Abstract: In one aspect, the present disclosure provides compounds which inhibit bromodomain testis (BRDT). In some embodiments, the compounds inhibit bromodomain-2 of BRDT. In another aspect, the present disclosure provides a method of inhibiting BRDT in a male subject, the method comprising administering to the male subject a therapeutically effective amount of a compound of the disclosure. In some embodiments, the method provides a contraceptive effect in the male subject.

Abstract: This disclosure describes techniques for enabling interoperability between asymmetric and symmetric Integrated Routing and Bridging (IRB) modes. An interfacing component may be configured to receive a first route advertisement from a first edge node in a Layer-2 (L2) fabric. The first route advertisement may correspond to an asymmetric format route, for instance. The interfacing component may be further configured to receive a second route advertisement from a second edge node in a L2/Layer-3 (L3) fabric. The second edge node may be configured for symmetric integrated routing and bridging (IRB). The interfacing component may be configured to re-originate the first route and the second route such that the interfacing component is included as a hop in the resultant routes between the L2 fabric and the L2/L3 fabric.

Abstract: Techniques to eliminate duplicate packets from a stream of packets. A method includes receiving a packet, hashing elements of the packet to obtain a packet partial signature, generating an action data value by appending, to the packet partial signature, unhashed packet information, accessing a hash store location in a hash store based on the action data value, determining, based on data stored at the hash store location, whether the packet is a duplicate of a previously-received packet, and based on whether the packet is a duplicate of a previously-received packet, one of allowing and preventing one of the packet and a copy of the packet to reach a downstream network node.

Abstract: The present invention relates to method of inhibition of cellular endocytosis by treating the cells with compound of formula-1 Diphenylthio urea and Diphenylurea derivatives. Said invention also discloses method of treatment of infectious diseases, neurological disease, cancer, kidney disease in a subject in need thereof by administering therapeutically effective concentration of compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives which are effective inhibitors of cellular endocytosis. Said invention also discloses compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives and pharmaceutical composition comprising compounds of Formula-1, Diphenylthio urea and Diphenylurea derivatives along with suitable excipients.

Abstract: A method and system are provided to infer and use machine learning algorithms that is applied to financial data and also to determine: (i) compliance with the applied algorithms, and (ii) whether any exceptions to and/or variations from the algorithms are within an organization's norms. A method includes: receiving financial data; applying a set of dynamic or interdependent algorithms to the received financial data to obtain a set of outcomes; and using a machine learning classifier to classify the outcomes as: (i) algorithm compliant, (ii) potentially algorithm non-compliant, or (iii) algorithm non-compliant. Additionally, the method includes generating controllership persona based actionable triggers, which on acceptance corrects the anomalies in financial data, enabling the method and system to perform as a comprehensive, contextual, consistent & machine learning powered, persona based real time controllership engine leading to reduced misstatements in reported financial data.

Abstract: This disclosure describes techniques for enabling interoperability between asymmetric and symmetric Integrated Routing and Bridging (IRB) modes. An interfacing component may be configured to receive a first route advertisement from a first edge node in a Layer-2 (L2) fabric. The first route advertisement may correspond to an asymmetric format route, for instance. The interfacing component may be further configured to receive a second route advertisement from a second edge node in a L2/Layer-3 (L3) fabric. The second edge node may be configured for symmetric integrated routing and bridging (IRB). The interfacing component may be configured to re-originate the first route and the second route such that the interfacing component is included as a hop in the resultant routes between the L2 fabric and the L2/L3 fabric.

Abstract: A method includes: generating a transition probability matrix defining a set of transition probabilities for a set of techniques, each transition probability representing a probability of transitioning from a technique i to a technique j; defining a set of emission probability vectors corresponding to the set of techniques, each emission probability vector representing a probability of detecting a technique i and a probability of preventing a technique i; defining an initial technique vector representing an initial probability distribution of techniques; generating a hidden Markov model correlating a target sequence of observations with a hidden state sequence of techniques based on the transition probability matrix, the set of emission probability vectors, and the initial technique vector; and calculating a sequence of techniques, based on the hidden Markov model, exhibiting greatest probability to yield, for each technique in the sequence of techniques, absence of detection or prevention of the technique.

Abstract: The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.

Abstract: A method includes: accessing an attack record defining actions representing a previous known attack on a second computer network; initializing an attack graph; for each action, defining a set of behaviors—analogous to the action and executable by an asset on a target network to emulate an effect of the action on the second computer network—and storing the set of behaviors in a node in the attack graph; connecting nodes in the attack graph according to an order of actions in the known attack; scheduling the asset to selectively execute analogous behaviors stored in the set of nodes in the attack graph; accessing alerts generated by a set of security tools deployed on the target network; and characterizing vulnerability of the target network based on alerts, in the set of alerts, indicating detection and prevention of behaviors executed by the asset according to the attack graph.

Abstract: A method includes: accessing an attack record defining actions representing a previous known attack on a second computer network; initializing an attack graph; for each action, defining a set of behaviors—analogous to the action and executable by an asset on a target network to emulate an effect of the action on the second computer network—and storing the set of behaviors in a node in the attack graph; connecting nodes in the attack graph according to an order of actions in the known attack; scheduling the asset to selectively execute analogous behaviors stored in the set of nodes in the attack graph; accessing alerts generated by a set of security tools deployed on the target network; and characterizing vulnerability of the target network based on alerts, in the set of alerts, indicating detection and prevention of behaviors executed by the asset according to the attack graph.

Abstract: A method for automatically converting note-to-self to action reminders in an electronic device is provided. The method includes receiving an input comprising at least one word from a user of the electronic device, analyzing an anaphora representation or a deictic representation for each of the at least one word, and generating a reminder based on a context from the anaphora representation or the deictic representation.

Abstract: The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.

Abstract: A method includes: accessing an attack record defining actions representing a previous known attack on a second computer network; initializing an attack graph; for each action, defining a set of behaviors—analogous to the action and executable by an asset on a target network to emulate an effect of the action on the second computer network—and storing the set of behaviors in a node in the attack graph; connecting nodes in the attack graph according to an order of actions in the known attack; scheduling the asset to selectively execute analogous behaviors stored in the set of nodes in the attack graph; accessing alerts generated by a set of security tools deployed on the target network; and characterizing vulnerability of the target network based on alerts, in the set of alerts, indicating detection and prevention of behaviors executed by the asset according to the attack graph.

Abstract: A nail display device comprising a display configured to be removably mounted relative to a nail of a user, and at least one control board associated with the display to control media displayed on the display.

Abstract: This disclosure describes techniques for enabling interoperability between asymmetric and symmetric Integrated Routing and Bridging (IRB) modes. An interfacing component may be configured to receive a first route advertisement from a first edge node in a Layer-2 (L2) fabric. The first route advertisement may correspond to an asymmetric format route, for instance. The interfacing component may be further configured to receive a second route advertisement from a second edge node in a L2/Layer-3 (L3) fabric. The second edge node may be configured for symmetric integrated routing and bridging (IRB). The interfacing component may be configured to re-originate the first route and the second route such that the interfacing component is included as a hop in the resultant routes between the L2 fabric and the L2/L3 fabric.

Abstract: The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.

Abstract: Presented herein are techniques to support service chains in a network, such as a spine-leaf switch fabric network, that also uses overlay networking technology. More specifically, in accordance with the techniques presented herein, a linecard at an ingress network node for an overlay network is configured to receive a packet. Using information obtained from the packet, a hardware lookup is performed at the linecard to identify a service chain with which the packet is associated. An entry corresponding to the identified service chain is identified within a memory location of the linecard, where the entry includes overlay network information for forwarding packets along the identified service chain via an overlay network. Using the overlay network information included in the identified entry, the packet is encapsulated with an overlay packet header for use in forwarding the packet via the overlay network.

Abstract: The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.

Abstract: A first network device advertises routes of locally connected routes/subnetworks based on the connectivity of the host with respect to peer network devices. The first network device establishes a virtual port channel associated with a virtual network address. The virtual port channel includes the first network device associated with a first network address and a second network device associated with a second network address. The first network device detects that a host is connected to the first network device and determines a next hop address to associate with the host. The next hop address is determined based on whether the host is also connected to the second network device of the virtual port channel. The first network device generates a route advertisement associating the next hop address with the host.

Abstract: A first network device advertises routes of locally connected routes/subnetworks based on the connectivity of the host with respect to peer network devices. The first network device establishes a virtual port channel associated with a virtual network address. The virtual port channel includes the first network device associated with a first network address and a second network device associated with a second network address. The first network device detects that a host is connected to the first network device and determines a next hop address to associate with the host. The next hop address is determined based on whether the host is also connected to the second network device of the virtual port channel. The first network device generates a route advertisement associating the next hop address with the host.