Abstract: Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

Abstract: Described are devices, methods, and systems for achieving occlusion of vascular vessels. Further described are certain reduced or low profile procedures and devices for the percutaneous occlusion of the saphenous vein, such as in the treatment of a varicose vein condition caused by venous reflux.

Abstract: A device and system for closure of an opening formed in a body vessel includes a bioabsorbable grasping member and locking member. The grasping member includes grasping lingers that are radially collapsible to the closed positions by movement of the locking member over the fingers. A distal portion of the fingers is configured to grasp an outer wall portion of the body vessel surrounding the opening when the fingers are in the open position. Movement of the locking member can cause the fingers to at least substantially close the vessel opening. Structural features on the fingers and/or locking member can inhibit proximal or distal movement of the locking member when in a locking position. A detachable arm can be coupled to the grasping member to facilitate placement of the grasping member. A sheath can fit over the detachable arm and be configured to move the locking member over the fingers.

Abstract: A hemostatic valve assembly is disclosed. The assembly comprises a housing having a sidewall that tapers radially inwardly towards the housing distal end. A valve member having an open proximal end and a tapered distal end with an orifice formed therein is disposed within the housing chamber. The valve member is deformable between a closed configuration in which the orifice is substantially closed and an open configuration in which the orifice is open. A biasing member disposed proximal to the valve member is moveable between a longitudinally compressed condition and a longitudinally expanded condition. When in an expanded condition, the biasing member pushes the valve member longitudinally and against the tapered sidewall of the housing. The tapered sidewall of the housing urges the distal end of the valve member radially inwardly, thus urging the orifice to the substantially closed configuration.

Abstract: A catheter is provided with a collection chamber located between a seal and a cap. The seal is located distal from the collection chamber, and the cap is located proximal from the collection chamber. The seal may be opened and closed to alternately allow the passage of material into the collection chamber and prevent fluid from escaping from the shaft lumen. The cap may be opened and closed to allow the removal of a mass from the collection chamber and to prevent fluid from escaping during collection of the mass.

Abstract: A cutting tool is provided for cutting the end of a catheter to provide custom length catheters. The cutting tool has a cutting member that moves within the cutting passageway in the housing. The catheter is positioned within a catheter passageway in the housing. The cutting passageway transacts the catheter passageway so that a blade on the cutting member crosses the catheter passageway and cuts through the width of the catheter to form a cut end on the catheter.

Abstract: Medical devices, as well as methods of treatment and manufacturing such devices, are provided for applying vascular therapy locally within the body vessel. The medical devices include an expandable tubular frame and a sleeve or graft material. The medical devices can be used for local delivery of a therapeutic agent within a body vessel or a tamponade for a lacerated body vessel, while simultaneously allowing perfusion of fluid or blood flow distal of the implanted medical device. The tubular frame of the medical device may have a proximal non-expanding portion and a distal self-expanding support structure. The self-expanding support structure can expand radially outward to urge the graft material to contact the wall of the body vessel. In the expanded configuration, a portion of the device allows fluid flow to continue while the sleeve is against the body vessel wall.

Abstract: Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

Abstract: A perfusion device and a delivery system for repair of a damaged portion of a body vessel. Perfusion device can include a tubular body that is self-expandable, having a proximal portion, a distal portion, and an intermediate portion. One or more series of barbs can be disposed circumferentially along the intermediate portion. Barbs are capable of penetrating into the tunica intima and tunica media of said vessel wall upon insertion of said device into said body vessel, and not into said tunica adventitia. A graft can be associated with the tubular body. Graft has a proximal end and a distal end, and preferably extends entirely along a luminal wall of the tubular body. Graft may also extend along an exterior surface of the tubular body at the proximal and distal portions. A remodelable covering can be applied along the intermediate portion. Delivery devices for the perfusion implant and methods of delivering the perfusion implant are also provided.

Abstract: A device for closure of an opening formed in a body vessel includes a grasping member and a sheath movable thereover. The grasping member comprises a tubular body having a plurality of grasping fingers extending from a distal end of the tubular body. The fingers radially extend from the tubular body at a first angle, and are collapsible therefrom to a second angle. The fingers have a distal tip configured for grasping an outer wall of the body vessel surrounding the vessel opening when the fingers are at the first angle. The sheath is slidable over the tubular body and at least a portion of the grasping fingers for collapsing the fingers from the first angle to the second angle, thereby causing the collapsed fingers to at least substantially close the opening.

Abstract: An occluding device is provided for occluding fluid flow through a lumen of a body vessel. The occluding device includes an expandable tubular body having a tubular wall defining a lumen formed therethrough. The tubular wall has a proximal end extending to a distal end along a longitudinal axis of the tubular body. A plurality of longitudinal slits is formed through the tubular wall to define a plurality of flexible strips bound by a proximal non-slit portion and a distal non-slit portion. A plurality of barbs is disposed on the flexible strips. The tubular body is configured to open radially to engage the barbs with the vessel wall defining an expanded state and to collapse along the longitudinal axis to draw the vessel wall radially inward defining a collapsed state. Occluding material is housed within the lumen of the tubular body and the occluding material is configured to move between a collapsed state and an expanded state with the tubular body.

Abstract: A dilator may include a leading portion that includes a leading end coupled to a leading stem. The dilator may further include a trailing portion that includes a trailing end coupled to a trailing shaft. The dilator may also include a segmented body disposed between the leading end and the trailing end. The segmented body may include a plurality of segments disposed circumferentially around the leading stem. The leading stem may extend through a passageway of the segmented body, an opening of the trailing end and a channel of the trailing shaft. The leading stem and the trailing shaft may be configured to move longitudinally relative to one another to radially outwardly expand the segmented body.

Abstract: A valve prosthesis, such as an artificial venous valve, is described. The valve prosthesis has a support frame formed from a cannula and an attached covering that defines an opening adapted to move between a first position in which the opening is open to fluid flow and a second position in which the opening is closed to fluid flow. The support frame includes a leaflet support portion and a circumferential centering support element disposed adjacent the leaflet support portion with respect to a lengthwise axis of the support frame and mirroring the leaflet support portion with respect to a transverse axis of the support frame.

Abstract: The present disclosure provides, in certain aspects, unique products and methods for abrading or otherwise disrupting an interior surface of a bodily a vessel. In some forms, these products and methods further incorporate the use of one or more occluding members to be deployed in the bodily vessel in and/or around a disrupted vessel region. Abrasive endoluminal devices, in certain embodiments, exhibit a low-profile first condition for delivery into and/or through the vasculature. The device can then be transitioned to a second, expanded condition inside the vasculature for carrying out a desired abrasion. With these types of devices, the manner and design by which the device transitions from a first condition to a second condition can vary. Embodiments of such are disclosed herein.

Abstract: An occluding device is provided for occluding fluid flow through a lumen of a body vessel. The occluding device includes an expandable tubular body having a tubular wall defining a lumen formed therethrough. The tubular wall has a proximal end extending to a distal end along a longitudinal axis of the tubular body. A plurality of longitudinal slits is formed through the tubular wall to define a plurality of flexible strips bound by a proximal non-slit portion and a distal non-slit portion. A plurality of barbs is disposed on the flexible strips. The tubular body is configured to open radially to engage the barbs with the vessel wall defining an expanded state and to collapse along the longitudinal axis to draw the vessel wall radially inward defining a collapsed state. Occluding material is housed within the lumen of the tubular body and the occluding material is configured to move between a collapsed state and an expanded state with the tubular body.

Abstract: An occluding device is provided for occluding fluid flow through a lumen of a body vessel. The occluding device includes an expandable tubular body having a tubular wall defining a lumen formed therethrough. The tubular wall has a proximal end extending to a distal end along a longitudinal axis of the tubular body. A plurality of longitudinal slits is formed through the tubular wall to define a plurality of flexible strips bound by a proximal non-slit portion and a distal non-slit portion. A plurality of barbs is disposed on the flexible strips. The tubular body is configured to open radially to engage the barbs with the vessel wall defining an expanded state and to collapse along the longitudinal axis to draw the vessel wall radially inward defining a collapsed state. Occluding material is housed within the lumen of the tubular body and the occluding material is configured to move between a collapsed state and an expanded state with the tubular body.

Abstract: Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

Abstract: Disclosed is an apparatus and system that includes an elongated body, a vascular closure device that can occlude a hole in a vessel wall coupled to a distal end of the elongated body, a sleeve assembly and a biasing member arranged to elastically deform coupled between the elongated body and the sleeve assembly, where the elongated body is longitudinally displaceable with respect to the sleeve assembly, wherein the biasing member exerts a force on the elongated body approximately proportional to a longitudinal displacement between the elongated body and the sleeve assembly and where the biasing member is arranged deform a discernible amount when a conforming force sufficient to occlude the hole is applied to the elongated body through the biasing member and the sleeve assembly.

Abstract: Among other things, methods and apparatus for inserting devices for closing tissue openings are disclosed. Examples may include a handle, sheath and/or sleeve for insertion into a patient and through or adjacent a tissue defect, fistula, or other tissue opening to be closed. Winding mechanisms for operation in or with such inserting devices are also described.

Abstract: Systems and methods for sealing an opening in a wall within the body of a patient are disclosed. In one embodiment, the system has an elongated body coupled to a vascular closure device and a resisting member, the elongated body having a high resistance portion and a low resistance portion and being constructed and arranged to interface with a resisting member to apply a conforming force to a vascular closure device. In some exemplary embodiments, the elongated body comprises a large diameter portion positioned in a proximal end region of the elongated body. Methods and other embodiments are disclosed.