, David L. Friedman, Herath Mudiyanselage Athula Chandrasiri Herath, Lida H. Kimmel, Rajesh Bhikhu Parekh, David M. Potter, Christian Rohlff, B. Michael Silber, Thomas R. Stiger, P. Trey Sunderland, Robert Reid Townsend, W. Frost White, Stephen A. Williams
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Publication number: 20020142303Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Schizophrenia, for monitoring the effectiveness of Schizophrenia treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Schizophrenia-Associated Features (SFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Schizophrenia-Associated Protein Isoforms (SPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated SPIs, antibodies immunospecific for SPIs, and kits comprising the aforesaid.Type: ApplicationFiled: February 23, 2001Publication date: October 3, 2002Inventors: Rajesh Bhikhu Parekh, Herath Mudiyanselage Athula Chandrasiri Herath, Christn Rohlff
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Patent number: 6459994Abstract: The present invention is directed to efficient, computer-assisted methods and apparatus for identifying, selecting and characterizing biomolecules in a biological sample. According to the invention, a biological sample is first treated to isolate biomolecules of interest, and a two-dimensional array is then generated by separating the biomolecules present in a complex mixture. The invention provides a computer-generated digital profile representing the identity and relative abundance of a plurality of biomolecules detected in the two-dimensional array, thereby permitting computer-mediated comparison of profiles from multiple biological samples. This automatable technology for screening biological samples and comparing their profiles permits rapid and efficient identification of individual biomolecules whose presence, absence or altered expression is associated with a disease or condition of interest.Type: GrantFiled: November 28, 2000Date of Patent: October 1, 2002Assignee: Oxford GlycoSciences (UK) LtdInventors: Rajesh Bhikhu Parekh, James Alexander Bruce, Robin Philp, Lida H. Kimmel, David L. Friedman
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Patent number: 6278794Abstract: The present invention provides computer-assisted methods and apparatus for identifying, selecting and characterizing biomolecules in a biological sample. A two-dimensional array is generated by separating biomolecules present in a complex mixture. A computer-readable profile is constructed representing the identity and relative abundance of a plurality of biomolecules detected by imaging the two dimensional array. Computer-mediated comparison of profiles from multiple samples permits automated identification of subsets of biomolecules that satisfy pre-ordained criteria. Identified biomolecules can be automatically isolated from the two dimensional array by a robotic device in accordance with computer-generated instructions.Type: GrantFiled: February 8, 2000Date of Patent: August 21, 2001Assignee: Oxford Glycosciences (UK) LtdInventors: Rajesh Bhikhu Parekh, Robert Amess, James Alexander Bruce, Sally Barbara Prime, Albert Edward Platt, Richard Michael Stoney
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Patent number: 6180779Abstract: O-glycan is released from a glycoconjugate with a substantially anhydrous hydrazine reagent, the glycoconjugate being substantially salt-free and substantially anhydrous. Released O-glycan is recovered in substantially unreduced and intact form using a chromatographic material.Type: GrantFiled: March 12, 1993Date of Patent: January 30, 2001Assignee: Oxford GlycoSystems LimitedInventors: Rajesh Bhikhu Parekh, Anthony Hugh Merry, James Bruce
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Patent number: 6064754Abstract: The present invention provides computer-assisted methods and apparatus for identifying, selecting and characterizing biomolecules in a biological sample. A two-dimensional array is generated by separating biomolecules present in a complex mixture. A computer-readable profile is constructed representing the identity and relative abundance of a plurality of biomolecules detected by imaging the two dimensional array. Computer-mediated comparison of profiles from multiple samples permits automated identification of subsets of biomolecules that satisfy pre-ordained criteria. Identified biomolecules can be automatically isolated from the two dimensional array by a robotic device in accordance with computer-generated instructions.Type: GrantFiled: December 1, 1997Date of Patent: May 16, 2000Assignee: Oxford Glycosciences (UK) Ltd.Inventors: Rajesh Bhikhu Parekh, Robert Amess, James Alexander Bruce, Sally Barbara Prime, Albert Edward Platt, Richard Michael Stoney
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Patent number: 5747347Abstract: A method for distinguishing between carbohydrates or glycoconjugates in a mixture thereof, wherein the or each carbohydrate or glycoconjugate is a hydrophilic fluorescently-labelled saccharide molecule, wherein the label is a --NR--Ph--CO-- group, wherein R is selected from H and substituents, and Ph is phenylene.Type: GrantFiled: March 19, 1996Date of Patent: May 5, 1998Assignee: Oxford Glycosystems Ltd.Inventors: David Harry Hawke, Rajesh Bhikhu Parekh, Paul Goulding, Stephen Alexander Charles