Patents by Inventor RALF KIRCHEIS

RALF KIRCHEIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glyco-engineered antibodies
    Patent number: 10253098
    Abstract: The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: April 9, 2019
    Assignee: GREENOVATION BIOTECH GMBH
    Inventors: Manfred Schuster, Ralf Kircheis, Andreas Nechansky, Wolfgang Jost, Gilbert Gorr
  • Glyco-Engineered Antibodies
    Publication number: 20150284461
    Abstract: The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.
    Type: Application
    Filed: May 28, 2015
    Publication date: October 8, 2015
    Applicant: GREENOVATION BIOTECH GMBH
    Inventors: Manfred Schuster, Ralf Kircheis, Andreas Nechansky, Wolfgang Jost, Gilbert Gorr
  • Nanoparticles comprising antigens and adjuvants, and immunogenic structures
    Patent number: 9079765
    Abstract: Nanoparticles comprising adjuvants and antigens, such as tumor and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: July 14, 2015
    Assignee: Midatech Ltd.
    Inventors: Gottfried Himmler, G. C. Mudde, Ralf Kircheis, Thomas William Rademacher, Soledad Penades Ullate, Manuel Martin Lomas, Jose Luis De Paz Carrera, Rafael Ojeda Martinez De Castilla, Africa Garcia Barrientes
  • Glyco-engineered antibodies
    Patent number: 9051577
    Abstract: The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that • the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and • at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: June 9, 2015
    Assignee: GREENOVATION BIOTECH GMBH
    Inventors: Manfred Schuster, Ralf Kircheis, Andreas Nechansky, Wolfgang Jost, Gilbert Gorr
  • IMMUNOGENIC, MONOCLONAL ANTIBODY
    Publication number: 20100310551
    Abstract: The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
    Type: Application
    Filed: March 29, 2010
    Publication date: December 9, 2010
    Applicants: MERIDIAN BIOPHARMACEUTICALS GmbH, GREENOVATION BIOTECH GmbH
    Inventors: Hans LOIBNER, Günter WAXENECKER, Gottfried HIMMLER, Helmut ECKERT, Manfred SCHUSTER, Ralf KIRCHEIS
  • GLYCO-ENGINEERED ANTIBODIES
    Publication number: 20090291078
    Abstract: The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that • the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and • at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.
    Type: Application
    Filed: July 11, 2007
    Publication date: November 26, 2009
    Applicant: GREENOVATION BIOTECH GMBH
    Inventors: Manfred Schuster, Ralf Kircheis, Andreas Nechansky, Wolfgang Jost, Gilbert Gorr
  • Nanoparticles Comprising Antigens and Adjuvants, and Immunogenic Structures
    Publication number: 20090104268
    Abstract: Nanoparticles comprising adjuvants and antigens, such as tumour and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.
    Type: Application
    Filed: September 30, 2005
    Publication date: April 23, 2009
    Applicant: Midatech Limited
    Inventors: Gottfried Himmler, G. C. Mudde, Ralf Kircheis, Thomas William Rademacher, Soledad Penades Ullate, Manuel Martin Lomas, Jose Luis De Paz Carrera, Rafael Ojeda Martinez De Castilla, Africa Garcia Barrientes
  • Immunogenic monoclonal antibody
    Publication number: 20050181475
    Abstract: The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
    Type: Application
    Filed: May 15, 2003
    Publication date: August 18, 2005
    Applicant: Igeneon Krebs-Immuntherapie Forschungs-Und-Entwicklungs-AG
    Inventors: Hans Loibner, Gunter Waxenecker, Gottfried Himmler, Helmut Eckert, Manfred Schuster, Ralf Kircheis
  • Complexes for transporting nucleic acid into eukaryotic higher-cells
    Publication number: 20040248842
    Abstract: Complexes of nucleic acid and polyethyleneimine (PEI), wherein PEI is modified with a hydrophilic polymer covalently coupled thereto, such as polyethyleneglycol, and processes for preparing them. A cellular ligand such as transferrin is optionally coupled to PEI. The complexes may be used for preparing pharmaceutical compositions for transferring therapeutically effective genes into mammalian cells.
    Type: Application
    Filed: July 6, 2004
    Publication date: December 9, 2004
    Applicant: Boehringer Ingelheim Internation GmbH
    Inventors: Ernst Wagner, Manfred Ogris, Ralf Kircheis, Sylvia Brunner
  • Method for producing a vaccine
    Publication number: 20040191242
    Abstract: There is disclosed a method of producing an autologous-antibody-containing vaccine, which method is characterized by the following steps:
    Type: Application
    Filed: March 8, 2004
    Publication date: September 30, 2004
    Inventors: Gottried Himmler, Hans Loibner, Helmut Eckert, Otto Doblhoff-Dier, Ralf Kircheis, Manfred Schuster, Erich Wasserbauer, Gunter Waxenecker
  • Transferrin polycation/DNA complexes for the systemic treatment of tumor diseases with cytotoxic proteins
    Publication number: 20020137670
    Abstract: Complex of DNA, containing one or more DNA molecules coding for one or more therapeutically active proteins with a cytotoxic activity, and a polycation conjugated with transferrin with a zeta potential of ≦+15 mV. The complex, in which a high transferrin content screens the positive charge, produces a targeted transportation of the therapeutic DNA to the tumors in the systemic treatment of tumor diseases.
    Type: Application
    Filed: October 3, 2001
    Publication date: September 26, 2002
    Applicant: Boehringer Ingelheim International GmbH.
    Inventors: Ralf Kircheis, Ernst Wagner, Lionel Wightman, Elinborg Ostermann
  • COMPLEXES FOR TRANSPORTING NUCLEIC ACID INTO EUKARYOTIC HIGHER-CELLS
    Publication number: 20010005717
    Abstract: Complexes of nucleic acid and polyethyleneimine (PEI), wherein PEI is modified with a hydrophilic polymer covalently coupled thereto, such as polyethyleneglycol, and processes for preparing them. A cellular ligand such as transferrin is optionally coupled to PEI. The complexes may be used for preparing pharmaceutical compositions for transferring therapeutically effective genes into mammalian cells.
    Type: Application
    Filed: April 17, 2000
    Publication date: June 28, 2001
    Inventors: ERNST WAGNER, MANFRED OGRIS, RALF KIRCHEIS, SYLVIA BRUNNER