Patents by Inventor Ralf Jauch

Ralf Jauch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS TO CONVERT SOMATIC HUMAN CELL TO A TOTIPOTENCY-LIKE STATE WITH ENGINEERED SOX17
    Publication number: 20240084265
    Abstract: Compositions of transcription factor cocktails including engineered SOX17 factor (eSOX17), together with one or more of OCT4, KLF4, and C-MYC, and vectors carrying one or more of these transcription factors suitable for delivery to donor somatic cells for generating induced expanded potential stem cells (iEPSCs) or induced neural stem cells (iNSCs) are provided. The disclosed compositions deliver reprograming of human somatic cells into a totipotency-like, or multipotency-like state with improved efficiency. Compositions of eSOX17-derived iEPSCs and iNSCs generated according to the described methods are also described. The methods engineer somatic cells to express one or more markers of pluripotency or neural stem cells. Methods of using iEPSCs or iNSCs in studying early human development and in cell therapy are also provided.
    Type: Application
    Filed: August 21, 2023
    Publication date: March 14, 2024
    Inventors: Ralf Jauch, Haoqing Hu, Mingxi Weng, Hoi Hang Ho
  • Mutant sox proteins and methods of inducing pluripotency
    Patent number: 8907055
    Abstract: There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one aspect, the Oct4 contact interface of Sox7 or Sox17 is mutated. In another aspect, the high mobility group (HMG) of Sox2 is fused to the C-terminal activation domain of Sox7 or Sox17. Methods relating to inducing pluripotency using a mutant Sox2, Sox7 or Sox17 protein are also provided.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: December 9, 2014
    Assignee: Agency for Science, Technology and Research
    Inventors: Prasanna R. Kolatkar, Irene Aksoy, Ralf Jauch, Lawrence W. Stanton
  • MUTANT SOX PROTEINS AND METHODS OF INDUCING PLURIPOTENCY
    Publication number: 20120220029
    Abstract: There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one aspect, the Oct4 contact interface of Sox7 or Sox17 is mutated. In another aspect, the high mobility group (HMG) of Sox2 is fused to the C-terminal activation domain of Sox7 or Sox17. Methods relating to inducing pluripotency using a mutant Sox2, Sox7 or Sox17 protein are also provided.
    Type: Application
    Filed: November 4, 2010
    Publication date: August 30, 2012
    Applicant: Agency for Science, Technology and Research
    Inventors: Prasanna R. Kolatkar, Irene Aksoy, Ralf Jauch, Lawrence W. Stanton
  • Crystallographic structure of Mnk-1 and Mnk-2 proteins
    Patent number: 8129164
    Abstract: The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: March 6, 2012
    Assignees: Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.V., Boehringer Ingelheim International GmbH
    Inventors: Markus Wahl, Ralf Jauch, Kay Schreiter, Stefan Jakel
  • Crystallographic Structure of Mnk-1 and Mnk-2 Proteins
    Publication number: 20110159568
    Abstract: The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain.
    Type: Application
    Filed: February 8, 2011
    Publication date: June 30, 2011
    Inventors: Markus Wahl, Ralf Jauch, Kay Schreiter, Stefan Jäkel
  • Crystallographic structure of Mnk-1 and Mnk-2 proteins
    Patent number: 7943357
    Abstract: The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: May 17, 2011
    Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V., Boehringer Ingelheim International GmbH
    Inventors: Markus Wahl, Ralf Jauch, Kay Schreiter, Stefan Jäkel
  • Crystallographic Structure of MNK-1 and MNK-2 Proteins
    Publication number: 20090104679
    Abstract: The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain.
    Type: Application
    Filed: March 8, 2006
    Publication date: April 23, 2009
    Inventors: Markus Wahl, Ralf Jauch, Schreiter Kay, Jakel Stefan