Abstract: The present disclosure is directed to polypeptides, such as polypeptides comprising an alkaline phosphatase and a bone-targeting moiety. Also disclosed are expression vectors, such as lentiviral expression vectors, including a nucleotide sequence encoding a polypeptide. Also disclosed are methods of treating hypophosphatasia or treating, mitigating, or preventing one or more symptoms of hypophosphatasia by administering to a subject in need of treatment thereof the disclosed polypeptides or host cells transduced to express any of the disclosed polypeptides.

Abstract: A mobile cooler including a compartment having pivotable wheels and a handle assembly for pulling the cooler. A pair of wheel assemblies individually pivot within recesses in the cooler from a raised to a lowered position. In the lowered position the cooler can be transported over smooth or uneven terrain. The handle telescopes partly into the compartment, and partly folds down by a pair of hinges to fit within recesses in the compartment lid. The handle length can be adjusted to suit the user.

Abstract: An abdominal/back exerciser is disclosed. The exerciser includes a frame having spaced side members and a seat attached to the frame between the side members. Foot braces extend between the side members on each side of the seat. A generally U-shaped lever assembly includes parallel side legs and a padded torso-engaging member interconnecting the side legs. The side legs are pivotally connected to the side members at a pivot axis intermediate their length. Weights are mounted at the distal end of each side leg. A stop mechanism limits the downward movement of the side legs to a start position wherein the torso-engaging member is elevated above the seat, whereby a user seated on the seat can lean against the torso-engaging member and rotate the lever assembly to raise the weights thereby exercising his abdominal muscles when facing the torso-engaging member or exercising his lower back muscles when seated with his back to the torso-engaging member.