Patents by Inventor Rajesh Kumar Thaper

Rajesh Kumar Thaper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF MALIC ACID SALT OF SUNITINIB
    Publication number: 20160185760
    Abstract: The present invention relates to a process of preparation of malic acid salt of sunitinib.(I).
    Type: Application
    Filed: February 25, 2011
    Publication date: June 30, 2016
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Sudhir Singh SANWAL, Saridi Madhava Dileep KUMAR, Swargam SATHYANARAYANA, Rajesh Kumar THAPER, Mohan PRASAD
  • Process for the preparation of dasatinib and its intermediates
    Patent number: 9365526
    Abstract: The present invention relates to processes for the preparation of dasatinib and its intermediates.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: June 14, 2016
    Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITED
    Inventors: Jagdev Singh Jaryal, Munish Kapoor, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF DASATINIB AND ITS INTERMEDIATES
    Publication number: 20150336913
    Abstract: The present invention relates to processes for the preparation of dasatinib and its intermediates.
    Type: Application
    Filed: December 31, 2013
    Publication date: November 26, 2015
    Inventors: Jagdev Singh JARYAL, Munish KAPOOR, Swargam SATHYANARAYANA, Rajesh Kumar THAPER, Mohan PRASAD
  • Process for the preparation of crystalline form I of methanesulfonate salt of dabigatran etexilate
    Patent number: 9150542
    Abstract: The present invention relates to a process for the preparation of crystalline Form I of methanesulfonate salt of dabigatran etexilate. (Formula (I)). The present invention does not require the isolation of the dabigatran etexilate intermediate.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: October 6, 2015
    Assignee: RANBAXY LABORATORIES LIMITED
    Inventors: Sudhir Singh Sanwal, Anandam Vempali, Balaguru Murugesan, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20150246899
    Abstract: The present invention relates to a process for the preparation of dabigatran etexilate. The present invention also relates to trifluoroacetate salt of dabigatran etexilate and a process for its preparation. The present invention further relates to crystalline Form I and crystalline Form II of trifluoroacetate salt of dabigatran etexilate and processes for their preparation. The present invention further relates to a process for the preparation of pharmaceutically acceptable salts, including methanesulfonate salt, of dabigatran etexilate.
    Type: Application
    Filed: September 30, 2013
    Publication date: September 3, 2015
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Anandam Vempali, Sudhir Singh Sanwal, Balaguru Murugesan, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20150225370
    Abstract: The present invention provides hydrobromide salt of dabigatran etexilate of formula (IV) and its process for the preparation. The present invention further provides crystalline Form I and crystalline Form II of hydrobromide salt of dabigatran etexilate and processes for their preparation. The present invention further relates to a process for the preparation of pharmaceutically ac ceptable salts, including methanesulfonate salt, of dabigatran etexilate using hydrobromide salt of dabigatran etexilate of the present invention.
    Type: Application
    Filed: September 30, 2013
    Publication date: August 13, 2015
    Inventors: Anandam Vempali, Sudhir Singh Sanwal, Balaguru Murugesan, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad
  • Salts of dexlansoprazole and their preparation
    Patent number: 9085556
    Abstract: The present invention relates to the salts of dexlansoprazole in amorphous form. The present invention further relates to processes for the preparation of salts of dexlansoprazole.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: July 21, 2015
    Assignee: RANBAXY LABORAOTORIES LIMITED
    Inventors: Anu Mittal, Anmol Kumar Ray, Mahavir Singh Khanna, Rajesh Kumar Thaper, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM I OF METHANESULFONATE SALT OF DABIGATRAN ETEXILATE
    Publication number: 20150197504
    Abstract: The present invention relates to a process for the preparation of crystalline Form I of methanesulfonate salt of dabigatran etexilate. (Formula (I)). The present invention does not require the isolation of the dabigatran etexilate intermediate.
    Type: Application
    Filed: September 2, 2013
    Publication date: July 16, 2015
    Inventors: Sudhir Singh Sanwal, Anandam Vempali, Balaguru Murugesan, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF DEXLANSOPRAZOLE
    Publication number: 20140357870
    Abstract: The present invention relates to a process for the preparation of dexlansoprazole.xH2O, wherein x is about 0.0 to about 0.1, using dexlansoprazole.xH2O, wherein x is about 2.6 to about 50.
    Type: Application
    Filed: June 20, 2012
    Publication date: December 4, 2014
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Anmol Kumar Ray, Anu Mittal, Nagaraju Gottumukkala, Mahavir Singh Khanna, Rajesh Kumar Thaper, Mohan Prasad, Sudershan Kumar Arora
  • PROCESS FOR THE PREPARATION OF ATAZANAVIR OR ITS BISULFATE SALT
    Publication number: 20140343290
    Abstract: The present invention relates to an improved process for the preparation of atazanavir bisulfate, an inhibitor of retroviral aspartate protease. The process of the present invention comprises conversion of 1,1-dimethylethyl[(2S,3R)-4-chloro-3-hydroxy-phenylbutan-2-yl]carbamate (Formula II) into 1-[4-(pyridine-2-yl)-phenyl]-4(S)-5 hydroxy-2-N-tert-butoxycarbonylamino-5(S)—N—(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane (Formula VII) without isolating intermediate compounds formed therein, followed by its subsequent conversion to atazanavir or its bisulfate salt.
    Type: Application
    Filed: July 25, 2012
    Publication date: November 20, 2014
    Inventors: Rakesh Kumar Singh, Nagaraju Gottumukkala, Mahavir Singh Khanna, Rajesh Kumar Thaper, Mohan Prasad, Sudershan Kumar Arora
  • PROCESS FOR THE PREPARATION OF AGOMELATINE
    Publication number: 20140336380
    Abstract: The present invention provides a process for the preparation of agomelatine and its intermediate compounds. The invention also provides an intermediate compound of agomelatine represented by Formula (V).
    Type: Application
    Filed: November 21, 2012
    Publication date: November 13, 2014
    Inventors: Anu Mittal, Mahavir Singh Khanna, Rajesh Kumar Thaper, Mohan Prasad, Sudershan Kumar Arora
  • Process for the preparation of dexlansoprazole
    Patent number: 8853411
    Abstract: The present invention relates to a process for the preparation of crystalline dexlansoprazole.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: October 7, 2014
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Anu Mittal, Anmol Kumar Ray, Mahavir Singh Khanna, Rajesh Kumar Thaper, Mohan Prasad
  • CRYSTALLINE FORMS OF BOSENTAN SALTS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20140187568
    Abstract: The present invention relates to crystalline forms of bosentan salts and processes for their preparation.
    Type: Application
    Filed: March 4, 2014
    Publication date: July 3, 2014
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Rakesh SINGH, Anu MITTAL, Gopal Singh BISHT, Mahavir Singh KHANNA, Rajesh Kumar THAPER, Mohan PRASAD
  • CRYSTALLINE FORMS OF BOSENTAN SALTS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20140187569
    Abstract: The present invention relates to crystalline forms of bosentan salts and processes for their preparation.
    Type: Application
    Filed: March 4, 2014
    Publication date: July 3, 2014
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Rakesh SINGH, Anu MITTAL, Gopal Singh BISHT, Mahavir Singh KHANNA, Rajesh Kumar THAPER, Mohan PRASAD
  • Crystalline forms of bosentan salts and processes for their preparation
    Patent number: 8716477
    Abstract: The present invention relates to crystalline forms of bosentan salts and processes for their preparation.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: May 6, 2014
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Rakesh Singh, Anu Mittal, Gopal Singh Bisht, Mahavir Singh Khanna, Rajesh Kumar Thaper, Mohan Prasad
  • Sorafenib dimethyl sulphoxide solvate
    Patent number: 8618305
    Abstract: The present invention provides dimethyl sulphoxide solvate of 4-(4-{3-[4-chloro-3 -(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide, process for its preparation, pharmaceutical composition comprising it and its use for the treatment of cancer. The present invention also provides a novel HPLC method for the identification, quantification and isolation of related substances of sorafenib.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: December 31, 2013
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Jagdev Singh Jaryal, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad, Sachin Deorao Zade, Ajay Shankar Singh
  • Polymorphs of sorafenib acid addition salts
    Patent number: 8614329
    Abstract: The present invention provides amorphous and crystalline forms of acid addition salts of sorafenib, pharmaceutical compositions comprising them, and their use for the treatment of cancer. The present invention also provides processes for the preparation of acid addition salts of sorafenib.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: December 24, 2013
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Jagdev Singh Jaryal, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad
  • Process for the preparation of sorafenib tosylate
    Patent number: 8609854
    Abstract: The present invention provides a process for the preparation of sorafenib tosylate, comprising contacting sorafenib free base with p-toluenesulphonic acid in water.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: December 17, 2013
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Jagdev Singh Jaryal, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad
  • Polymorphs of sorafenib acid addition salts
    Patent number: 8604208
    Abstract: The present invention provides amorphous and crystalline forms of acid addition salts of sorafenib, pharmaceutical compositions comprising them and their use for the treatment of cancer. The present invention also provides processes for the preparation of acid addition salts of sorafenib.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: December 10, 2013
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Jagdev Singh Jaryal, Swargam Sathyanarayana, Rajesh Kumar Thaper, Mohan Prasad
  • POLYMORPHS OF SORAFENIB ACID ADDITION SALTS
    Publication number: 20130274478
    Abstract: The present invention provides amorphous and crystalline forms of acid addition salts of sorafenib, pharmaceutical compositions comprising them, and their use for the treatment of cancer. The present invention also provides processes for the preparation of acid addition salts of sorafenib.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 17, 2013
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Jagdev Singh JARYAL, Swargam SATHYANARAYANA, Rajesh Kumar THAPER, Mohan PRASAD