Patents by Inventor Randal H. Eckert
Randal H. Eckert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11707431Abstract: In certain embodiments a dental strip for the prevention or reduction of dental caries is provided. In certain embodiments the dental strip is constructed to deliver effective amounts of specifically targeted antimicrobial peptides (or simple antimicrobial peptides) and comprises an orally compatible backing layer, a delivery layer disposed on one surface of the backing layer where the delivery layer comprises an orally compatible polymer, or combination of polymers, and a specifically targeted antimicrobial peptide (and/or simple antimicrobial peptide) capable of binding and killing Streptococcus mutans. In certain embodiments the dental strip additionally comprises a release liner.Type: GrantFiled: April 12, 2018Date of Patent: July 25, 2023Assignee: C3 Jian, LLCInventors: Evan Schauer, Miroslav Baudys, Brian C. Varnum, Duane Morris, Christopher W. Kaplan, Randal H. Eckert
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Patent number: 11633341Abstract: In various embodiments a dental varnish system having improved peptide release and fluoride release properties is provided. In various embodiments a dental varnish system that provides release of an antimicrobial peptide, or specifically targeted antimicrobial peptide (STAMP), e.g., the peptide C16G2, is provided, with or without a fluoride. In various embodiments, a dental varnish system that provides release of a fluoride, with or without an antimicrobial peptide or STAMP is provided. In certain embodiments the dental varnish system comprises a first component that is a dry powder, said first component comprising a an antimicrobial peptide, with or without a fluoride, and a bulking agent, and a second component that is a fluid, said second component comprising a varnish solution, where combination of said first component with said second component provides a varnish formulation for application to the surface of a tooth.Type: GrantFiled: April 12, 2018Date of Patent: April 25, 2023Assignee: C3 Jian, LLCInventors: Evan Schauer, Miroslav Baudys, Brian C. Varnum, Christopher W. Kaplan, Randal H. Eckert, Jay Turetzky, Angela Soriaga
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Publication number: 20200276103Abstract: In various embodiments a dental varnish system having improved peptide release and fluoride release properties is provided. In various embodiments a dental varnish system that provides release of an antimicrobial peptide, or specifically targeted antimicrobial peptide (STAMP), e.g., the peptide C16G2, is provided, with or without a fluoride. In various embodiments, a dental varnish system that provides release of a fluoride, with or without an antimicrobial peptide or STAMP is provided. In certain embodiments the dental varnish system comprises a first component that is a dry powder, said first component comprising a an antimicrobial peptide, with or without a fluoride, and a bulking agent, and a second component that is a fluid, said second component comprising a varnish solution, where combination of said first component with said second component provides a varnish formulation for application to the surface of a tooth.Type: ApplicationFiled: April 12, 2018Publication date: September 3, 2020Inventors: Evan Schauer, Miroslav Baudys, Brian C. Varnum, Christopher W. Kaplan, Randal H. Eckert, Jay Turetzky, Angela Soriaga
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Publication number: 20200113818Abstract: In certain embodiments a dental strip for the prevention or reduction of dental caries is provided. In certain embodiments the dental strip is constructed to deliver effective amounts of specifically targeted antimicrobial peptides (or simple antimicrobial peptides) and comprises an orally compatible backing layer, a delivery layer disposed on one surface of the backing layer where the delivery layer comprises an orally compatible polymer, or combination of polymers, and a specifically targeted antimicrobial peptide (and/or simple antimicrobial peptide) capable of binding and killing Streptococcus mutans. In certain embodiments the dental strip additionally comprises a release liner.Type: ApplicationFiled: April 12, 2018Publication date: April 16, 2020Inventors: Evan Schauer, Miroslav Baudys, Brian C. Varnum, Duane Morris, Christopher W. Kaplan, Randal H. Eckert
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Patent number: 10111926Abstract: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.Type: GrantFiled: May 24, 2016Date of Patent: October 30, 2018Assignees: The Regents of the University of California, C3 Jian, LLCInventors: Randal H. Eckert, Daniel K. Yarbrough, Wenyuan Shi, Maxwell H. Anderson, Fengxia Qi, Jian He, Ian H. McHardy
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Publication number: 20170266306Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: ApplicationFiled: February 15, 2017Publication date: September 21, 2017Inventors: RANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Patent number: 9597407Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: GrantFiled: April 17, 2014Date of Patent: March 21, 2017Assignee: C3 JIAN, LLCInventors: Randal H. Eckert, Chris Kaplan, Jian He, Daniel K. Yarbrough, Maxwell Anderson, Jee-Hyun Sim
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Publication number: 20160331804Abstract: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.Type: ApplicationFiled: May 24, 2016Publication date: November 17, 2016Applicant: C3 Jian, Inc.Inventors: Randal H. Eckert, Daniel K. Yarbrough, Wenyuan Shi, Maxwell H. Anderson, Fengxia Qi, Jian He, Ian H. McHardy
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Publication number: 20160207969Abstract: In certain embodiments, constructs are provided that selectively/preferentially inhibit and/or kill Clostridium difficile. In certain embodiments the constructs comprise a peptide that binds C. difficile attached directly or through an amino acid or a linker to an antimicrobial peptide.Type: ApplicationFiled: December 28, 2015Publication date: July 21, 2016Inventors: Shaoying Lee, Miroslav Baudys, Randal H. Eckert, Brian C. Varnum, Vlad Omel
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Patent number: 9351490Abstract: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.Type: GrantFiled: February 11, 2014Date of Patent: May 31, 2016Assignee: The Regents of the University of CaliforniaInventors: Randal H. Eckert, Daniel K. Yarbrough, Wenyuan Shi, Maxwell H. Anderson, Fengxia Qi, Jian He, Ian H. McHardy
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Publication number: 20160031941Abstract: In certain embodiments, novel targeting peptides that specifically/preferentially bind to S. mutans are provided. The targeting peptides can be attached to effectors (e.g., detectable labels, drugs, antimicrobial peptides, etc.) to form chimeric constructs for specifically/preferentially delivering the effector to and/or into the target organism. In certain embodiments the targeting peptides attached, e.g., to antimicrobial peptides can be used to selectively inhibit and/or kill S. mutans and, when used in the oral cavity of a mammal, can be effective to reduce the incidence and/or severity of dental caries and/or the incidence and/or severity of periodontal disease.Type: ApplicationFiled: July 8, 2015Publication date: February 4, 2016Inventors: Randal H. Eckert, Christopher W. Kaplan, Pierre A. Kyme, Brian C. Varnum
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Patent number: 9072793Abstract: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.Type: GrantFiled: October 16, 2012Date of Patent: July 7, 2015Assignee: C3 Jian, Inc.Inventors: Randal H. Eckert, Chris Kaplan, Jian He, Daniel K. Yarbrough, Maxwell Anderson, Jee-Hyun Sim
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Publication number: 20140349917Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: ApplicationFiled: April 17, 2014Publication date: November 27, 2014Applicant: C3 JIAN, INC.Inventors: RANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Publication number: 20140314691Abstract: In various embodiments compositions are provided for the whitening, and/or brightening, and/or restoration of a tooth. In various embodiments the compositions, referred to herein as “dental care” compositions typically comprise a binding moiety that binds to calcium and/or to tooth enamel and/or to pellicle attached to an active agent. The active agent is selected to deliver a particular activity (e.g., whitening, remineralization, desensitization, brightening, etc.) to the tooth.Type: ApplicationFiled: March 11, 2014Publication date: October 23, 2014Applicant: C3 JIAN, INC.Inventors: Randal H. ECKERT, Daniel K. YARBROUGH, Brian C. VARNUM
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Patent number: 8754039Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: GrantFiled: January 6, 2010Date of Patent: June 17, 2014Assignee: C3 Jian, Inc.Inventors: Randal H. Eckert, Chris Kaplan, Jian He, Daniel K. Yarbrough, Maxwell Anderson, Jee-Hyun Sim
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Publication number: 20140155317Abstract: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.Type: ApplicationFiled: February 11, 2014Publication date: June 5, 2014Applicants: C3 JIAN, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Randal H. Eckert, Daniel K. Yarbrough, Wenyuan Shi, Maxwell H. Anderson, Fengxia Qi, Jian He, Ian H. McHardy
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Patent number: 8680058Abstract: The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.Type: GrantFiled: November 2, 2010Date of Patent: March 25, 2014Assignees: The Regents of the University of California, C3 Jian, Inc.Inventors: Randal H. Eckert, Daniel K. Yarbrough, Wenyuan Shi, Maxwell H. Anderson, Fengxia Qi, Jian He, Ian H. McHardy
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Patent number: 8609608Abstract: This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against Streptococcus mutans a common oral pathogen and the causative agent of dental caries.Type: GrantFiled: March 24, 2010Date of Patent: December 17, 2013Assignees: C3 Jian, Inc., The Regents of the University of CaliforniaInventors: Jian He, Randal H. Eckert, Fengxia Qi, Maxwell H. Anderson, Wenyuan Shi
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Patent number: 8389679Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: GrantFiled: February 5, 2010Date of Patent: March 5, 2013Assignee: The Regents of the University of CaliforniaInventors: Randal H. Eckert, Daniel Yarbrough, Wenyuan Shi, Maxwell Anderson, Jian He, Chris Kaplan, Jee-Hyun Sim
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Patent number: 8303962Abstract: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.Type: GrantFiled: January 6, 2010Date of Patent: November 6, 2012Assignee: C3 Jian, Inc.Inventors: Randal H. Eckert, Chris Kaplan, Jian He, Daniel K. Yarbrough, Maxwell Anderson, Jee-Hyun Sim