Patents by Inventor Randall Bateman

Randall Bateman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING BASED ON SITE-SPECIFIC TAU PHOSPHORYLATION
    Publication number: 20230341421
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Application
    Filed: April 24, 2023
    Publication date: October 26, 2023
    Inventors: Nicolas Barthelemy, Randall Bateman, Eric McDade
  • CSF PHOSPHORYLATED TAU AND AMYLOID BETA PROFILES AS BIOMARKERS OF TAUOPATHIES
    Publication number: 20230280357
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues and optionally Ab species to diagnose a subject, guide treatment decisions, and select subjects for clinical trials.
    Type: Application
    Filed: March 31, 2022
    Publication date: September 7, 2023
    Inventors: CHIHIRO SATO, NICOLAS BARTHELEMY, RANDALL BATEMAN
  • Uses of Tau Phosphosites as Biomarkers for Alzheimer's Disease
    Publication number: 20230132508
    Abstract: The present disclosure relates to methods of measuring and analyzing phosphorylation sites in the tau protein and determining correlations with other biomarkers of Alzheimer's disease and tauopathies.
    Type: Application
    Filed: March 31, 2021
    Publication date: May 4, 2023
    Applicants: Genentech Inc., Washington University
    Inventors: Kristin Ruth Wildsmith, Balazs Toth, Randall Bateman, Nicolas Barthelemy
  • Methods of treating based on site-specific tau phosphorylation
    Patent number: 11635440
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Grant
    Filed: June 17, 2022
    Date of Patent: April 25, 2023
    Assignee: Washington University
    Inventors: Nicolas Barthelemy, Randall Bateman, Eric McDade
  • BLOOD-BASED ASSAY FOR DIAGNOSING AND TREATING BASED ON SITE-SPECIFIC TAU PHOSPHORYLATION
    Publication number: 20230017557
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues, using blood samples, to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Application
    Filed: September 10, 2020
    Publication date: January 19, 2023
    Inventors: RANDALL BATEMAN, NICOLAS BARTHELEMY
  • METHODS OF TREATING BASED ON SITE-SPECIFIC TAU PHOSPHORYLATION
    Publication number: 20220317136
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Application
    Filed: June 17, 2022
    Publication date: October 6, 2022
    Inventors: Nicolas Barthelemy, Randall Bateman, Eric McDade
  • METHODS TO DETECT MTBR TAU ISOFORMS AND USE THEREOF
    Publication number: 20220299527
    Abstract: The methods disclosed herein employ unique combinations of processing steps that transform a blood or CSF sample into a sample suitable for quantifying MTBR tau species, as well as other tau species. The present disclosure also encompasses the use of MTBR tau species in blood or CSF to measure pathological features and/or clinical symptoms of 3R- and 4R-tauopathies in order to diagnose, stage, and/or choose treatments appropriate for a given disease stage, and modify a given treatment regimen.
    Type: Application
    Filed: August 13, 2020
    Publication date: September 22, 2022
    Inventors: RANDALL BATEMAN, CHIHIRO SATO, KANTA HORIE, NICOLAS BARTHELEMY
  • Methods of treating based on site-specific tau phosphorylation
    Patent number: 11402392
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: August 2, 2022
    Assignee: Washington University
    Inventors: Nicolas Barthelemy, Randall Bateman, Eric McDade
  • MULTIPLEXED ASSAY AND METHODS OF USE THEREOF
    Publication number: 20220120765
    Abstract: The present disclosure provides methods for blood-based examination useful to identify subjects with A? amyloidosis and/or to identify subjects who should or should not undergo further testing or treatment for A? amyloidosis, as well as methods for treating subjects diagnosed with A? amyloidosis by the methods disclosed herein.
    Type: Application
    Filed: January 9, 2020
    Publication date: April 21, 2022
    Inventors: Melissa Budelier, Randall Bateman
  • METHODS FOR TREATING TAUOPATHIES
    Publication number: 20220064271
    Abstract: This invention relates to epitope binding agents that specifically bind to tau and methods of use thereof. The disclosure provides immunoassays, kits, and pharmaceutical compositions which include an epitope binding agent that specifically bind to tau. The disclosure provides methods of reducing the spread of tau aggregates and methods of reducing a tauopathy-related pathology.
    Type: Application
    Filed: September 1, 2021
    Publication date: March 3, 2022
    Inventors: Randall Bateman, David Holtzman, Kanta Horie, Nicolas Barthelemy, Chihiro Sato, Hong Jiang
  • METHODS OF TREATING BASED ON SITE-SPECIFIC TAU PHOSPHORYLATION
    Publication number: 20210341495
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Application
    Filed: July 6, 2021
    Publication date: November 4, 2021
    Inventors: Nicolas Barthelemy, Randall Bateman, Eric McDade
  • BLOOD-BASED METHODS FOR DETERMING A-BETA AMYLOIDOSIS
    Publication number: 20210255201
    Abstract: The present disclosure provides methods for blood-based examination useful to identify subjects with A? amyloidosis and/or to identify subjects who should or should not undergo further testing or treatment for A? amyloidosis, as well as methods for treating subjects diagnosed with A? amyloidosis by the methods disclosed herein.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 19, 2021
    Inventor: Randall Bateman
  • Methods of treating based on site-specific tau phosphorylation
    Patent number: 11085935
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: August 10, 2021
    Assignee: Washington University
    Inventors: Nicolas Barthelemy, Randall Bateman, Eric McDade
  • TAU KINETIC MEASUREMENTS
    Publication number: 20210096139
    Abstract: The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 1, 2021
    Inventors: Randall Bateman, Chihiro Sato, Kwasi Mawuenyega, Tim Miller, David Holtzman
  • METHODS OF TREATING BASED ON SITE-SPECIFIC TAU PHOSPHORYLATION
    Publication number: 20200400689
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Application
    Filed: September 9, 2020
    Publication date: December 24, 2020
    Inventors: Nicolas Barthelemy, Randall Bateman
  • Tau kinetic measurements
    Patent number: 10830775
    Abstract: The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 10, 2020
    Assignee: Washington University
    Inventors: Randall Bateman, Chihiro Sato, Kwasi Mawuenyega, Tim Miller, David Holtzman
  • TAU KINETIC MEASUREMENTS
    Publication number: 20170307639
    Abstract: The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.
    Type: Application
    Filed: September 30, 2015
    Publication date: October 26, 2017
    Applicant: Washington University
    Inventors: Randall Bateman, Chihiro Sato, Kwasi Mawuenyega, Tim Miller, David Holtzman
  • METHODS FOR DETECTING AMYLOID BETA AMYLOIDOSIS
    Publication number: 20160178646
    Abstract: The present invention relates to methods of detecting, diagnosing, monitoring, and assessing treatment effects for A? amyloidosis, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms.
    Type: Application
    Filed: March 1, 2016
    Publication date: June 23, 2016
    Inventors: Randall Bateman, Kwasi Mawuenyega, Vitaliy Ovod, Anna Bareiss, Tom Kasten, David Holtzman
  • METHOD FOR DETECTING AMYLOID BETA AMYLOIDOSIS
    Publication number: 20160169916
    Abstract: The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for A? amyloidosis, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. Methods of measuring the in vivo metabolism of biomolecules produced in the CNS in a subject are provided.
    Type: Application
    Filed: February 24, 2016
    Publication date: June 16, 2016
    Inventors: David Holtzman, Randall Bateman, Kwasi G. Mawuenyega
  • METHODS OF DIAGNOSING AMYLOID PATHOLOGIES USING ANALYSIS OF AMYLOID-BETA ENRICHMENT KINETICS
    Publication number: 20150254421
    Abstract: A method of diagnosing an amyloid pathology in the central nervous system of a patient using measurements of enrichment kinetics of at least one amyloid-? isoform is provided. In addition, a model to predict enrichment kinetics of at least one amyloid-? isoform, methods of calibrating the model, and methods of using the model to diagnosing an amyloid pathology in the central nervous system of a patient are provided.
    Type: Application
    Filed: May 20, 2015
    Publication date: September 10, 2015
    Inventors: Randall Bateman, Bruce W. Patterson, Donald L. Elbert