Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: An amplifier for electric guitar including a Cut control for attenuating high frequencies whose operation is expanded via a switch to alternately function as a Master Volume control.

Abstract: An amplifier for electric guitar including a Cut control for attenuating high frequencies whose operation is expanded via a switch to alternately function as a Master Volume control.

Abstract: An amplifier for electric guitar including a plurality of foot switch selectable preamplifier channels which can be set to provide differing sonic characteristics, and also including a power amplifier section for driving a loudspeaker that can be switched between at least two different power or performance capabilities. User operable switching dedicated to at least one of the preamplifier channels is provided to select preferred power amplifier parameters in conjunction with differing channel voicings. Thus, differing preferred power amplifier characteristics may be pre-set and assigned to individual preamplifier channels and called up automatically in conjunction with the remote channel selection.

Abstract: Disclosed is a system and a method for designing geometric shapes for automobiles or any other manufactured objects. The method of a vehicle design system is for analyzing constraints on parameters of a vehicle model, the vehicle design system including a catalog of exemplars from which a user may select exemplar input and at least one engineering criteria having a plurality of criteria values from which a user may select criteria values. The method includes providing a morphable vehicle model generated from exemplar input, selecting a first criteria, evaluating the morphable model with respect to the first criteria to determine the value, selecting a new target criteria value from the plurality of criteria values, and updating the morphable model shape to achieve this value.

Abstract: A system, method, apparatus and product for designing, on a display device, a geometric shape is disclosed. The method comprises the steps of displaying an initial set of similarly structured model exemplars on a display device, selecting a chosen set of models from the initial set of similarly structured model exemplars to apply to a model mix, mixing the set of models consisting of a first portion and a second portion to form a currently displayed shape, providing on the display device at least one selectable feature for manipulating the currently displayed shape, and applying a constraint of the selectable feature to the displayed shape to update both the first portion and the second portion of the currently displayed shape into a new geometric shape design. In a particular implementation, the first portion of the geometric shape is an automobile and the second portion is a standardized human occupant representation.

Abstract: A method, system, and apparatus for preparing geometric models for use in a design tool are disclosed. The method comprises generating a first base shape model, separating the first base model into components, and characterizing the components. Further, the method provides for comparing the second base model, similarly prepared and characterized, to the first, and adjusting the features used to characterize the base model components until the two objects can be placed in correspondence. The system comprises a processor capable of processing instructions for generating base shape models wherein the processor is capable of processing instructions for separating a base model into components and further capable of processing instructions for characterizing base model components. Accordingly, the method may provide for defining a geometric model template by adjusting a base model to match a succession of input models.

Abstract: A system, method, apparatus and product for designing, on a display device, a geometric shape is disclosed. The method comprises the steps of displaying an initial set of similarly structured model exemplars on a display device, selecting a chosen set of models from the initial set of similarly structured model exemplars to apply to a model mix, mixing the set of models to form a currently displayed shape, providing on the display device at least one selectable feature for manipulating the currently displayed shape, and applying at least one constraint of the selectable feature to the currently displayed shape to update the currently displayed shape into a new geometric shape design.

Abstract: A guitar amplifier having at least one channel, each channel having a differential amplifier with first and second amplifying members, each amplifying member having a control element, an electron emitting element and an electron collecting element, the electron emitting elements of the amplifying members commonly coupled and an output amplifier coupled to the differential amplifier and having an output terminal selectively coupled to the control element of the second amplifying member of the differential amplifier as a feedback path. An input terminal coupled to the control element of the first amplifying member and a user-adjustable presence control circuit selectively coupled between the control element of the first amplifying member and ground to increase the perceived brightness, when selected. The presence control circuit includes a high pass filter disposed between the input terminal and ground to filter a selected high frequency portion of the signal received at the input terminal.

Abstract: A power supply for a guitar amplifier and the guitar amplifier and method of operating the guitar amplifier. The power supply includes an alternating current power input having a secondary winding and a filament winding, an output and a first vacuum tube rectifier coupled between the secondary winding of the power input and the output for rectifying the alternating current at the power input. At least a second rectifier is provided which is selectively couplable in parallel with the first vacuum tube rectifier. The at least one second rectifier can be a vacuum tube rectifier with each of the first and second rectifiers having a cathode continually energized by the filament winding, a solid state rectifier or both. The output amplifier has an output transformer having a primary winding with a center tap and with a first pair of vacuum tube amplifiers having their cathodes being coupled together and their plates coupled to the primary winding on opposite sides of the center tap.

Abstract: A vacuum tube power amplifier with a user-operable switch and a single output transformer which selectively provides push-pull or single ended configurations for driving a loudspeaker.

Abstract: A guitar amplifier having an input terminal, an audio output and an audio level controller connected between the input terminal and the audio output. The audio level controller includes a first attenuation path, a second attenuation path having a fixed attenuation and a switch connecting only one of the first or second attenuation paths between the input and the audio output. The switch is preferably controlled remote from the amplifier and preferably by a foot-controlled switch. The first attenuation path is preferably variable. The audio level controller can include a first variable resistor coupled to the input terminal and having a wiper coupled to the audio output, the first variable resistor being coupled to a source of reference voltage through a second resistor to form the first attenuation path, the switch being coupled between the junction of the first and second resistors and the source of reference voltage to provide the second attenuation path.

Abstract: A guitar amplifier having at least one channel, each channel having a differential amplifier with first and second amplifying members, each amplifying member having a control element, an electron emitting element and an electron collecting element, the electron emitting elements of the amplifying members commonly coupled and an output amplifier coupled to the differential amplifier and having an output terminal selectively coupled to the control element of the second amplifying member of the differential amplifier as a feedback path. An input terminal coupled to the control element of the first amplifying member and a user-adjustable presence control circuit selectively coupled between the control element of the first amplifying member and ground to increase the perceived brightness, when selected. The presence control circuit includes a high pass filter disposed between the input terminal and ground to filter a selected high frequency portion of the signal received at the input terminal.

Abstract: A mute circuit for momentarily inhibiting signal travel in the signal path having an input terminal and an output terminal in response to operation of a coil-operated relay. The signal path will preferably include a plurality of channel in parallel. A plurality of switch responsive coil-operated relays are disposed in the signal path with a separate unidirectional signal path coupling each of the coils of each of the coil-operated relays to a muting line with the coil of each said relay providing a signal on the muting line responsive to collapse of the magnetic field developed in the relay coil by the flow of current therethrough. A plurality of time controlled switching devices are responsive to a signal on the muting line from a coil to momentarily inhibit signal travel in the signal path. The timing circuit is included in the time controlled switching device to control the length of operation of the switch in response to a signal on the muting circuit.

Abstract: A power supply for a guitar amplifier and the guitar amplifier and method of operating the guitar amplifier. The power supply includes an alternating current power input having a secondary winding and a filament winding, an output and a first vacuum tube rectifier coupled between the secondary winding of the power input and the output for rectifying the alternating current at the power input. At least a second rectifier is provided which is selectively couplable in parallel with the first vacuum tube rectifier. The at least one second rectifier can be a vacuum tube rectifier with each of the first and second rectifiers having a cathode continually energized by the filament winding, a solid state rectifier or both. The output amplifier has an output transformer having a primary winding with a center tap and with a first pair of vacuum tube amplifiers having their cathodes being coupled together and their plates coupled to the primary winding on opposite sides of the center tap.

Abstract: A multi-mode preamplifier for electric guitar comprising substantially parallel arrangement of at least two dissimilar channels of amplifying stages wherein one channel is dedicated to rhythm mode performance while the other is dedicated to one or more distortion producing modes.

Abstract: An electronic amplifying apparatus for sound reproduction and musical instrument amplification including at least two pairs of power output devices which are independently switchable between triode and pentode operation. The amplifier further contains a switch apparatus to select the amount of negative feedback within the amplifier.

Abstract: A power output amplifier for use with electric guitar wherein the individual pairs of power tubes are of two or more differing types which may be selected by the user to operate alternately or simultaneously.

Abstract: A power supply for use with a musical amplifier includes two user-selectable rectifiers for variously enhancing sound generated by a musical instrument such as a guitar, or by recorded musical material which in either case consists of electrical signals applied to a vacuum tube amplifying apparatus. The first of two rectifiers comprises one or more thermionic vacuum tube devices, depending upon power needs, while the second rectifier is comprised of solid-state silicon diodes. A switch circuit enables the user to select which of the two rectifier devices is better suited to the contemporaneous use of the amplifier.