Abstract: The clamping device is provided for tools and has a coupling piece that is provided with at least one actuating unit. The coupling piece acts to actuate a nut seated on a spindle journal that is receiving the tool. A torque coupling is provided for the nut. The coupling piece is fixedly connected with an output shaft that is in drive connection with a drive shaft by a transmission gear. As a result of the transmission gear, it is possible to rotate the drive shaft with minimal moment in order to apply the great clamping force required for axial clamping of the tool.

Abstract: An electrolyte for a lithium-ion battery which includes lithium hexafluorophosphate and lithium 2-pentafluoroethoxy-1,1,2,2-tetrafluoroethanesulfonate. A lithium-ion battery which includes an electrolyte containing lithium hexafluorophosphate and lithium 2-pentafluoroethoxy-1,1,2,2-tetrafluoroethanesulfonate. A motor vehicle which uses a lithium-ion battery having electrolytes containing lithium hexafluorophosphate and lithium 2-pentafluoroethoxy-1,1,2,2-tetrafluoroethanesulfonate. The electrolyte can increase the service life of the lithium-ion battery.

Abstract: An alkali metal-based energy storage system, having at least one composite electrode containing an active material, and an electrolyte containing a lithium salt dissolved in an aprotic organic solvent, an ionic fluid and/or a polymer matrix. The electrolyte further contains an additive selected from a cation or a compound of a metal selected from Mg, Al, Cu and/or Cr. The metal selected from Mg, Al, Cu and/or Cr is applied onto the active material and/or the active material of the composite electrode is partially replaced by the metal selected from Mg, Al, Cu and/or Cr in the form of a metal powder or a metal salt.

Abstract: A pressing device for a machine tool for processing or machining workpieces made of wood or plastics is provided with at least one support with a counter wedge surface. At least one pressing element is fastened to the at least one support. At least one wedge clamping device is provided that has at least one wedge pressure member with a first wedge surface that is resting on the counter wedge surface of the at least one support. The at least one wedge clamping device also has at least one adjusting element acting on the at least one wedge pressure member. The at least one wedge clamping device clamps the at least one pressing element on the at least one support. A machine tool with such a pressing device is provided.

Abstract: A belt pulley arrangement for a belt drive for driving auxiliary units of a motor vehicle, comprising a belt pulley for introducing a torque that can be supplied by a traction mechanism, an output shaft for driving an auxiliary unit, particularly a coolant pump, an electric machine for transmitting torque between the belt pulley and the output shaft, the electric machine including a rotor connected to the belt pulley and a stator connected to the output shaft, and being able to be electrically connected to an electric energy source for the purpose of accelerating the output shaft and/or to an electric energy sink in order to decelerate the output shaft, a first rotational speed measurement device for detecting the time curve of the rotational speed of the belt pulley and/or a second rotational speed measurement device for detecting the time curve of the rotational speed of the output shaft, and a control device connected to the electric energy source and/or electric energy sink so as to control an output shaf

Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.

Abstract: A precipitation detector, a single actuation of a switch or the departure of a drive triggers operation of a motor to close a window, sun roof or convertible top. In order to prevent injury to a person who might be nearby the vehicle when the motor operates, humanoid detectors monitor the area around a vehicle and detect whether a person is nearby and who could thus be injured by a computer-controlled operation of the window, sun roof or top. The operation of a power window, sun roof or convertible top is stopped or inhibited when a person is detected near the vehicle in order to prevent the person from being injured by the closure of with window, sun roof or top.

Abstract: In monitoring the machine space of a processing machine during the throughput of workpieces in order to detect workpieces that got stuck, the rear end of a workpiece with reference to the transport direction generates a start signal in the inlet region of the machine space, as well as an end signal in the outlet region thereof by sensors that are connected to a control unit. Beginning with the start signal, the control unit detects a feature that characterizes a theoretical feed travel and generates a release signal if the value of the detected characteristic feature has reached at the time, at which the end signal is generated, a predefined limiting value and not yet exceeded a predefined upper limiting value or if the end signal is generated at a time, at which the value of the detected characteristic feature has reached the predefined limiting value and not yet exceeded the upper limiting value.

Abstract: The adjusting device for a pressure roller of a processing machine has a pivotable support arm carrying a pressure roller adjustable with the support arm from a pressure position into a resting position. The support arm is seated on a support rod that engages a clamping aperture of a pressure roller bracket. The support rod has a first section with noncircular cross section that forms a form-fit section cooperating with the clamping aperture of the pressure roller bracket by form-fit. The support rod has a second section arranged axially offset to the first section and forming a rotary section. It rests against the inner side of the clamping aperture and allows rotation of the support rod about its axis in the clamping aperture. The pressure roller can be pivoted easily into a resting position and/or transverse to the workpiece in the width direction with a constructively simple design.

Abstract: A clamping device for an adjustable stop of a processing machine for guiding workpieces through the processing machine is provided with at least one clamping part that clamps the stop against at least one counter stop. The clamping part is provided on a transmission element, wherein the transmission element is acted upon with a force (F1) that is converted into a clamping force (F2) acting upon the clamping part. A release unit is provided for releasing the clamping action. The transmission element is a two-armed lever, one arm of which is acted upon with the force (F1) in the form of a compressive force and the other arm of which generates the clamping force (F2).

Abstract: A belt pulley arrangement for a belt drive to drive auxiliary units of a motor vehicle, having a belt pulley for introducing a torque that can be provided via a flexible drive means, an output shaft for driving an auxiliary unit, in particular a cooling water pump, and an electric machine for the transmission of torque between the belt pulley and the output shaft, wherein the electric machine has a rotor connected to the belt pulley and a stator connected to the output shaft. As a result of the power flow between the belt pulley and the output shaft, which can be influenced by the electric machine, it is not necessary to design the auxiliary unit that is attached via the output shaft for the least beneficial operating point, so that the auxiliary unit can be dimensioned smaller and a reduction in the installation space for motor vehicle components, in particular the installation space for auxiliary units of a motor vehicle that can be driven via the belt drive, is made possible.

Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.

Abstract: A roller device for a traction mechanism drive, with a roller element for introducing a torque provided via the traction mechanism and a driven shaft for driving an auxiliary unit of a motor vehicle. The roller device further has a magnetic coupling for torque transfer between the roller element and the driven shaft. The magnetic coupling has a primary-side unit connected to the roller element having a primary magnetic element and a secondary-side unit connected to the driven shaft with a secondary-side magnetic element. The magnetic elements are permanent and/or electromagnetic elements and the torque transfer is realized by magnetic fields of the primary and secondary-side magnetic elements. At least one magnetic element of the two units for changing the magnetic field overlap of the magnetic fields of the primary and secondary-side magnetic elements is arranged movably within its unit by the centrifugal forces occurring during operation.

Abstract: A roller device for a traction mechanism drive of a motor vehicle, with a roller element for introducing a torque provided via the traction mechanism and a driven shaft for driving an auxiliary unit. The roller device has a magnetic coupling for non-positive torque transfer between the roller element and the driven shaft. The magnetic coupling has a primary-side unit connected to the roller element with a primary magnetic element and a secondary-side unit connected to the driven shaft with a secondary-side magnetic element. The magnetic elements are permanent and/or electromagnetic elements. The non-positive torque transfer is realized by magnetic fields of the primary-side and secondary-side magnetic elements. At least one magnetic element of the two units for changing the magnetic field overlap of the magnetic fields of the primary-side and secondary-side magnetic elements is movably arranged within its unit. A corresponding traction mechanism drive and method are provided.

Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.

Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.

Abstract: The invention relates to vector constructs for an HIV-specific gene therapy. The expression of transgenes is coupled with an infection of the cell with HIV while the transcription of the transgene is controlled by a transcription control region derived from HIV. In addition, the transgene is improved with regard to RNA stability and expression efficiency by modifying the nucleotide sequence.

Abstract: The present invention relates to synthetic gag and gagpol genes optimized for high level expression via codon optimization and the uses thereof for the efficient generation of vector particles. The invention further relates to the generation of packaging cells and vaccines based on the synthetic gag and gagpol genes.

Abstract: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps. The invention additionally relates to a device for carrying out this method.