Patents by Inventor Ralf Heim
Ralf Heim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11167933Abstract: A method for transferring medical products comprises the steps of conveying medical products on an oscillating conveyor having a plurality of conveying lanes arranged next to each other to a delivery area of the conveyor lanes and from the delivery area into at least one shaft; detecting a defective product in one of the conveying lanes; and activating a diverter device for defective products, which is arranged adjacent to the delivery area of this conveying lane, when a defective product is detected, wherein the diverter device, upon activation, is shifted or pivoted into an activated position, in which the diverter device is located in a transport path of the defective product.Type: GrantFiled: June 19, 2020Date of Patent: November 9, 2021Assignee: Uhlmann Pac-Systeme Gmb H & Co. KGInventors: Ralf Heim, Michael Kronawitter
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Publication number: 20200399074Abstract: A method for transferring medical products comprises the steps of conveying medical products on an oscillating conveyor having a plurality of conveying lanes arranged next to each other to a delivery area of the conveyor lanes and from the delivery area into at least one shaft; detecting a defective product in one of the conveying lanes; and activating a diverter device for defective products, which is arranged adjacent to the delivery area of this conveying lane, when a defective product is detected, wherein the diverter device, upon activation, is shifted or pivoted into an activated position, in which the diverter device is located in a transport path of the defective product.Type: ApplicationFiled: June 19, 2020Publication date: December 24, 2020Inventors: Ralf Heim, Michael Kronawitter
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Patent number: 10336516Abstract: Childproof safety cap has two opposite bead-like threads on its inner wall. Each thread has a widened end region, a stop surface thus being formed. The associated bottle has two opposite groove-like threads on a connecting piece of the bottle, each of which threads has a widened region in the end region, an undercut thus being formed in the groove by the widened region. When the safety cap is screwed on, the stop surfaces on the two bead-like threads hook in behind the undercuts on the groove-like threads. The stop surfaces can be released from each other only if the safety cap is pressed down toward the bottle onto the connecting-piece neck. Connecting-piece neck forms a slipping surface that conically expands downwards. The safety cap can then be unscrewed while simultaneously being rotated.Type: GrantFiled: December 17, 2015Date of Patent: July 2, 2019Assignee: AERO PUMP GMBHInventors: Ralf Heim, Andreas Mersmann
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Publication number: 20180016067Abstract: Childproof safety cap having two opposite bead-like threads on its inner wall. Each thread has a widened end region, a stop surface thus being formed. The associated bottle has two opposite groove-like threads on a connecting piece of said bottle, each of which threads has a widened region in the end region, an undercut thus being formed in the groove by the widened region. When the safety cap is screwed on, the stop surfaces on the two bead-like threads hook in behind the undercuts on the groove-like threads. The stop surfaces can be released from each other only if the safety cap is pressed down toward the bottle onto the connecting-piece neck. Connecting-piece neck forms a slipping surface that conically expands downwards. The safety cap can then be unscrewed while simultaneously being rotated.Type: ApplicationFiled: December 17, 2015Publication date: January 18, 2018Applicant: AERO PUMP GMBHInventors: Ralf HEIM, Andreas MERSMANN
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Patent number: 9745282Abstract: This invention relates to indoline compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.Type: GrantFiled: June 30, 2016Date of Patent: August 29, 2017Assignees: Merck Sharp & Dohme Corp, ElexoPharm GmbHInventors: Amjad Ali, Michael Man-Chu Lo, Edward Metzger, Lina Yin, Rolf Hartmann, Qingzhong Hu, Ralf Heim, Christina Zimmer
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Patent number: 9550750Abstract: This invention relates to indo line compounds of the structural formula I, or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.Type: GrantFiled: October 2, 2013Date of Patent: January 24, 2017Assignees: Merck Sharp & Dohme Corp., Elexopharm GMBHInventors: Amjad Ali, Michael Man-Chu Lo, Edward Metzger, Lina Yin, Rolf Hartmann, Qingzhong Hu, Ralf Heim, Christina Zimmer
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Publication number: 20160304486Abstract: This invention relates to indoline compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.Type: ApplicationFiled: June 30, 2016Publication date: October 20, 2016Inventors: Amjad Ali, Michael Man-Chu Lo, Edward Metzger, Lina Yin, Rolf Hartmann, Qingzhong Hu, Ralf Heim, Christina Zimmer
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Patent number: 9399532Abstract: The invention pertains to a system for filling bottle-like containers with tablets, which comprises various devices for specific processes, wherein most of the devices have a transport mechanism for positively guiding the movement of each container by itself in a continuous manner, whereas at least the device for dosing the pharmaceutical products and for introducing the pharmaceutical products into the containers has a transport mechanism for positively guiding the movement of each container by itself in a clocked manner in certain sections. The transport mechanisms of the devices are connected to each other in series, which ensures the positive guidance of each individual container by itself through the entire system.Type: GrantFiled: June 6, 2008Date of Patent: July 26, 2016Assignee: Uhlmann Pac-Systeme GmbH & Co. KGInventors: Joachim Noe, Michael Kronawitter, Ralf Heim, Rita Hagel, Rolf Armbruster
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Publication number: 20150225365Abstract: This invention relates to indo line compounds of the structural formula I, or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.Type: ApplicationFiled: October 2, 2013Publication date: August 13, 2015Applicants: ElexoPharm GmbH, Merck Sharp & Dohme Corp.Inventors: Amjad Ali, Michael Man-Chu Lo, Edward Metzger, Lina Yin, Rolf Hartmann, Qingzhong Hu, Ralf Heim, Christina Zimmer
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Patent number: 9073929Abstract: This invention relates to tricyclic triazole analogs of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.Type: GrantFiled: April 20, 2012Date of Patent: July 7, 2015Assignees: ElexoPharm GmbH, Merck Sharp & Dohme Corp.Inventors: Scott B. Hoyt, Whitney Lane Petrilli, Clare London, Yusheng Xiong, Jerry Andrew Taylor, Amjad Ali, Michael Man-Chu Lo, Timothy J. Henderson, Qingzhong Hu, Rolf Hartmann, Lina Yin, Ralf Heim, Emmanuel Bey, Rohit Saxena, Swapan Kumar Samanta, Bheemashankar A. Kulkarni
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Patent number: 8685960Abstract: The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 ?-hydroxylase (CYP11 B1).Type: GrantFiled: May 5, 2009Date of Patent: April 1, 2014Assignee: Elexopharm GmbHInventors: Rolf W. Hartmann, Ralf Heim, Simon Lucas
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Patent number: 8678175Abstract: The device for channeling out upright containers from a first transport device, which moves the container in a transport direction, includes a lateral guide section, which extends in the transport direction, and a gripper unit, which has a plurality of grippers for gripping the containers. The lateral guide section and the gripper unit are moved from a pickup position for the containers jointly in a direction transverse to the transport direction. After this joint movement the gripper unit is moved towards a discharge position for the containers. The lateral guide section and the gripper unit are then moved back to the pickup position.Type: GrantFiled: February 9, 2012Date of Patent: March 25, 2014Assignee: Uhlmann Pac-Systeme GmbH & Co. KG.Inventors: Ralf Heim, Joachim Noe
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Publication number: 20140045819Abstract: This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.Type: ApplicationFiled: April 20, 2012Publication date: February 13, 2014Applicants: ElexoPharm GmbH, SCHERING CORPORATIONInventors: Scott B. Hoyt, Whitney Lane Petrilli, Clare London, Yusheng Xiong, Jerry Andrew Taylor, Amjad Ali, Michael Man-Chu Lo, Timothy J. Henderson, Qingzhong Hu, Rolf Hartmann, Lina Yin, Ralf Heim, Emmanuel Bey, Rohit Saxena, Swapan Kumar Samanta, Bheemashankar A. Kulkarni
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Patent number: 8541404Abstract: The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and/or disorders or diseases that are mediated by 11?-hydroxylase (CYP11B1) with these compounds.Type: GrantFiled: November 3, 2010Date of Patent: September 24, 2013Assignee: ElexoPharm GmbHInventors: Rolf W. Hartmann, Ralf Heim, Simon Lucas
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Patent number: 8534453Abstract: The device for transporting upright containers in a straight line includes a rake conveyor comprising multiple receiving sections for the containers and an opposing support element for the containers carried in the receiving sections. The rake conveyor is connected to two drives by at least two pivot systems, each with two arms, in such a way that the rake conveyor can be pushed back and forth both in the transport direction of the containers and also in the direction perpendicular to the transport direction of the containers.Type: GrantFiled: February 9, 2012Date of Patent: September 17, 2013Assignee: Uhlmann Pac-Systeme GmbH & Co. KGInventors: Juergen Liebhardt, Michael Kronawitter, Ralf Heim
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Patent number: 8403009Abstract: A method for filling a plurality of containers in cycles at a predetermined number of stationary filling units arranged in a row with a first spacing from each other. The method includes providing a plurality of positively guided containers in a row, one-by-one, wherein the containers have a uniform second spacing from each other, wherein the first spacing of the individual filling units is a whole-number multiple of the second spacing of the containers, and filling a predetermined number of the containers simultaneously at the filling units. The containers are shifted in cycles along the filling units in a transport direction by a step length, which is a whole-number multiple of the second spacing of the containers and which is shorter than a third spacing between a first filling unit and a last filling unit steps of filling and shifting are repeated over a predetermined number of iterations.Type: GrantFiled: August 10, 2009Date of Patent: March 26, 2013Assignee: Uhlmann Pac-Systems GmbH & Co. KGInventors: Joachim Noe, Thomas Ruelker, Ralf Heim
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Publication number: 20120222941Abstract: The device for transporting upright containers in a straight line includes a rake conveyor comprising multiple receiving sections for the containers and an opposing support element for the containers carried in the receiving sections. The rake conveyor is connected to two drives by at least two pivot systems, each with two arms, in such a way that the rake conveyor can be pushed back and forth both in the transport direction of the containers and also in the direction perpendicular to the transport direction of the containers.Type: ApplicationFiled: February 9, 2012Publication date: September 6, 2012Applicant: UHLMANN PAC-SYSTEME GMBH & CO. KGInventors: Juergen Liebhardt, Michael Kronawitter, Ralf Heim
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Publication number: 20120222939Abstract: The device for channeling out upright containers from a first transport device, which moves the container in a transport direction, includes a lateral guide section, which extends in the transport direction, and a gripper unit, which has a plurality of grippers for gripping the containers. The lateral guide section and the gripper unit are moved from a pickup position for the containers jointly in a direction transverse to the transport direction. After this joint movement the gripper unit is moved towards a discharge position for the containers. The lateral guide section and the gripper unit are then moved back to the pickup position.Type: ApplicationFiled: February 9, 2012Publication date: September 6, 2012Applicant: UHLMANN PAC-SYSTEME GMBH & CO. KG.Inventors: Ralf Heim, Joachim Noe
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Publication number: 20110118241Abstract: The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 ?-hydroxylase (CYP11 B1).Type: ApplicationFiled: May 5, 2009Publication date: May 19, 2011Applicant: Universitat des SaarlandesInventors: Rolf W. Hartmann, Ralf Heim, Simon Lucas
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Publication number: 20110112067Abstract: The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and/or disorders or diseases that are mediated by 11?-hydroxylase (CYP11B1) with these compounds.Type: ApplicationFiled: November 3, 2010Publication date: May 12, 2011Applicant: Universitat des SaarlandesInventors: Rolf W. Hartmann, Ralf Heim, Simon Lucas