Patents by Inventor Ralph Yamamoto

Ralph Yamamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of manufacturing amino acid compositions
    Patent number: 11679089
    Abstract: This disclosure provides methods of manufacturing large-scale blended preparations comprising one or more amino acids wherein the preparations have certain properties.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: June 20, 2023
    Assignee: AXCELLA HEALTH INC.
    Inventors: Thomas Hanlon, Ralph Yamamoto, Denise K. Kwok, Daniel Rothenberg, Andrew M. Wood
  • REDUCED VOLUME FORMULATIONS INCLUDING AMINO ACID ENTITIES
    Publication number: 20210128466
    Abstract: This disclosure provides compositions and methods for improving the dispersion of a hydrophobic amino acid entity in an aqueous suspension. This disclosure further provides compositions and methods for improving the stability of N-acetylcysteine in the presence of acetyl acceptors, e.g., carnitine.
    Type: Application
    Filed: October 9, 2020
    Publication date: May 6, 2021
    Inventors: Jason Legassie, Thomas Hanlon, Ralph Yamamoto, Daniel Rothenberg, Weijia Niu, Benjamin Farina
  • METHODS OF MANUFACTURING AMINO ACID COMPOSITIONS
    Publication number: 20190388374
    Abstract: This disclosure provides methods of manufacturing large-scale blended preparations comprising one or more amino acids wherein the preparations have certain properties.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 26, 2019
    Inventors: Thomas Hanlon, Ralph Yamamoto, Denise K. Kwok, Daniel Rothenberg, Andrew M. Wood
  • PCR assay for animal origin of heparin
    Patent number: 9758819
    Abstract: The invention provides methods and reagents for use in distinguishing heparin sodium of porcine origin from heparin sodium of bovine origin using quantitative polymerase chain reaction.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: September 12, 2017
    Assignee: NantPharma, LLC
    Inventors: Ralph Yamamoto, Enrico Giuseppe Bellomo
  • PCR ASSAY FOR ANIMAL ORIGIN OF HEPARIN
    Publication number: 20150267252
    Abstract: The invention provides methods and reagents for use in distinguishing heparin sodium of porcine origin from heparin sodium of bovine origin using quantitative polymerase chain reaction.
    Type: Application
    Filed: October 12, 2012
    Publication date: September 24, 2015
    Inventors: Ralph YAMAMOTO, Enrico Giuseppe BELLOMO
  • Method of measuring the concentration of a glycosaminoglycan anticoagulant
    Patent number: 8273580
    Abstract: The invention provides an accurate, economical, automatable, high throughput method for the determination of the concentration of glycosaminoglycan anticoagulants, including low molecular weight heparin (LMWH) anticoagulants, in aqueous solutions. A method for cleaning a unit of manufacturing equipment used in the preparation of a LMWH to obtain an acceptable residual concentration of LMWH is further provided.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: September 25, 2012
    Assignee: Active BioMaterials, LLC
    Inventors: Ralph Yamamoto, Yumi Kim
  • METHOD OF MEASURING THE CONCENTRATION OF A GLYCOSAMINOGLYCAN ANTICOAGULANT
    Publication number: 20120009686
    Abstract: The invention provides an accurate, economical, automatable, high throughput method for the determination of the concentration of glycosaminoglycan anticoagulants, including low molecular weight heparin (LMWH) anticoagulants, in aqueous solutions. A method for cleaning a unit of manufacturing equipment used in the preparation of a LMWH to obtain an acceptable residual concentration of LMWH is further provided.
    Type: Application
    Filed: July 5, 2011
    Publication date: January 12, 2012
    Inventors: Ralph YAMAMOTO, Yumi Kim
  • Method for measuring the concentration of a glycosaminoglycan anticoagulant
    Patent number: 8003402
    Abstract: The invention provides an accurate, economical, automatable, high throughput method for the determination of the concentration of glycosaminoglycan anticoagulants, including low molecular weight heparin (LMWH) anticoagulants, in aqueous solutions. A method for cleaning a unit of manufacturing equipment used in the preparation of a LMWH to obtain an acceptable residual concentration of LMWH is further provided.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: August 23, 2011
    Assignee: Active BioMaterials, LLC
    Inventors: Ralph Yamamoto, Yumi Kim
  • METHOD FOR MEASURING THE CONCENTRATION OF A GLYCOSAMINOGLYCAN ANTICOAGULANT
    Publication number: 20090042303
    Abstract: The invention provides an accurate, economical, automatable, high throughput method for the determination of the concentration of glycosaminoglycan anticoagulants, including low molecular weight heparin (LMWH) anticoagulants, in aqueous solutions. A method for cleaning a unit of manufacturing equipment used in the preparation of a LMWH to obtain an acceptable residual concentration of LMWH is further provided.
    Type: Application
    Filed: July 24, 2008
    Publication date: February 12, 2009
    Applicant: ABRAXIS BIOSCIENCE, INC.
    Inventor: Ralph YAMAMOTO
  • Identification of M-CSF agonists and antagonists
    Patent number: 6025146
    Abstract: The present invention is directed to methods for crystallizing macrophage colony stimulating factor. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 15, 2000
    Assignee: Chiron Corporation
    Inventors: Jayvardhan Pandit, Jarmila Jancarik, Sung-Hou Kim, Kirston Koths, Robert Halenbeck, Anna Lisa Fear, Eric Taylor, Ralph Yamamoto, Andrew Bohm
  • Crystallization of M-CSF.alpha.
    Patent number: 5866114
    Abstract: The present invention is directed to methods for crystallizing macrophage colony stimulating factor (M-CSF) and to a crystalline M-CSF produced thereby. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: February 2, 1999
    Assignee: Chiron Corporation
    Inventors: Jayvardhan Pandit, Jarmila Jancarik, Sung-Hou Kim, Kirston Koths, Robert Halenbeck, Anna Lisa Fear, Eric Taylor, Ralph Yamamoto, Andrew Bohm
  • Purification method for tumor necrosis factor
    Patent number: 4677197
    Abstract: An improved method for purifying TNF, especially recombinantly produced TNF in bacteria, is disclosed. The purification employs a hydrophobic support in a chromatographic column which is then developed, preferably by HPLC. Preliminary purifications using anion exchange resins are also helpful.
    Type: Grant
    Filed: October 30, 1985
    Date of Patent: June 30, 1987
    Assignee: Cetus Corporation
    Inventors: Leo S. Lin, Ralph Yamamoto