Patents by Inventor Ramon RUHÍ ROURA
Ramon RUHÍ ROURA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11046722Abstract: The present invention relates to sulphated disaccharides of formula (I) for use in the treatment of neuropathic pain. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I) and at least one pharmaceutically acceptable excipient for use in the treatment of neuropathic pain. The compounds of formula (I) were effective in several experimental models of neuropathic pain for which reason these compounds can be used effectively for the treatment of different types of neuropathic pain and the clinical manifestations thereof, for example, mechanical allodynia or cold allodynia.Type: GrantFiled: March 6, 2018Date of Patent: June 29, 2021Assignees: BIOBERICA, S.A.U., UNIVERSIDAD AUTONOMA DE MADRID, FUNDACION TEOFILO HERNANDOInventors: Josep Vergés Milano, Eulàlia Montell Bonaventura, Ramon Ruhí Roura, Carlos Raúl Aláez Versón, Antonio García García, Manuela García López, Juan Fernando Padín Nogueira, Marcos Maroto Pérez, Javier Egea Máiquez
-
Patent number: 10729728Abstract: The present invention refers to a process for preparing an animal brain extract. It also refers to the brain extract obtainable according to said process and to the use thereof as a medicine, in particular for the prevention and/or treatment of neurodegenerative diseases and disorders of the central nervous system. It also refers to compositions comprising this extract and to its use for preparing these compositions.Type: GrantFiled: April 25, 2016Date of Patent: August 4, 2020Assignee: BIOIBERICA, S.A.Inventors: Josep Escaich Ferrer, Daniel Martinez Puig, Pere Dalmau Castañares, Ramon Ruhi Roura, Joaquima Guix Salichs, Josep Ribas Maynou, Artur Alfocea Egüén, Antonio Garcia Pedrosa, Purificación Morales García, Pere Leon Martín, Marta Badias Eroles
-
Publication number: 20200102339Abstract: The present invention relates to sulphated disaccharides of formula (I) for use in the treatment of neuropathic pain. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I) and at least one pharmaceutically acceptable excipient for use in the treatment of neuropathic pain. The compounds of formula (I) were effective in several experimental models of neuropathic pain for which reason these compounds can be used effectively for the treatment of different types of neuropathic pain and the clinical manifestations thereof, for example, mechanical allodynia or cold allodynia.Type: ApplicationFiled: March 6, 2018Publication date: April 2, 2020Inventors: Josep VÉRGES MILANO, Eulàlia MONTELL BONAVENTURA, Ramon RUHÍ ROURA, Carlos Raúl ALÁEZ VERSÓN, Antonio GARCÍA GARCÍA, Manuela GARCÍA LÓPEZ, Juan Fernando PADÍN NOGUEIRA, Marcos MAROTO PÉREZ, Javier EGEA MÁlQUEZ
-
Publication number: 20180140638Abstract: The present invention refers to a process for preparing an animal brain extract. It also refers to the brain extract obtainable according to said process and to the use thereof as a medicine, in particular for the prevention and/or treatment of neurodegenerative diseases and disorders of the central nervous system. It also refers to compositions comprising this extract and to its use for preparing these compositions.Type: ApplicationFiled: April 25, 2016Publication date: May 24, 2018Applicant: BIOIBERICA, S.A.Inventors: Josep ESCAICH FERRER, Daniel MARTINEZ PUIG, Pere DALMAU CASTAÑARES, Ramon RUHI ROURA, Joaquima GUIX SALICHS, Josep RIBAS MAYNOU, Artur ALFOCEA EGÜÉN, Antonio GARCIA PEDROSA, Purificación MORALES GARCÍA, Pere LEON MARTÍN, Marta BADIAS EROLES
-
Patent number: 9687525Abstract: The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.Type: GrantFiled: April 20, 2016Date of Patent: June 27, 2017Assignee: BIOIBERICA, S.A.Inventors: Josep Escaich Ferrer, Pere Dalmau Castanares, Ana Maria Torrent Gibert, Ramon Ruhi Roura, Carlos Raul Alaez Verson
-
Publication number: 20160228508Abstract: The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.Type: ApplicationFiled: April 20, 2016Publication date: August 11, 2016Applicant: BIOIBERICA, S.A.Inventors: Josep ESCAICH FERRER, Pere DALMAU CASTANARES, Ana Maria TORRENT GIBERT, Ramon RUHI ROURA, Carlos Raul ALAEZ VERSON
-
Patent number: 9347081Abstract: The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.Type: GrantFiled: April 16, 2012Date of Patent: May 24, 2016Assignee: BIOIBERICA, S.A.Inventors: Josep Escaich Ferrer, Pere Dalmau Castanares, Ana Maria Torrent Gibert, Ramon Ruhi Roura, Carlos Raul Alaez Verson
-
Patent number: 8785416Abstract: The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.Type: GrantFiled: December 22, 2010Date of Patent: July 22, 2014Assignees: Bioiberica, S.A., Universidad Autonoma de MadridInventors: Josep Verges Milano, Antonio Garcia Garcia, Ramon Ruhi Roura, Eulalia Montell Bonaventura, Manuela Garcia Lopez, Carlos Raul Alaez Verson, Josep Escaich Ferrer, Javier Egea Maiquez, Pilar Negredo Madrigal, Silvia Lorrio Gonzalez
-
Publication number: 20140113861Abstract: The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.Type: ApplicationFiled: April 16, 2012Publication date: April 24, 2014Applicant: BIOIBERICA, S.A.Inventors: Josep Escaich Ferrer, Pere Dalmau Castanares, Ana Maria Torrent Gibert, Ramon Ruhi Roura, Carlos Raul Alaez Verson
-
Patent number: 8445462Abstract: The present invention relates to compositions comprising chondroitin sulphate and mannosamine or a derivative thereof. The mannosamine derivative is preferably N-acetylmannosamine. The compositions may comprise glucosamine. Said compositions are useful in the treatment or prevention of degenerative joint diseases, preferably of osteoarthritis, in the treatment or prevention of tendon or ligament diseases, disorders or injuries and of immune system diseases, preferably of rheumatoid arthritis.Type: GrantFiled: December 17, 2008Date of Patent: May 21, 2013Assignee: Bioiberica, S.A.Inventors: Josep Escaich Ferrer, Ana Maria Torrent Gibert, Ramon Ruhi Roura, Pere Dalmau Castanares
-
Patent number: 8394781Abstract: Disaccharides for the treatment of tendons, ligaments and bones. The present invention relates to the use of a series of disaccharides, as well as of compositions containing them, for the preparation of a medicament for the treatment or prevention of a tendon, ligament or bone disease, disorder or injury. The present invention also relates to the new compositions comprising a disaccharide in combination with inulin polysulphate, a glycosaminoglycan, a growth factor or cells. The glycosaminoglycan is preferably chondroitin sulphate or hyaluronic acid and the growth factor is IFG-1.Type: GrantFiled: May 15, 2008Date of Patent: March 12, 2013Assignee: Bioiberica, S.A.Inventors: Josep Escaich Ferrer, Ana Maria Torrent Gibert, Ramon Ruhi Roura, Carlos Raul Alaez Verson
-
Publication number: 20120309707Abstract: The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.Type: ApplicationFiled: December 22, 2010Publication date: December 6, 2012Applicants: UNIVERSIDAD AUTONOMA DE MADRID, BIOIBERICA, S.A.Inventors: Josep Verges Milano, Antonio Garcia Garcia, Ramon Ruhi Roura, Eulalia Montell Bonaventura, Manuela Garcia Lopez, Carlos Raul Alaez Verson, Josep Escaich Ferrer, Javier Egea Maiquez, Pilar Negredo Madrigal, Silvia Lorrio Gonzalez
-
Patent number: 7943598Abstract: The present invention relates to the use of an organic glucosamine salt selected from glucosamine glucuronate, glucosamine ascorbate, glucosamine malate, glucosamine hydrogen malate, glucosamine citrate, glucosamine hydrogen citrate, and glucosamine dihydrogen citrate for the preparation of a medicament for the treatment of arthrosis and inflammation and pain associated with arthrosis. The present invention also relates to the use of an organic glucosamine salt, selected from the ones mentioned above, for the preparation of a nutritional supplement acting as a chondroprotector, to nourish the cartilage, protect the joints, prevent water deficit in the tissues that form the joint, improve the joints' functional capacity, elasticity, and flexibility, and prevent and revert the physical overexertion syndrome in athletes, and the effects associated therewith.Type: GrantFiled: June 23, 2005Date of Patent: May 17, 2011Assignee: Bioiberica, S.A.Inventors: Josep Escaich Ferrer, Ramon Ruhi Roura, Ana Maria Torrent Gibert
-
Publication number: 20100286086Abstract: The present invention relates to compositions comprising chondroitin sulphate and mannosamine or a derivative thereof. The mannosamine derivative is preferably N-acetylmannosamine. The compositions may comprise glucosamine. Said compositions are useful in the treatment or prevention of degenerative joint diseases, preferably of osteoarthritis, in the treatment or prevention of tendon or ligament diseases, disorders or injuries and of immune system diseases, preferably of rheumatoid arthritis.Type: ApplicationFiled: December 17, 2008Publication date: November 11, 2010Applicant: BIOIBERICA, S.A.Inventors: Josep Escaich Ferrer, Ana Maria Torrent Gibert, Ramon Ruhi Roura, Pere Dalmau Castanares
-
Patent number: 7816329Abstract: The present invention relates to the use of a sulphated polysaccharide in acid form or as a physiologically acceptable salt thereof, selected from the group constituting of inulin sulphate, gellan sulphate, pullulan sulphate, curdlan sulphate, alginiq acid sulphate, laminarin sulphate, and pectin sulphate, for the preparation of a medicament for the treatment or prophylaxis of arthrosis in a mammal. Preferably, the sulphated polysaccharide is inulin sulphate, most preferably inulin polysulphate sodium salt. The present invention also relates to the use of a sulphated oligosaccharide derived from a polysaccharide selected from the group consisting of inulin, gellan, pullulan, curdlan, alginic acid, laminarin, and pectin, for the preparation of a medicament for the treatment or prophylaxis of arthrosis in a mammal.Type: GrantFiled: February 11, 2005Date of Patent: October 19, 2010Assignee: Bioiberica, S.A.Inventors: Francisco Javier Vila Pahi, Josep Escaich Ferrer, August Lodewijk Verbruggen, Josep Verges Milano, Ramon Ruhi Roura, Carlos Raul Alaez Verson
-
Publication number: 20100129331Abstract: The present invention relates to the use of a series of disaccharides, as well as of compositions containing them, for the preparation of a medicament for the treatment or prevention of a tendon, ligament or bone disease, disorder or injury. The present invention also relates to the new compositions comprising a disaccharide in combination with inulin polysulphate, a glycosamino-glycan, a growth factor or cells. The glycosaminoglycan is preferably chondroitin sulphate or hyaluronic acid and the growth fact is IFG-1.Type: ApplicationFiled: May 15, 2008Publication date: May 27, 2010Applicant: BIOIBERICA, S.A.Inventors: Josep Escaich Ferrer, Ana Maria Torrent Gibert, Ramon Ruhi Roura, Carlos Raul Alaez Verson
-
Publication number: 20080051350Abstract: The present invention relates to the use of a sulphated polysaccharide in acid form or as a physiologically acceptable salt thereof, selected from the group consisting of inulin sulphate, gellan sulphate, pullulan sulphate, curdlan sulphate, alginiq acid sulphate, laminarin sulphate, and pectin sulphate, for the preparation of a medicament for the treatment or prophylaxis of arthrosis in a mammal. Preferably, the sulphated polysaccharide is inulin sulphate, most preferably inulin polysulphate sodium salt. The present invention also relates to the use of a sulphated oligosaccharide derived from a polysaccharide selected from the group consisting of inulin, gellan, pullulan, curdlan, alginic acid, laminarin, and pectin, for the preparation of a medicament for the treatment or prophylaxis of arthrosis in a mammal.Type: ApplicationFiled: February 11, 2005Publication date: February 28, 2008Applicant: Bioiberica, S.A.Inventors: Francisco Javier Vila Pahi, Josep Escaich Ferrer, August Lodewijk Verbruggen, Josep Verges Milano, Ramon Ruhi Roura, Carlos Raul Alaez Verson
-
Publication number: 20070244070Abstract: The present invention relates to the use of an organic glucosamine salt selected from glucosamine glucuronate, glucosamine ascorbate, glucosamine malate, glucosamine hydrogen malate, glucosamine citrate, glucosamine hydrogen citrate, and glucosamine dihydrogen citrate for the preparation of a medicament for the treatment of arthrosis and inflammation and pain associated with arthrosis. The present invention also relates to the use of an organic glucosamine salt, selected from the ones mentioned above, for the preparation of a nutritional supplement acting as a chondroprotector, to nourish the cartilage, protect the joints, prevent water deficit in the tissues that form the joint, improve the joints' functional capacity, elasticity, and flexibility, and prevent and revert the physical overexertion syndrome in athletes, and the effects associated therewith.Type: ApplicationFiled: June 23, 2005Publication date: October 18, 2007Applicant: BIOIBERICA, S.A.Inventors: Jose Escaish Ferrer, Ramon Ruhi Roura, Ana Torrent Gibert
-
Patent number: 7141556Abstract: This invention relates to a process for the preparation of glucosamine sulfate, glucosamine hydroiodide, glucosamine pyruvate, glucosamine phosphate or their mixtures with glucosamine hydrochloride, by electrodialysis. Starting from glucosamine hydrochloride, the exchange of the Cl? for an anion selected from the group consisting of SO4 ?2, I?, CH3COCOO? and PO4?3 takes place during the process. The electrodialyser comprises a cathode, anode, and means of separation composed of anion exchange membranes, cation exchange membranes, bipolar membranes or by other suitable means of separation. This invention also relates to a glycosamine sulphate containing chlorides obtainable by the process, and its therapeutic use.Type: GrantFiled: December 13, 2002Date of Patent: November 28, 2006Assignee: Bioiberica, S.A.Inventors: Francisco Javier Vila Pahi, Ricard Mis Vizcaino, Ramon Ruhi Roura, Ana Maria Torrent Gibert, Vicente Montiel Leguey, Vicente Garcia Garcia, Eduardo Exposito Rodriguez, Antonio Aldaz Riera, Carlos Raul Alaez Verson
-
Publication number: 20050014720Abstract: This invention relates to a process for the preparation of glucosamine hydroiodide, glucosamine pyruvate, glucosamine phosphate or their mixtures with glucosamine hydrochloride, by electrodialysis. Starting from glucosamine hydrochloride, the exchange of the Cl? for an anion selected from the group consisting of SO4 ?2, I?, CH3COCOO? and PO4?3 takes place during the process. The electrodialysis, that comprises a cathode, anode, and means of separation composed of anion exchange membranes, cation exchange membranes, bipolar membranes or by other suitable means of separation. This invention also relates to a glycosamine sulphate containing chlorides obtainable by the process, and its therapeutic use.Type: ApplicationFiled: December 13, 2002Publication date: January 20, 2005Inventors: Francisco Vila Pahi, Ricard Mis Vizcaino, Ramon Ruhi Roura, Ana Maria Torrent Gibert, Vicente Montiel Leguey, Vicente Garcia Garcia, Eduardo Exposito Rodriguez, Antonio Aldaz Riera, Carlos Alaez Verson