Abstract: A fuel distributor which has a pressure accumulator rail for receiving pressurized fuel. The pressure accumulator rail has a forged base body. Mounting supports are joined to the base body by substance bonding. A mounting support is formed by two metal brackets each configured as a sheet-metal formed part. Each metal bracket has a holding portion adapted to the outer contour of the base body, a leg angled relative to the holding portion, and a mounting flange on the free end of the leg and angled away therefrom. A length portion of the base body is received between the holding portions. The holding portions partially surround the base body. The base body and the holding portions are joined by substance bonding. The legs of the two metal brackets lie next to each other at least in regions and are also joined together by substance bonding.

Abstract: A fuel distributor which has a pressure accumulator rail for receiving pressurized fuel. The pressure accumulator rail has a forged base body. Mounting supports are joined to the base body by substance bonding. A mounting support is formed by two metal brackets each configured as a sheet-metal formed part. Each metal bracket has a holding portion adapted to the outer contour of the base body, a leg angled relative to the holding portion, and a mounting flange on the free end of the leg and angled away therefrom. A length portion of the base body is received between the holding portions. The holding portions partially surround the base body. The base body and the holding portions are joined by substance bonding. The legs of the two metal brackets lie next to each other at least in regions and are also joined together by substance bonding.

Abstract: A sheet-fed, rotary, printing press for printing on both sides of sheets without a sheet reversing device, includes printing units having a modular construction. Each module includes at least a plate cylinder, a blanket cylinder, an impression cylinder, a transfer cylinder and at least one drive wheel. Modules for printing on the first side of the sheets and modules for printing on the second side of the sheets have an identical construction and are disposed in such a way that one is rotated through 180° relative to the other about an axis extending in a sheet processing direction.

Abstract: A sheet-fed, rotary, printing press for printing on both sides of sheets without a sheet reversing device, includes printing units having a modular construction. Each module includes at least a plate cylinder, a blanket cylinder, an impression cylinder, a transfer cylinder and at least one drive wheel. Modules for printing on the first side of the sheets and modules for printing on the second side of the sheets have an identical construction and are disposed in such a way that one is rotated through 180° relative to the other about an axis extending in a sheet processing direction.

Abstract: The invention provides a human GPR39 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR39 as well as pharmaceutical compositions comprising such compounds.

Abstract: The invention provides a human PRSC1 which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSC1 as well as pharmaceutical compositions comprising such compounds.

Abstract: The invention provides a human NPEPPS which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, muscle-skeleton diseases, neurological diseases, respiratory diseases, inflammation and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, muscle-skeleton diseases, neurological diseases, respiratory diseases, inflammation and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NPEPPS as well as pharmaceutical compositions comprising such compounds.