Patents by Inventor Ralph Baric

Ralph Baric has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR MATURE DENGUE VIRUSES AS VACCINES AND DIAGNOSTICS
    Publication number: 20240156941
    Abstract: This invention relates to mature flavivirus particles and methods of making and using the same. This invention further relates to flavivirus prM glycoproteins, nucleic acids encoding the same, as well as particles, populations, and compositions comprising the same. Also disclosed are methods of making and using the prM glycoproteins of the invention.
    Type: Application
    Filed: March 17, 2022
    Publication date: May 16, 2024
    Inventors: Ralph Baric, Long Ping Victor Tse, Rita Meganck
  • STABILIZED NOROVIRUS VIRUS-LIKE PARTICLES AS VACCINE IMMUNOGENS
    Publication number: 20230381293
    Abstract: Recombinant Norovirus Virus-Like Particles (VLPs) formed from recombinant Norovirus VP1 proteins, and methods of their use and production are disclosed. In several embodiments, the Recombinant Norovirus VLPs can be used to generate an immune response to Norovirus VP1 protein in a subject. In additional embodiments, an effective amount of the recombinant Norovirus VLPs can be administered to a subject in a method of inhibiting a Norovirus infection.
    Type: Application
    Filed: October 14, 2021
    Publication date: November 30, 2023
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The University of North Carolina at Chapel Hill, Board of Regents, the University of Texas System
    Inventors: Peter Kwong, Raffaello Verardi, Yaroslav Tsybovsky, Jason Gorman, Gwo-Yu Chuang, Li Ou, Lisa Lindesmith, Ralph Baric, George Georgiou, Inga Rimkute, Mario Roederer
  • METHODS AND COMPOSITIONS FOR TREATMENT OF CORONAVIRUS INFECTION
    Publication number: 20230137667
    Abstract: The present invention provides methods and compositions for treating coronavirus infection and diseases and disorders associated with or caused by coronavirus infection.
    Type: Application
    Filed: March 19, 2021
    Publication date: May 4, 2023
    Inventors: Ralph Baric, Amy Sims, Hugh D. Mitchell, Katrina M. Waters
  • HUMAN ANTI-DENGUE ANTIBODIES AND METHODS OF USE THEREFOR
    Publication number: 20230078330
    Abstract: The present disclosure is directed to antibodies binding to and neutralizing dengue virus and methods for use thereof.
    Type: Application
    Filed: January 19, 2021
    Publication date: March 16, 2023
    Inventors: James E. CROWE, JR., Ralph BARIC, Eva HARRIS
  • METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES OR VACCINE AND DIAGNOSTIC DEVELOPMENT
    Publication number: 20230018080
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that may introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: November 20, 2020
    Publication date: January 19, 2023
    Inventors: Ralph Baric, Ellen Young, Jennifer Munt
  • SARS-CoV-2 viruses and methods of use thereof
    Patent number: 11492379
    Abstract: This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: November 8, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Harold Kenneth Dinnon, III, Sarah Rebecca Leist, Yixuan Hou
  • SARS-COV-2 VIRUSES AND METHODS OF USE THEREOF
    Publication number: 20220135625
    Abstract: This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof.
    Type: Application
    Filed: December 20, 2021
    Publication date: May 5, 2022
    Inventors: Ralph Baric, Harold Kenneth Dinnon, III, Sarah Rebecca Leist, Yixuan Hou
  • Methods and compositions for dengue virus serotype 4 epitopes
    Patent number: 11241491
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: February 8, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Matthew Begley, Douglas Widman, Aravinda Desilva, Usha Nivarthi, Boyd Yount, Ellen Young
  • Mouse-adapted SARS-CoV-2 viruses and methods of use thereof
    Patent number: 11225508
    Abstract: This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: January 18, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Kenneth Harold Dinnon, III, Sarah Rebecca Leist
  • Methods and compositions for dengue virus vaccines
    Patent number: 10870682
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: December 22, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT
    Publication number: 20200230224
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: August 29, 2019
    Publication date: July 23, 2020
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom
  • METHODS AND COMPOSITIONS FOR DENGUE VIRUS SEROTYPE 4 EPITOPES
    Publication number: 20200155663
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: May 23, 2018
    Publication date: May 21, 2020
    Inventors: Ralph BARIC, Matthew BEGLEY, Douglas WIDMAN, Aravinda DESILVA, Usha NIVARTHI, Boyd YOUNT, Ellen YOUNG
  • Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development
    Patent number: 10398768
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: September 3, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom
  • METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES
    Publication number: 20190225654
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: August 20, 2018
    Publication date: July 25, 2019
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • METHODS AND COMPOSITIONS FOR ZIKA VIRUS VACCINES
    Publication number: 20190023745
    Abstract: The present invention methods and compositions for treating a Zika virus infection in a subject, comprising administering to the subject an effective amount of an antibody against Zika virus and/or an epitope that induces an immune response to Zika virus.
    Type: Application
    Filed: July 19, 2018
    Publication date: January 24, 2019
    Inventors: Ralph Baric, Jessica A. Plante, Jesica Swanstrom, Matthew Begley
  • Methods and compositions for dengue virus vaccines
    Patent number: 10053493
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: August 21, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • Methods and compositions for chimeric coronavirus spike proteins
    Patent number: 9884895
    Abstract: The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: February 6, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Sudhakar Agnihothram, Boyd Yount
  • METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT
    Publication number: 20170333548
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: November 2, 2015
    Publication date: November 23, 2017
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom
  • METHODS AND COMPOSITIONS FOR CHIMERIC CORONAVIRUS SPIKE PROTEINS
    Publication number: 20170096455
    Abstract: The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.
    Type: Application
    Filed: March 20, 2015
    Publication date: April 6, 2017
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Sudhakar Agnihothram, Boyd Yount
  • Methods and Compositions for Dengue Virus Vaccines
    Publication number: 20160257719
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: June 26, 2014
    Publication date: September 8, 2016
    Inventors: William MESSER, Ralph BARIC, Aravinda DE SILVA, Boyd YOUNT