Patents by Inventor Rajiv Bhalla
Rajiv Bhalla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220031870Abstract: A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilized to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: ApplicationFiled: August 5, 2021Publication date: February 3, 2022Inventors: Rajiv BHALLA, Gill REID, William LEVASON
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Patent number: 11135322Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: GrantFiled: January 22, 2013Date of Patent: October 5, 2021Assignees: GE Healthcare Limited, University of SouthamptonInventors: Rajiv Bhalla, Sajinder Kaur Luthra, Gill Reid, I, William Levason
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Patent number: 11103604Abstract: A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: GrantFiled: May 2, 2014Date of Patent: August 31, 2021Assignees: GE HEALTHCARE UK LIMITED, University of SouthamptonInventors: Rajiv Bhalla, Gill Reid, William Levason
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Patent number: 9533059Abstract: The present invention relates to imaging agent compositions comprising radiolabelled c-Met binding peptides suitable for positron emission tomography (PET) imaging in vivo. The c-Met binding peptides are labelled with the radioisotope 18F. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the management of cancer.Type: GrantFiled: August 11, 2011Date of Patent: January 3, 2017Assignee: GE HEALTHCARE LIMITEDInventors: Peter Brian Iveson, Rajiv Bhalla, Bard Indrevall, Gareth Getvoldsen
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Publication number: 20160082136Abstract: A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: ApplicationFiled: May 2, 2014Publication date: March 24, 2016Inventors: Rajiv BHALLA, Gill REID, William LEVASON
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Publication number: 20160074540Abstract: A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: ApplicationFiled: May 2, 2014Publication date: March 17, 2016Inventors: Rajiv BHALLA, Gill REID, William LEVASON
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Patent number: 9259496Abstract: The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.Type: GrantFiled: March 2, 2012Date of Patent: February 16, 2016Assignee: GE Healthcare LimitedInventors: Peter Brian Iveson, Bard Indrevoll, Ben Newton, Rajiv Bhalla, Edvin Wilhelm Johannesen
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Publication number: 20160022845Abstract: The present invention relates to an improved [18F]labelled synthon composition, wherein the non-radioactive impurities in said composition have been found to be more straightforward to remove than with known compositions comprising said [18F]labelled synthon. The resultant purified [18F]label led synthon therefore can be used in the production of a positron emission tomography (PET) tracer having improved properties for in vivo imaging. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.Type: ApplicationFiled: March 28, 2013Publication date: January 28, 2016Applicant: GE HEALTHCARE LIMITEDInventors: RAJIV BHALLA, ALEXANDER JACKSON, GARETH SMITH
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Patent number: 9125954Abstract: The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.Type: GrantFiled: October 15, 2012Date of Patent: September 8, 2015Assignee: GE Healthcare LimitedInventors: Rajiv Bhalla, Anthony Wilson, Imtiaz Khan, Janne Brown
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Patent number: 9085518Abstract: The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.Type: GrantFiled: October 15, 2012Date of Patent: July 21, 2015Assignee: GE Healthcare LimitedInventors: Robert James Domett Nairne, Rajiv Bhalla, Imtiaz Khan, Jane Brown, Anthony Wilson, Andres Black
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Publication number: 20150191477Abstract: The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuticals by nucleophilic fluorination, specifically for use in Positron Emission Tomography (PET).Type: ApplicationFiled: March 16, 2015Publication date: July 9, 2015Applicant: GE HEALTHCARE LIMITEDInventors: Alexander Jackson, Rajiv Bhalla
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Patent number: 9061080Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: GrantFiled: December 19, 2011Date of Patent: June 23, 2015Assignee: GE HEALTHCARE LIMITEDInventors: Duncan Hiscock, Bard Indrevoll, Peter Iveson, Matthias Eberhard Glaser, Rajiv Bhalla, Anthony Wilson
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Patent number: 8980221Abstract: The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuticals by nucleophilic fluorination, specifically for use in Positron Emission Tomography (PET).Type: GrantFiled: December 22, 2008Date of Patent: March 17, 2015Assignee: GE Healthcare LimitedInventors: Alexander Jackson, Rajiv Bhalla
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Publication number: 20140377178Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: ApplicationFiled: January 22, 2013Publication date: December 25, 2014Applicants: UNIVERSITY OF SOUTHAMPTON, GE HEALTHCARE LIMITEDInventors: Rajiv Bhalla, Sajinder Kaur Luthra, Gill Reid, I, William Levason
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Publication number: 20140243555Abstract: The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised.Type: ApplicationFiled: October 15, 2012Publication date: August 28, 2014Applicant: GE HEALTHCARE LIMITEDInventors: Robert James Domett Nairne, Rajiv Bhalla, Imtiaz Khan, Jane Brown, Anthony Wilson, Andres Black
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Publication number: 20140235861Abstract: The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised.Type: ApplicationFiled: October 15, 2012Publication date: August 21, 2014Applicant: GE HEALTHCARE LIMITEDInventors: RAJIV Bhalla, Anthony Wilson, Imtiaz Khan, Janne Brown
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Publication number: 20140097078Abstract: A click chemistry process to be performed with an automated synthesis device using a synthesis cassette includes the steps of performing a chemical reaction in a first vessel at a first elevated temperature, heating the first vessel to a second elevated temperature to cause distillation, delivering a distilled reaction product from the first vessel to a second vessel, performing a click chemistry reaction with the distilled reaction product in the second vessel, purifying the click chemistry product, and formulating a final product from the purified click chemistry product. A cassette and a kit of parts for performing the process are also provided.Type: ApplicationFiled: June 7, 2012Publication date: April 10, 2014Applicant: GE HEALTHCARE LIMITEDInventors: Lisa Iddon, Rajiv Bhalla, ANTHONY Wilson
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Publication number: 20140004041Abstract: The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.Type: ApplicationFiled: March 2, 2012Publication date: January 2, 2014Applicant: GE HEALTHCARE LIMITEDInventors: Peter Brian Iveson, Bard Indrevoll, Ben Newton, Rajiv Bhalla, Edvin Wilhelm Johannesen
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Publication number: 20130295010Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: ApplicationFiled: December 19, 2011Publication date: November 7, 2013Inventors: Duncan Hiscock, Bard Indrevoll, Peter Iveson, Matthias Eberhard Glaser, Rajiv Bhalla, Anthony Wilson
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Publication number: 20130287685Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: ApplicationFiled: December 19, 2011Publication date: October 31, 2013Applicant: GE HEALTHCARE LIMITEDInventors: Duncan Hiscock, Brad Indrevoll, Peter Iveson, Matthias Eberhard Glaser, Rajiv Bhalla, Anthony Wilson