Patents by Inventor Ralf Schumacher

Ralf Schumacher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF
    Publication number: 20080132686
    Abstract: Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
    Type: Application
    Filed: October 9, 2007
    Publication date: June 5, 2008
    Inventors: Yvo Graus, Erhard Kopetzki, Klaus-Peter Kuenkele, Olaf Mundigl, Paul Parren, Frank Rebers, Ralf Schumacher, Jan van de Winkel, Martine Vriesema-van Vugt
  • Antibodies against insulin-like growth factor 1 receptor and uses thereof
    Patent number: 7378503
    Abstract: Antibodies which bind to IGF-IR and inhibit the binding of IGF-I and IGF-II to IGF-IR are characterized. These antibodies are implicated in anti-tumor therapy.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: May 27, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yvo Graus, Erhard Kopetzki, Klaus-Peter Kuenkele, Olaf Mundigl, Paul Parren, Frank Rebers, Ralf Schumacher, Jan van de Winkel, Martine Vriesema-van Vugt
  • Electrical apparatus having status indicating means
    Patent number: 7369059
    Abstract: An electrical power distribution device such as a junction box or the like includes a status indicator that also serves not only to indicate the status of energization of a connector mounted in a first housing opening, but also to illuminate a translucent indicia-bearing plate mounted in second housing opening. The housing contains a chamber in which are mounted a light emitting diode that is energized simultaneously with the connector, and a light transmitting member that directs the light produced by the LED toward the second housing opening.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: May 6, 2008
    Assignee: Weidmüller Interface GmbH & Co. KG
    Inventors: Andreas Hoffmann, Andreas Muhs, Hermann Krause, Jürgen Ziemke, Klaus Püschner, Michael Schnatwinkel, Ralf Schumacher, Stefan Reker, Stefan Schumann, Ulrike Klasing
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20080076710
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: May 4, 2007
    Publication date: March 27, 2008
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • Methods for detecting cancer cells by using nucleic acid encoding for IGF-1 receptor interacting proteins
    Patent number: 7348165
    Abstract: The invention relates generally to a method for the detection of the proliferation of a tumor cell and more specifically wherein said method comprises nucleic acids (SEQ ID NO:1) encoding IIP-1.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: March 25, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Tanja Ligensa, Ralf Schumacher, Michael Weidner
  • IGF-1 receptor interacting proteins
    Patent number: 7329734
    Abstract: The invention comprises a nucleic acid molecule with the sequence SEQ ID NO:5 and the complementary sequence, and its use in diagnosis and therapy. This nucleic acid molecule (IIP-10) is a gene which encodes an IGF-1 receptor binding polypeptide.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: February 12, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Tanja Ligensa, Ralf Schumacher, Michael Weidner
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20080031853
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: August 15, 2007
    Publication date: February 7, 2008
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • Antibodies against insulin-like growth factor I receptor and uses thereof
    Publication number: 20080014203
    Abstract: An antibody binding to IGF-IR, being of human IgG1 or IgG3 type and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 98%, and in addition the amount of NGNA is 1% or less and/or the amount of N-terminal alpha-1,3-galactose is 1% or less has improved properties in antitumor therapy.
    Type: Application
    Filed: April 5, 2007
    Publication date: January 17, 2008
    Inventors: Silke Hansen, Klaus-Peter Kuenkele, Dietmar Reusch, Ralf Schumacher
  • Interferon-alpha polypeptides and conjugates
    Patent number: 7318918
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: January 15, 2008
    Assignees: Maxygen, Inc., Roche Palo Alto LLC
    Inventors: Phillip A. Patten, Sridhar Viswanathan, Torben Lauesgaard Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Andreas Schaubmar, Hans Koll
  • Glycosylated antibodies
    Publication number: 20070248600
    Abstract: The invention provides an antibody comprising human IgG1 or IgG3 heavy chain constant domains that are glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is at least 99%, and in addition the amount of NGNA is 1% or less and/or the amount of N-terminal alpha 1,3 galactose is 1% or less, and uses thereof.
    Type: Application
    Filed: April 5, 2007
    Publication date: October 25, 2007
    Inventors: Silke Hansen, Klaus-Peter Kuenkele, Dietmar Reusch, Ralf Schumacher
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20070225205
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: September 14, 2006
    Publication date: September 27, 2007
    Applicants: MAXYGEN, INC., ROCHE PALO ALTO LLC
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20070225204
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: September 14, 2006
    Publication date: September 27, 2007
    Applicants: MAXYGEN, INC., ROCHE PALO ALTO LLC
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • Peptide-immunoglobulin-conjugate
    Publication number: 20070148180
    Abstract: The current invention is related to peptide-immunoglobulin-conjugates in which at least two of the termini of the immunoglobulin polypeptide chains are conjugated to a peptide, whereby the peptides can be different, similar or identical. The conjugation is effected on the nucleic acid level.
    Type: Application
    Filed: October 19, 2006
    Publication date: June 28, 2007
    Inventors: Stephan Fischer, Erhard Kopetzki, Suryanarayana Sankuratri, Ralf Schumacher
  • Electrical connector with quick release means
    Patent number: 7207824
    Abstract: An electrical plug connector arrangement includes a male plug member that is normally locked in engagement with a female socket member by a plurality of radially inwardly directed spring fingers that engage the threads of an externally threaded portion of the plug member, together with an annular quick-release member that is axially displaceable relative to the socket member to release the spring fingers from the threads on the plug member, thereby to permit separation of the plug and socket members.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: April 24, 2007
    Assignee: Weidmuller Interface GmbH & Co. KG
    Inventors: Ralf Schumacher, Jürgen Ziemke
  • ELECTRICAL CONNECTOR WITH QUICK RELEASE MEANS
    Publication number: 20070087613
    Abstract: An electrical plug connector arrangement includes a male plug member that is normally locked in engagement with a female socket member by a plurality of radially inwardly directed spring fingers that engage the threads of an externally threaded portion of the plug member, together with an annular quick-release member that is axially displaceable relative to the socket member to release the spring fingers from the threads on the plug member, thereby to permit separation of the plug and socket members.
    Type: Application
    Filed: September 11, 2006
    Publication date: April 19, 2007
    Inventors: Ralf Schumacher, Jurgen Ziemke
  • IGF-1 receptor interacting proteins
    Patent number: 7202058
    Abstract: The invention comprises a method of screening compound(s) that inhibit the interaction between IGF-1R and IIP-10.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: April 10, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Tanja Ligensa, Ralf Schumacher, Michael Weidner
  • Electrical apparatus having status indicating means
    Publication number: 20070040698
    Abstract: An electrical power distribution device such as a junction box or the like includes a status indicator that also serves not only to indicate the status of energization of a connector mounted in a first housing opening, but also to illuminate a translucent indicia-bearing plate mounted in second housing opening. The housing contains a chamber in which are mounted a light emitting diode that is energized simultaneously with the connector, and a light transmitting member that directs the light produced by the LED toward the second housing opening.
    Type: Application
    Filed: December 2, 2005
    Publication date: February 22, 2007
    Inventors: Andreas Hoffmann, Andreas Muhs, Hermann Krause, Jurgen Ziemke, Klaus Puschner, Michael Schnatwinkel, Ralf Schumacher, Stefan Reker, Stefan Schumann, Ulrike Klasing
  • Antibodies against CCR5 and uses thereof
    Publication number: 20070036796
    Abstract: Antibodies that specifically bind to CCR5 are useful for treating immunosuppressive disease.
    Type: Application
    Filed: March 31, 2006
    Publication date: February 15, 2007
    Inventors: Michael Brandt, Surya Sankuratri, Ralf Schumacher, Stefan Seeber
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20070025966
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: September 13, 2006
    Publication date: February 1, 2007
    Applicants: MAXYGEN, INC., ROCHE PALO ALTO LLC
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20070020734
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: September 13, 2006
    Publication date: January 25, 2007
    Applicants: MAXYGEN, INC., ROCHE PALO ALTO LLC
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski