Patents by Inventor Randall D. Little
Randall D. Little has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170066818Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: ApplicationFiled: November 16, 2016Publication date: March 9, 2017Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josee Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil D. Pandit
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Publication number: 20160222098Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: ApplicationFiled: March 17, 2016Publication date: August 4, 2016Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josee Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil D. Pandit
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Publication number: 20150361162Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: ApplicationFiled: December 8, 2014Publication date: December 17, 2015Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josee Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil D. Pandit
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Patent number: 8907067Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: GrantFiled: December 30, 2011Date of Patent: December 9, 2014Assignee: Oscient Pharmaceuticals CorporationInventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josée Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil D. Pandit
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Publication number: 20120100146Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: ApplicationFiled: December 30, 2011Publication date: April 26, 2012Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josée Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil D. Pandit
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Patent number: 8105826Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: GrantFiled: March 23, 2007Date of Patent: January 31, 2012Assignee: Oscient Pharmaceuticals CorporationInventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josée Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil D. Pandit
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Publication number: 20100167285Abstract: The invention provides methods for evaluating irritable bowel disease (IBD), including Crohn Disease and Ulcerative Colitis, methods for determining a patient's susceptibility to developing an IBD, and methods for determining a patient's IBD genotype. The invention includes methods, polynucleotides, polypeptides, and antibodies relating to disclosed variants of, and polymorphisms in, the nel-like 1 precursor (NELL1), as well as the 5p13.1 locus, and other genes disclosed herein to be associated with IBD. Thus, the invention provides diagnostic and/or therapeutic targets for IBD, as well as diagnostic and therapeutic agents for IBD.Type: ApplicationFiled: March 26, 2008Publication date: July 1, 2010Inventors: Stefan Schreiber, Philip Rosenstiel, Andreas Ruether, Andre Franke, John Raelson, Randall D. Little, Tim Keith, Helene Fournier
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Publication number: 20090292002Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: ApplicationFiled: March 23, 2007Publication date: November 26, 2009Inventors: TIM KEITH, Randall D. Little, Paul Van Eerdewegh, Josee Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
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Patent number: 7285400Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: GrantFiled: December 10, 2003Date of Patent: October 23, 2007Assignees: Genome Therapeutics Corporation, Creighton UniversityInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
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Patent number: 7205146Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: GrantFiled: October 22, 2001Date of Patent: April 17, 2007Assignee: Oscient Pharmaceuticals CorporationInventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josée Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
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Patent number: 7151161Abstract: This invention relates to isolated nucleic acids comprising novel genes of a 20 cM region of human chromosome 11q13.3 and the proteins encoded by these genes. Expression vectors and host cells containing these genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.Type: GrantFiled: July 1, 2002Date of Patent: December 19, 2006Assignee: Oscient Pharmaceuticals CorporationInventors: John P. Carulli, Randall D. Little, Richard Del Mastro, Mark Osborne
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Publication number: 20040176582Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: ApplicationFiled: December 10, 2003Publication date: September 9, 2004Applicants: Genome Therapeutics Corporation, Creighton UniversityInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
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Patent number: 6780609Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: GrantFiled: April 5, 2000Date of Patent: August 24, 2004Assignee: Genome Therapeutics CorporationInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
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Patent number: 6770461Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: GrantFiled: April 5, 2000Date of Patent: August 3, 2004Assignees: Genome Therapeutics Corporation, Creighton University School of MedicineInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
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Publication number: 20040043021Abstract: This invention relates to ADAM and Interactor genes which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: ApplicationFiled: October 11, 2002Publication date: March 4, 2004Inventors: Tim Keith, Randall D. Little, Josee Dupuis, Paul Van Eerdewegh, Richard G. Del Mastro, Kristina Allen
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Publication number: 20040023215Abstract: This invention relates to genes identified from human chromosome 20p13-p12, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: ApplicationFiled: April 19, 2002Publication date: February 5, 2004Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josee Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
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Publication number: 20040002470Abstract: This invention relates to genes identified from human chromosome 20p13-p12, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.Type: ApplicationFiled: October 17, 2002Publication date: January 1, 2004Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josee Dupuis, Richard G. Del Mastro, Jason Simon, Kristin Allen, Sunil Pandit
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Publication number: 20030219793Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development and in focal adhesion signaling. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: ApplicationFiled: February 28, 2003Publication date: November 27, 2003Inventors: John P. Carulli, Robert R. Recker, Mark L. Johnson, Randall D. Little