Patents by Inventor Raju Mohan

Raju Mohan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azepinoindole Derivatives As Pharmaceutical Agents
    Publication number: 20090203577
    Abstract: The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.
    Type: Application
    Filed: December 12, 2006
    Publication date: August 13, 2009
    Applicant: EXELIXIS, INC.
    Inventors: Tae-Gon Baik, Chris A. Buhr, Brett B. Busch, Diva Sze-Ming Chan, Brenton T. Flatt, Xiao-Hui Gu, Vasu Jammalamadaka, Richard George Khoury, Katherine Lara, Sunghoon Ma, Richard Martin, Raju Mohan, John M. Nuss, Jason Jevious Parks, Jason H. Wu, Bryan K. S. Yeung, Wei Xu, Tie-Lin Wang, Longcheng Wang
  • Pharmaceutical Compositions
    Publication number: 20090197870
    Abstract: Compounds for use in compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the estrogen related receptors are provided. In one embodiment, the compounds provided herein are ERR modulators. In another embodiment, the compounds provided herein are agonists, partial agonists, antagonists, or inverse agonists of ERR or ERR?. In certain embodiments, the compounds of the invention, as described above in the Summary of the Invention, are compounds of formula (I).
    Type: Application
    Filed: October 21, 2005
    Publication date: August 6, 2009
    Applicant: EXELIXIS, INC.
    Inventors: Richard Martin, Raju Mohan, Brett B. Busch, Michael Charles Nyman, William C. Stevens, JR.
  • Plasma carboxypeptidase B inhibitors
    Patent number: 7528173
    Abstract: Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: May 5, 2009
    Assignee: Schering Aktiengesellshaft
    Inventors: Brad Buckman, Kumar Emayan, Imadul Islam, Karen May, Judi Bryant, Raju Mohan, Christopher West, Shendong Yuan
  • PLASMA CARBOXYPEPTIDASE B INHIBITORS
    Publication number: 20090093520
    Abstract: Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    Type: Application
    Filed: December 11, 2008
    Publication date: April 9, 2009
    Inventors: Brad BUCKMAN, Kumar Emayan, Imadul Islam, Karen May, Judi Bryant, Raju Mohan, Christopher West, Shendon Yuan
  • Modulators of LXR
    Patent number: 7482366
    Abstract: Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
    Type: Grant
    Filed: July 24, 2004
    Date of Patent: January 27, 2009
    Assignee: X-Ceptor Therapeutics, Inc.
    Inventors: Christopher D Bayne, Alan T Johnson, Shao-Po Lu, Raju Mohan, Michael C Nyman, Edwin J Schweiger, William C Stevens, Jr., Haixia Wang, Yinong Xie
  • Pyrrole Derivatives As Pharmaceutical Agents
    Publication number: 20080234270
    Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
    Type: Application
    Filed: July 30, 2005
    Publication date: September 25, 2008
    Applicant: EXELIXIS, INC.
    Inventors: Lynne Canne Bannen, Jeff Chen, Lisa Esther Dalrymple, Brenton T. Flatt, Timothy Patrick Forsyth, Xiao-Hui Gu, Morrison B. Mac, Larry W. Mann, Grace Mann, Richard Martin, Raju Mohan, Brett Murphy, Michael Charles Nyman, William C. Stevens, Tie-Lin Wang, Yong Wang, Jason H. Wu
  • Isoquinolinone Derivatives and Their Use As Therapeutic Agents
    Publication number: 20080132521
    Abstract: Compounds of formula (I): wherein n, R1, R2, R3 and R7 are disclosed herein, are useful in treating disease-states associated with nuclear receptor activity. Pharmaceutical compositions comprising and methods of using said compounds are also disclosed herein.
    Type: Application
    Filed: July 27, 2007
    Publication date: June 5, 2008
    Applicant: EXELIXIS, INC.
    Inventors: Alan T. Johnson, Satoru Kaneko, Raju Mohan, Kozo Oda, Edwin J. Schweiger
  • Modulators Of Nuclear Receptors
    Publication number: 20080119488
    Abstract: Compounds of the invention, such as compounds of formula (I), where n, m, A, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
    Type: Application
    Filed: July 24, 2005
    Publication date: May 22, 2008
    Applicant: EXELIXIS, INC.
    Inventors: Christopher D. Bayne, Alan T. Johnson, Shao-Po Lu, Raju Mohan, Michael C. Nyman, Edwin J. Schweiger, William C. Stevens, Haixia Wang, Yinong Xie, Lynne Canne Bannen, Diva Sze-Ming Chan, Ping Huang, Vasu Jammalamadaka, Richard G. Khoury, Morrison B. Mac, Jason Jevious Parks, Yong Wang, Wei Xu
  • Substituted Pyrimidine Compositions and Methods of Use
    Publication number: 20070293464
    Abstract: Novel compositions and methods of using substituted pyrimidines which have the general formula: (I)
    Type: Application
    Filed: November 9, 2004
    Publication date: December 20, 2007
    Applicant: X-Ceptor Therapeutics, Inc.
    Inventors: Richard Martin, Raju Mohan, Peter Ordentlich
  • Bridged Ring Structures as Pharmaceutical Agents
    Publication number: 20070225377
    Abstract: The present invention is directed to 1?,25-dihydroxyvitamin D3 mimics which modulate the vitamin D receptor (VDR). The invention is further directed to pharmaceutical compositions and methods for the treatment, prevention or amelioration of one or more symptoms of disease or disorder related to the activity of the vitamin D receptor using an effective amount of a compound of formula (I).
    Type: Application
    Filed: October 13, 2004
    Publication date: September 27, 2007
    Applicant: X-Ceptor Therapeutics, Inc.
    Inventors: Brenton Flatt, Richard Martin, Raju Mohan, Brett Murphy
  • Isoquinolinone derivatives and their use as therapeutic agents
    Patent number: 7265131
    Abstract: Compounds of formula (I): wherein n, R1, R2, R3 and R7 are disclosed herein, are useful in treating disease-states associated with nuclear receptor activity. Pharmaceutical compositions comprising and methods of using said compounds are also disclosed herein.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: September 4, 2007
    Assignee: Exelixis, Inc.
    Inventors: Alan T Johnson, Satoru Kaneko, Raju Mohan, Kozo Oda, Edwin J Schweiger
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 7202263
    Abstract: N-Heterocyclic derivatives of the following formula: where m, n, p, A1, R1, R2, R3 and R4 are described herein, as well as other N-heterocyclic derivatives, are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: April 10, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: David Davey, Raju Mohan, Gary Phillips, Guo Ping Wei, Wei Xu
  • Imidazolidinedione analogs useful as anticoagulants and antithrombotics
    Patent number: 7199146
    Abstract: A compound is disclosed, which is useful in treating a mammal having a disease-state characterized by thrombotic activity. The compound is of the following formula: wherein A, B, R1, R2, R3 and R4 are as defined herein or an isomer or isomeric mixture thereof or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: April 3, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: Damian O. Arnaiz, Yuo-Ling Chou, Brian Griedel, Raju Mohan, Kenneth J. Shaw
  • Platelet adenosine diphosphate receptor antagonists
    Patent number: 7176207
    Abstract: Compounds of the following formula (I): where A, a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: February 13, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: Judi A Bryant, Brad O Buckman, Imadul Islam, Raju Mohan, Michael M Morrissey, Robert Guo-Ping Wei, Wei Xu, Shendong Yuan
  • Plasma carboxypeptidase b inhibitors
    Publication number: 20060247213
    Abstract: Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    Type: Application
    Filed: March 21, 2003
    Publication date: November 2, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Brad Buckman, Kumar Emayan, Imadul Islam, Karen May, Judi Bryant, Raju Mohan, Christopher West, Shendong Yuan
  • Platelet adenosine diphosphate receptor antagonists
    Patent number: 7084142
    Abstract: Compounds of the following formula: where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: August 1, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Judi Bryant, Brad Buckman, Imadul Islam, Raju Mohan, Michael Morrissey, Guo Ping Wei, Wei Xu, Shendong Yuan
  • Imidazolidinedione analogs useful as anticoagulants and antithrombotics
    Publication number: 20060142363
    Abstract: A compound is disclosed, which is useful in treating a mammal having a disease-state characterized by thrombotic activity. The compound is of the following formula: wherein A, B, R1, R2, R3 and R4 are as defined herein or an isomer or isomeric mixture thereof or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 22, 2006
    Publication date: June 29, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Damian Arnaiz, Yuo-Ling Chou, Brian Griedel, Raju Mohan, Kenneth Shaw
  • Platelet adenosine diphosphate receptor antagonists
    Publication number: 20060135532
    Abstract: Compounds of the following formula (I): where A, a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    Type: Application
    Filed: February 2, 2006
    Publication date: June 22, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Judi Bryant, Brad Buckman, Imadul Islam, Raju Mohan, Michael Morrissey, Guo Ping Wei, Wei Xu, Shendong Yuan
  • Platelet adenosine diphosphate receptor antagonists
    Publication number: 20060122188
    Abstract: Compounds of the following formula: where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    Type: Application
    Filed: January 12, 2006
    Publication date: June 8, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Judi Bryant, Brad Buckman, Imadul Islam, Raju Mohan, Michael Morrissey, Guo Wei, Wei Xu, Shendong Yuan
  • Platelet adenosine diphosphate receptor antagonists
    Patent number: 7056923
    Abstract: Compounds of the following formula: where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: June 6, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Judi Bryant, Brad Buckman, Imadul Islam, Raju Mohan, Michael Morrissey, Guo Ping Wei, Wei Xu, Shendong Yuan