Patents by Inventor Ralph O. SCHOENLEBER

Ralph O. SCHOENLEBER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MANUFACTURE OF DISULFIDE BONDED PEPTIDES
    Publication number: 20220213139
    Abstract: A method and apparatus for the manufacture of disulfide bonded peptides is provided, wherein a solution of an oxidizing agent and a solution of a peptide comprising at least two sulfhydryl groups are added simultaneously into a reaction vessel under such conditions that the average concentration of the oxidizing agent inside the reaction vessel is essentially zero during simultaneous addition.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 7, 2022
    Inventors: Ralf EISENHUTH, Daniel SAMSON, Ralph O. SCHOENLEBER, Patrizia MARCHETTI
  • Solid phase synthesis of acylated peptides
    Patent number: 11186608
    Abstract: The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: November 30, 2021
    Assignee: Bachem Holding AG
    Inventors: Ralph O. Schoenleber, Guenther Loidl
  • Method for preparing glucagon-like peptides
    Patent number: 11117946
    Abstract: The present invention refers to a method for preparing a glucagon-like peptide, comprising precipitation of the peptide or of a precursor peptide by means of mixing with an anti-solvent comprising diisopropyl ether and acetonitrile. Further, the present invention also relates to a peptide conjugated to a solid phase and a pharmaceutical composition comprising a Liraglutide peptide obtainable from a method according to the present invention.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: September 14, 2021
    Inventors: Guenther Loidl, Benjamin Neuhaus, Ralph O. Schoenleber, Andreas Stadelmaier
  • MANUFACTURE OF GLUCAGON PEPTIDES
    Publication number: 20210122782
    Abstract: The present invention refers to a method of purifying a glucagon peptide, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at using a mobile phase comprising a triethylammonium phosphate (TEAP) buffer and acetonitrile, and the second step is carried out at using a mobile phase comprising aqueous acetic acid and acetonitrile.
    Type: Application
    Filed: January 30, 2019
    Publication date: April 29, 2021
    Inventors: Ralf EISENHUTH, Guenther LOIDL, Daniel SAMSON, Ralph O. SCHOENLEBER
  • SOLID PHASE SYNTHESIS OF ACYLATED PEPTIDES
    Publication number: 20210009631
    Abstract: The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.
    Type: Application
    Filed: July 10, 2018
    Publication date: January 14, 2021
    Applicant: Bachem Holding AG
    Inventors: Ralph O. SCHÖNLEBER, Günther LOIDL
  • PURIFICATION OF GLUCAGON-LIKE PEPTIDE 1 ANALOGS
    Publication number: 20200371069
    Abstract: The present invention refers to a method of purifying a glucagon-like peptide 1 analogs, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at a pH value between 7.0 to 7.8 using a mobile phase comprising a phosphate buffer and acetonitrile, and the second step is carried out at a pH value below 3.0 using a mobile phase comprising trifluoroacetic acid and acetonitrile.
    Type: Application
    Filed: June 5, 2020
    Publication date: November 26, 2020
    Applicant: BACHEM HOLDING AG
    Inventors: Andreas STADELMAIER, Ralph O. SCHOENLEBER, Daniel SAMSON, Frank DETTNER
  • Purification of glucagon-like peptide 1 analogs
    Patent number: 10690635
    Abstract: The present invention refers to a method of purifying a glucagon-like peptide 1 analogs, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at a pH value between 7.0 to 7.8 using a mobile phase comprising a phosphate buffer and acetonitrile, and the second step is carried out at a pH value below 3.0 using a mobile phase comprising trifluoroacetic acid and acetonitrile.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: June 23, 2020
    Assignee: BACHEM HOLDING AG
    Inventors: Andreas Stadelmaier, Ralph O. Schoenleber, Daniel Samson, Frank Dettner
  • PURIFICATION OF GLUCAGON-LIKE PEPTIDE 1 ANALOGS
    Publication number: 20190113483
    Abstract: The present invention refers to a method of purifying a glucagon-like peptide 1 analogs, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at a pH value between 7.0 to 7.8 using a mobile phase comprising a phosphate buffer and acetonitrile, and the second step is carried out at a pH value below 3.0 using a mobile phase comprising trifluoroacetic acid and acetonitrile.
    Type: Application
    Filed: March 21, 2017
    Publication date: April 18, 2019
    Applicant: BACHEM HOLDING AG
    Inventors: Andreas STADELMAIER, Ralph O. SCHOENLEBER, Daniel SAMSON, Frank DETTNER
  • METHOD FOR PREPARING GLUCAGON-LIKE PEPTIDES
    Publication number: 20190100569
    Abstract: The present invention refers to a method for preparing a glucagon-like peptide, comprising precipitation of the peptide or of a precursor peptide by means of mixing with an anti-solvent comprising diisopropyl ether and acetonitrile. Further, the present invention also relates to a peptide conjugated to a solid phase and a pharmaceutical composition comprising a Liraglutide peptide obtainable from a method according to the present invention.
    Type: Application
    Filed: March 21, 2017
    Publication date: April 4, 2019
    Inventors: Guenther LOIDL, Benjamin NEUHAUS, Ralph O. SCHOENLEBER, Andreas STADELMAIER