Abstract: The present invention is related to agents capable of binding to and inhibiting or antagonizing the action of IL-11 and/or or IL-11RA for the treatment and/or prevention of abnormal uterine bleeding, which comprises heavy menstrual bleeding, prolonged bleeding, altered bleeding pattern, dysmenorrhea, as well as of the underlying diseases leiomyoma and endometriosis and the use of the agent to inhibit menstruation. Furthermore, the invention provides novel IL-11 antibodies.

Abstract: A method for producing a capsule, includes providing a base body made of a plastic and having a base region, a circumferential side wall, and a circumferential base body flange adjacent to the circumferential side wall; providing a cover made of a plastic; filling the base body with an extraction material; placing the cover on the base body so that a fastening portion of the cover contacts the base body flange, and fastening the cover flange to the base body flange by ultrasonic welding. When fastening the cover flange, an inner surface of the fastening section makes contact with a flange surface of the base body flange. A sonotrode having mechanical vibrations applied thereto is pressed against an outer surface of the fastening section or of the base body flange, and mechanical vibrations liquefy plastic material of the cover or of the base body flange.

Abstract: A production system for producing a medical device from a tube includes a tube positioning device for positioning the tube. The tube positioning device is configured to hold the tube such that a portion of the tube extends from the tube positioning device along a longitudinal direction. A guiding device is used to guide the portion of the tube, and a laser cutting device is used to form the medical device from the portion of the tube. The guiding device comprises a plurality of bearing elements each configured to abut the portion of the tube and each having a convex curvature in a plane spanned by the longitudinal direction and a transverse direction perpendicular to the longitudinal direction.

Abstract: The invention relates to a wall flow filter for removing particulate matter from the exhaust of internal combustion engines, comprising a wall flow filter substrate having a length L, and different coatings Z and F, the wall flow filter substrate being provided with channels E and A which run parallel between a first end and a second end of the wall flow filter substrate, are separated by porous walls, and form surfaces OE and OA, respectively; channels E are closed at the second end, and channels A are closed at the first end; coating Z is disposed in the porous walls and/or on surfaces OA, but not on surfaces OE, and contains palladium and/or rhodium and a cerium/zirconium mixed oxide; coating F is disposed mainly on surfaces OE, but not on surfaces OA, and comprises a membrane and no precious metal. The wall flow filter is characterized in that the mass ratio of coating Z to coating F ranges from 0.1 to 25.

Abstract: An SiC volume monocrystal is processed by sublimation growth. An SiC seed crystal is placed in a crystal growth region of a growing crucible and SiC source material is introduced into an SiC storage region. During growth, at a growth temperature of up to 2,400° C. and a growth pressure between 0.1 mbar and 100 mbar, an SiC growth gas phase is generated by sublimation of the SiC source material and by transport of the sublimated gaseous components into the crystal growth region, where an SiC volume monocrystal grows by deposition from the SiC growth gas phase on the SiC seed crystal. A mechanical stress is introduced into the SiC seed crystal at room temperature prior to the start of the growth to cause seed screw dislocations present in the SiC seed crystal to undergo a dislocation movement so that seed screw dislocations recombine.

Abstract: A SiC volume monocrystal is produced by sublimation growth. An SiC seed crystal is placed in a crystal growth region of a growing crucible and SiC source material is introduced into an SiC storage region. During growth, at a growth temperature of up to 2,400° C. and a growth pressure between 0.1 mbar and 100 mbar, an SiC growth gas phase is generated by sublimation of the SiC source material and by transport of the sublimated gaseous components into the crystal growth region, where an SiC volume monocrystal grows by deposition from the SiC growth gas phase on the SiC seed crystal. Prior to the start of growth, the SiC seed crystal is examined at the growth surface for the presence of seed screw dislocations, nucleation centers are generated, wherein the nucleation centers are starting points for at least one compensation screw dislocation during the growth carried out subsequently.

Abstract: A prime mover, such as a tractor, is disclosed. The prime mover includes a drivetrain, a driver assistance system, and a tire pressure control system. The tire pressure control system is equipped with pneumatic components for setting and adapting a tire pressure of at least one of the tires of the prime mover and an attachment to the prime mover. The drivetrain includes at least one drive motor, one gearbox, at least one power take-off, and at least one ancillary unit. The driver assistance system controls the tire pressure control system and includes a computing unit, a memory unit, and an input/output unit. In particular, the driver assistance system includes an automatic tire pressure controller that operates based on a characteristic curve and is configured for optimized control of the tire pressure control system depending on selectable control strategies and/or optimization target variables.

Abstract: A support element fastens an interior lining part to a structural part of a vehicle, wherein the interior lining part is fastenable to the structural part via the support element. The support element has at least one deformation region which is of meandering design in at least one plane and is deformable under the application of a force.

Abstract: The present invention relates to a silicon carbide (SiC) substrate with improved mechanical and electrical characteristics. Furthermore, the invention relates to a method for producing a bulk SiC crystal in a physical vapor transport growth system. The silicon carbide substrate comprises an inner region (102) which constitutes at least 30% of a total surface area of said substrate (100), a ring shaped peripheral region (104) radially surrounding the inner region (102), wherein a mean concentration of a dopant in the inner region (102) differs by at maximum 5·1018 cm?3, preferably 1·1018 cm?3, from the mean concentration of this dopant in the peripheral region (104).

Abstract: A system including circuitry configured to process image data of a meal to obtain information on the contents of the meal; generate, based on the obtained information, a query with guidance to change image capture settings: and guide a user to pick up at least a part of the meal.

Abstract: The present invention relates to a hemostasis band, comprising a band, preferably made from an elastic material, a pressure focusing element for focusing pressure generated by the band to hold a cannula in place at a cannulation point, wherein the band can be arranged in a loop and the size of the loop formed by the band is adjustable to at least one defined size by means of an external tool, such as a torque driver. Another aspect of the invention relates to a system of a hemostasis band and an external tool.

Abstract: The present disclosure relates to a medical treatment system with a reading device programmed for - preferably contactless - gathering of information which serves to identify a healthcare professional and programmed to provide the gathered information to an authorization device. Furthermore, the medical treatment system comprises an apparatus of a group of items consisting of one or more treatment apparatuses for treating a patient, one or more diagnostic apparatuses for examining the patient and one or more further clinic apparatuses, e.g., for the logistical running of the clinic or practice operation. Furthermore, the medical treatment system comprises an authorization device for allowing or prohibiting one or more activities with or on the apparatus from the group and/or one or more movements of the healthcare professional in the vicinity of the apparatus from the group depending on the information provided by the reading device.

Abstract: The present invention relates to a silicon carbide (SiC) substrate with improved mechanical and electrical characteristics. Furthermore, the invention relates to a method for producing a bulk SiC crystal in a physical vapor transport growth system. The silicon carbide substrate comprises an inner region (102) which constitutes at least 30% of a total surface area of said substrate (100), a ring shaped peripheral region (104) radially surrounding the inner region (102), wherein a mean concentration of a dopant in the inner region (102) differs by at least 1·1018 cm?3 from the mean concentration of this dopant in the peripheral region (104).

Abstract: The invention relates to a respiratory air purifier device.

Abstract: The present invention relates to a silicon carbide (SiC) substrate with improved mechanical and electrical characteristics. Furthermore, the invention relates to a method for producing a bulk SiC crystal in a physical vapor transport growth system. The silicon carbide substrate comprises an inner region (102) which constitutes at least 30% of a total surface area of said substrate (100), a ring shaped peripheral region (104) radially surrounding the inner region (102), wherein a mean concentration of a dopant in the inner region (102) differs by at least 1-1018 cm-3 from the mean concentration of this dopant in the peripheral region (104).

Abstract: The present invention relates to a chamfered silicon carbide substrate which is essentially monocrystalline, and to a corresponding method of chamfering a silicon carbide substrate. A silicon carbide substrate according to the invention comprises a main surface (102), wherein an orientation of said main surface (102) is such that a normal vector ({right arrow over (O)}) of the main surface (102) includes a tilt angle with a normal vector ({right arrow over (N)}) of a basal lattice plane (106) of the substrate, and a chamfered peripheral region (110), wherein a surface of the chamfered peripheral region includes a bevel angle with said main surface, wherein said bevel angle is chosen so that, in more than 75% of the peripheral region, normal vectors ({right arrow over (F)}_i) of the chamfered peripheral region (110) differ from the normal vector of the basal lattice plane by less than a difference between the normal vector of the main surface and the normal vector of the basal lattice plane of the substrate.

Abstract: An arrangement for operating a biosensor emitting radiation includes an excitation light source, which generates at least one excitation radiation for the biosensor; a coupling fiber, at the entry surface of which the excitation radiation is coupled in; an optical Y-coupler, including an excitation arm, which is connected to the exit surface of the coupling fiber, a detector arm, which is connected to an optical detector, and a sensor foot, which can be connected to the biosensor. The excitation arm has a conical shape. The radiation axis of the excitation arm includes an angle in the range of 5° to 70° with the main radiation axis of the detector arm. The diameter of the excitation arm at the connecting point to the detector arm is less than two thirds the diameter of the detector arm. An arrangement for determining the glucose content blood is also provided.

Abstract: Two workpieces 30, 40 are joined by means of ultrasound. First, a workpiece 30 with at least one energy direction sensor 31 and a second workpiece 40 are provided. The workpieces are brought into contact with each other in such a way that the energy direction sensor 31 comes into contact with a first surface 41 of the second workpiece 40. Ultrasonic vibrations are then introduced into one of the workpieces 40 via a working surface 11 of a sonotrode 10. A sonotrode 10 is used, which has a contour with contact lines 12 on the working surface 11. The sonotrode 10 is positioned with respect to the first workpiece 30 in such a way that the contact lines 12 run transversely to the energy direction generator 31.

Abstract: The present invention relates to a chamfered silicon carbide substrate which is essentially monocrystalline, and to a corresponding method of chamfering a silicon carbide substrate. A silicon carbide substrate according to the invention comprises a main surface (102), wherein an orientation of said main surface (102) is such that a normal vector ({right arrow over (O)}) of the main surface (102) includes a tilt angle with a normal vector ({right arrow over (N)}) of a basal lattice plane (106) of the substrate, and a chamfered peripheral region (110), wherein a surface of the chamfered peripheral region includes a bevel angle with said main surface, wherein said bevel angle is chosen so that, in more than 75% of the peripheral region, normal vectors ({right arrow over (F)}_i) of the chamfered peripheral region (110) differ from the normal vector of the basal lattice plane by less than a difference between the normal vector of the main surface and the normal vector of the basal lattice plane of the substrate.

Abstract: In accordance with an embodiment, described herein is a system and method for use with a cloud computing environment, for creating or updating tenant artifacts using microservices. A multi-tenant cloud service provides a loosely-coupled and distributed approach for consistently creating or updating tenant artifacts through the use of multiple independent microservice's lifecycle containers, each having their own requirements during the creation or update of a tenant instance. The development and packaging of lifecycle containers is simplified by managing the software code responsible for artifact creation or update within a microservice code repository. The system can use a deployment approach of loosely-coupled microservice lifecycle containers together with an infrastructure lifecycle service that coordinates tenant artifact creation/update across multiple microservices.