Patents by Inventor Ralf Morgenstern

Ralf Morgenstern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN STRUCTURE AND METHOD OF USING PROTEIN STRUCTURE
    Publication number: 20110207113
    Abstract: Methods for building an atomic model of a protein molecule that include: (a) identifying a protein molecule with at least 20% sequence identity to Microsomal Prostaglandin E Synthase 1 (MPGES1) and (b) utilizing the atomic coordinates of MPGES1 to obtain an atomic model of the identified protein molecule are provided. Methods for determining a drug candidate compound that interacts with members of the MAPEG family, in particular MPGES1, are also provided.
    Type: Application
    Filed: January 23, 2009
    Publication date: August 25, 2011
    Applicant: NOVASAID AB
    Inventors: Hans Hebert, Caroline Jegerschold, Per-Johan Jakobsson, Ralf Morgenstern
  • Methods and means for modulating PGE synthase activity
    Patent number: 7645601
    Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: January 12, 2010
    Assignee: Karolinska Innovations AB
    Inventors: Per-Johan Jakobsson, Bengt Samuelsson, Ralf Morgenstern, Anthony Ford-Hutchinson
  • Methods for Building Atomic Models of Protein Molecules and Determining Drug Candidates Using MGST1
    Publication number: 20090104638
    Abstract: Methods for building an atomic model of a protein molecule comprising: (a) identifying a protein molecule with at least 20% sequence identity with Microsomal Glutathione Transferase 1 (MGST1) and (b) utilizing the atomic coordinates of MGST1 to obtain an atomic model of the identified protein molecule and methods for determining a drug candidate compound that interacts with members of the MAPEG superfamily, in particular MGST1 are also provided.
    Type: Application
    Filed: March 22, 2007
    Publication date: April 23, 2009
    Inventors: Hans Hebert, Ralf Morgenstern
  • METHODS AND MEANS FOR MODULATING PGE SYNTHASE ACTIVITY
    Publication number: 20080153107
    Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
    Type: Application
    Filed: February 27, 2007
    Publication date: June 26, 2008
    Inventors: Per-Johan Jakobsson, Bengt Samuelsson, Ralf Morgenstern
  • Methods and means for modulating PGE synthase activity
    Patent number: 7192733
    Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: March 20, 2007
    Assignee: Karolinska Innovations AB
    Inventors: Per-Johan Jakobsson, Bengt Samuelsson, Ralf Morgenstern, Anthony Ford-Hutchinson, Joseph Mancini
  • Methods and means for modulating PGE synthase activity
    Patent number: 7067296
    Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: June 27, 2006
    Assignee: Karolinska Innovations AB
    Inventors: Per-Johan Jakobsson, Bengt Samuelsson, Ralf Morgenstern, Anthony Ford-Hutchinson, Joseph Mancini
  • Methods and means for modulating PGE synthase activity
    Publication number: 20050118696
    Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
    Type: Application
    Filed: October 7, 2004
    Publication date: June 2, 2005
    Inventors: Per-Johan Jakobsson, Bengt Samuelsson, Ralf Morgenstern, Anthony Ford-Hutchinson, Joseph Mancini
  • Methods for preparing purified prostaglandin E synthase
    Publication number: 20030157084
    Abstract: The invention provides purified preparations of prostaglandin E synthase (PGES), analogs and variants thereof, such as portions thereof, and fusion polypeptides comprising these. The invention also provides methods for obtaining these purified preparations; methods for identifying modulators of PGES, e.g., small molecules inhibiting or stimulating the activity of PGES; and methods for preparing prostaglandins. Nucleic acids encoding PGES polypeptides of the invention are also provided.
    Type: Application
    Filed: August 23, 2002
    Publication date: August 21, 2003
    Inventors: Per-Johan Jakobsson, Rolf Weinander, Ralf Morgenstern, Ralph H. Lambalot
  • Methods and means for modulating PGE synthase activity
    Publication number: 20030064493
    Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
    Type: Application
    Filed: March 28, 2002
    Publication date: April 3, 2003
    Inventors: Per-Johan Jakobsson, Bengt Samuelsson, Ralf Morgenstern, Anthony Ford-Hutchinson, Joseph Mancini
  • Method and means for modulating PGE synthase activity
    Patent number: 6395502
    Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: May 28, 2002
    Assignee: Karolinska Innovations AB
    Inventors: Per-Johan Jakobsson, Bengt Samuelsson, Ralf Morgenstern