Abstract: Antibodies having modified constant regions so as to permit conjugation of the antibody to a payload such as a therapeutic agent are described. Preferred antibodies include a mutation at light chain position 180 (positional numbering), most preferably the mutation is to a residue selected from C, K, Q, or a non-natural amino acid. Additional mutations may also be combined with a mutation at position 180; including one or more of light chain (LC) S208, LC S171, LC S182, LC A184, LC V191, LC S202, LC S203, LC T206, heavy chain (HC) S160, HC T190, HC S443, HC S447, HC S139, HC S168, HC V170, HC V176, HC T200, HC S445 according to a positional numbering convention.

Abstract: Antibodies having modified constant regions so as to permit conjugation of the antibody to a payload such as a therapeutic agent are described. Preferred antibodies include a mutation at light chain position 180 (positional numbering), most preferably the mutation is to a residue selected from C, K, Q, or a non-natural amino acid. Additional mutations may also be combined with a mutation at position 180; including one or more of light chain (LC) S208, LC S171, LC S182, LC A184, LC V191, LC S202, LC S203, LC T206, heavy chain (HC) S160, HC T190, HC S443, HC S447, HC S139, HC S168, HC V170, HC V176, HC T200, HC S445 according to a positional numbering convention.

Abstract: Antibodies having modified constant regions so as to permit conjugation of the antibody to a payload such as a therapeutic agent are described. Preferred antibodies include a mutation at light chain position 180 (positional numbering), most preferably the mutation is to a residue selected from C, K, Q, or a non-natural amino acid. Additional mutations may also be combined with a mutation at position 180; including one or more of light chain (LC) S208, LC S171, LC S182, LC A184, LC V191, LC S202, LC S203, LC T206, heavy chain (HC) S160, HC T190, HC S443, HC S447, HC S139, HC S168, HC V170, HC V176, HC T200, HC S445 according to a positional numbering convention.

Abstract: A power amplifier with supply switching is provided. The power amplifier detects a magnitude of an outgoing broadband communication signal and determines whether the magnitude exceeds a predetermined voltage threshold. The power amplifier applies a first gain to the outgoing broadband communication signal using a first voltage supply rail when it is determined that the magnitude exceeds the predetermined voltage threshold and a second gain using a second voltage supply rail that is smaller than the first voltage supply rail when it is determined that the magnitude does not exceed the predetermined voltage threshold. The power amplifier produces an output signal from the outgoing broadband communication signal with the applied first gain or the applied second gain, wherein a current of the outgoing broadband communication signal is switched between the first voltage supply rail and the second voltage supply rail in response to the magnitude being detected.

Abstract: Disclosed is a diagnostic tool configured to evaluate human tissue and associated structures. The device can generate electromagnetic radiation (EMR) at or near a near infrared (NIR) window, the NIR window being a predetermined window that includes a range of wavelengths that allow for maximum penetration depth of the EMR being emitted from the device through tissue. The EMR emitted by the device can form a uniform, diffuse NIR transmission corresponding to the NIR window. A controller can be used to control current supply to the light source so as to modulate the intensity or amplitude of the EMR.

Abstract: A device includes circuitry configured to implement one or more PHY communications protocols to simultaneously communicate with one or more stations via communication links on one or more wireless networks, communicate with additional devices via a backhaul network, and exchange collaboration data, including at least one of protocol data or collaborative beamforming data, with the additional devices via the backhaul network to maintain signal parameters of communications signals with the one or more stations.

Abstract: A power amplifier with supply switching is provided. The power amplifier detects a magnitude of an outgoing broadband communication signal and determines whether the magnitude exceeds a predetermined voltage threshold. The power amplifier applies a first gain to the outgoing broadband communication signal using a first voltage supply rail when it is determined that the magnitude exceeds the predetermined voltage threshold and a second gain using a second voltage supply rail that is smaller than the first voltage supply rail when it is determined that the magnitude does not exceed the predetermined voltage threshold. The power amplifier produces an output signal from the outgoing broadband communication signal with the applied first gain or the applied second gain, wherein a current of the outgoing broadband communication signal is switched between the first voltage supply rail and the second voltage supply rail in response to the magnitude being detected.

Abstract: Broadly speaking, the present invention provides a computer-implemented design method and a system to filter a large selection of mutated antibody sequences, identify those mutated antibody sequences which have particular desired properties, such that the identified sequences can be conjugated to a payload and tested in vitro. Thus, the design and system advantageously remove the need for physical testing of the entire initial selection of molecules, which is complex and costly. Only those which match the pre-defined design criteria may be subject to further experimental testing (in vitro testing) to confirm the results of the computer implemented design. Advantageously, by filtering unsafe molecules during the in silico design process, more time can be spent testing drugs which are predicted to be safe for humans.

Abstract: A power amplifier with supply switching is provided. The power amplifier detects a magnitude of an outgoing broadband communication signal and determines whether the magnitude exceeds a predetermined voltage threshold. The power amplifier applies a first gain to the outgoing broadband communication signal using a first voltage supply rail when it is determined that the magnitude exceeds the predetermined voltage threshold and a second gain using a second voltage supply rail that is smaller than the first voltage supply rail when it is determined that the magnitude does not exceed the predetermined voltage threshold. The power amplifier produces an output signal from the outgoing broadband communication signal with the applied first gain or the applied second gain, wherein a current of the outgoing broadband communication signal is switched between the first voltage supply rail and the second voltage supply rail in response to the magnitude being detected.

Abstract: Provided is a packet network adapter operable to receive a satellite intermediate frequency (IF) signal and determine whether the satellite IF signal includes DVB content based upon a network client request. When the satellite IF signal includes the requested DVB content, the satellite network adapter produces packetized data for delivery of the digital content to a network client or clients based upon the network client request.

Abstract: Antibodies having modified constant regions so as to permit conjugation of the antibody to a payload such as a therapeutic agent are described. Preferred antibodies include a mutation at light chain position 180 (positional numbering), most preferably the mutation is to a residue selected from C, K, Q, or a non-natural amino acid. Additional mutations may also be combined with a mutation at position 180; including one or more of light chain (LC) S208, LC S171, LC S182, LC A184, LC V191, LC S202, LC S203, LC T206, heavy chain (HC) S160, HC T190, HC S443, HC S447, HC S139, HC S168, HC V170, HC V176, HC T200, HC S445 according to a positional numbering convention.

Abstract: A device includes circuitry configured to detect one or more properties of an image signal based on outputs from one or more (analog-to-digital converter) ADC configurations of a transceiver, determine a VCO frequency corresponding to an ADC sampling frequency independently from a carrier frequency, and control the VCO frequency of at least one of a transmitter or receiver based on the one or more properties of the image signal.

Abstract: A power amplifier with supply switching is provided. The power amplifier detects a magnitude of an outgoing broadband communication signal and determines whether the magnitude exceeds a predetermined voltage threshold. The power amplifier applies a first gain to the outgoing broadband communication signal using a first voltage supply rail when it is determined that the magnitude exceeds the predetermined voltage threshold and a second gain using a second voltage supply rail that is smaller than the first voltage supply rail when it is determined that the magnitude does not exceed the predetermined voltage threshold. The power amplifier produces an output signal from the outgoing broadband communication signal with the applied first gain or the applied second gain, wherein a current of the outgoing broadband communication signal is switched between the first voltage supply rail and the second voltage supply rail in response to the magnitude being detected.

Abstract: The present invention relates to methods of controlling the flight path of an aircraft to follow as closely as possible a predetermined four-dimensional flight path, such as when flying continuous descent approaches. A method of controlling an aircraft to follow a predetermined four-dimensional flight path is provided that comprises monitoring the actual along-track position and the actual vertical position of the aircraft relative to the corresponding desired positions on the predetermined flight path. The aircraft's elevators are used to correct deviations of the along-track position and the aircraft's throttle is used to correct deviations of the vertical position.

Abstract: A device includes circuitry configured to detect one or more properties of an image signal based on outputs from one or more (analog-to-digital converter) ADC configurations of a transceiver, determine a VCO frequency corresponding to an ADC sampling frequency independently from a carrier frequency, and control the VCO frequency of at least one of a transmitter or receiver based on the one or more properties of the image signal.

Abstract: A device includes circuitry configured to implement one or more PHY communications protocols to simultaneously communicate with one or more stations via communication links on one or more wireless networks, communicate with additional devices via a backhaul network, and exchange collaboration data, including at least one of protocol data or collaborative beamforming data, with the additional devices via the backhaul network to maintain signal parameters of communications signals with the one or more stations.

Abstract: A device includes circuitry configured to determine noise shaping parameters for one or more transmit signals on one or more transmit channels based on transmission protocol and spectral mask criteria. Frequency positions are identified for the one or more transmit channels based on the noise shaping parameters, and the noise shaping parameters are applied to the one or more transmit signals.

Abstract: A device includes circuitry configured to determine noise shaping parameters for one or more transmit signals on one or more transmit channels based on transmission protocol and spectral mask criteria. Frequency positions are identified for the one or more transmit channels based on the noise shaping parameters, and the noise shaping parameters are applied to the one or more transmit signals.

Abstract: A device includes circuitry configured to assess a broadband spectrum environment including signal and blocker characteristics via one or more receiver paths, determine operational parameters for the device based on the signal and blocker characteristics, and align one or more radio components from one or more radios for operation based on the operational parameters of the device.

Abstract: A method and apparatus is disclosed to couple a transmission amplifier and a reception amplifier to a shared medium. An output of the transmission amplifier is directly coupled to an input of the reception amplifier to form a common connection. The transmission amplifier and the reception amplifier may receive a first amplifier bias via the common connection. In response to the first amplifier bias, the transmission amplifier provides a first communication signal to the shared medium and the reception amplifier does not provide a second communication signal from the shared medium. Alternatively, the transmission amplifier and the reception may receive a second amplifier bias via the common connection. In response to the second amplifier bias, the reception amplifier provides the second communication signal from the shared medium and the transmission amplifier does not provide the first communication signal to the shared medium.