Patents by Inventor Randall Davis
Randall Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210295969Abstract: A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.Type: ApplicationFiled: February 2, 2021Publication date: September 23, 2021Inventors: Randall Davis, Dana L. Penney
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Patent number: 11111534Abstract: Provided are methods of nucleic acid sample preparation for analysis, including analysis using nanopore sequencing applications. In particular provided are methods that allow for the creation of circular and linear DNA samples that contain asymmetric ends to ligate different and desired adaptors to the end of the sample, methods to create single nucleic acid molecules that automatically form concatemers for higher sequencing throughput; methods to create multiple copies (temperature dependent, multi-primed, open-fold replication) of one original nucleic acid sample, or to create single nucleic acid molecules containing multiple copies of more than one original nucleic acid sample (concatemerized samples) for improved accuracy and throughput are described; and methods for improved modified base calling.Type: GrantFiled: October 4, 2018Date of Patent: September 7, 2021Assignee: Roche Sequencing Solutions, inc.Inventors: Randall Davis, Michael Dorwart, Janine Mok
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Patent number: 11092589Abstract: A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.Type: GrantFiled: July 18, 2019Date of Patent: August 17, 2021Assignee: Roche Sequencing Solutions, Inc.Inventors: Roger J. A. Chen, Randall Davis
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Patent number: 11041845Abstract: Provided herein are methods and compositions for detecting and/or quantitating target analytes, including nucleic acids and polypeptides, using nanopore detectable barcodes.Type: GrantFiled: April 12, 2019Date of Patent: June 22, 2021Assignee: Roche Sequencing Solutions, Inc.Inventor: Randall Davis
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Patent number: 10943683Abstract: A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.Type: GrantFiled: January 10, 2018Date of Patent: March 9, 2021Assignees: Massachusetts Institute of Technology, Lahey Clinic Foundation Inc.Inventors: Randall Davis, Dana Penney
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Publication number: 20210041732Abstract: According to one implementation, a dual-mode augmented reality and virtual reality viewer (AR/VR viewer) includes a device configured to provide AR and VR effects, the device including a display screen, a VR shield, and a transparency control unit coupled to the VR shield. The AR/VR viewer also includes a computing platform for generating the AR and VR effects communicatively coupled to the device. The display screen has a user facing first surface for receiving the AR and VR effects, and a second surface opposite the user facing first surface. The display screen or a transmissive layer adjoining the display screen is configured to have a variable transparency. The VR shield is configured to be one of substantially transparent in an AR mode and substantially opaque in a VR mode under the control of the transparency control unit.Type: ApplicationFiled: October 27, 2020Publication date: February 11, 2021Inventors: Randall Davis, Nathan D. Nocon
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Patent number: 10859861Abstract: According to one implementation, a dual-mode augmented reality and virtual reality viewer (AR/VR viewer) includes a device configured to provide AR and VR effects, the device including a display screen, a VR shield, and a transparency control unit coupled to the VR shield. The AR/VR viewer also includes a computing platform for generating the AR and VR effects communicatively coupled to the device. The display screen has a user facing first surface for receiving the AR and VR effects, and a second surface opposite the user facing first surface. The display screen or a transmissive layer adjoining the display screen is configured to have a variable transparency. The VR shield is configured to be one of substantially transparent in an AR mode and substantially opaque in a VR mode under the control of the transparency control unit.Type: GrantFiled: December 3, 2018Date of Patent: December 8, 2020Assignee: Disney Enterprises, Inc.Inventors: Randall Davis, Nathan Nocon
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Publication number: 20200377944Abstract: This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.Type: ApplicationFiled: June 15, 2020Publication date: December 3, 2020Inventors: Randall Davis, Carl Fuller
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Patent number: 10822650Abstract: This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.Type: GrantFiled: March 27, 2017Date of Patent: November 3, 2020Assignee: Roche Sequencing Solutions, Inc.Inventors: Randall Davis, Roger Chen, Arkadiusz Bibillo, Daniel Korenblum
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Publication number: 20200337627Abstract: A method of determining a cognitive assessment for a subject includes receiving input position data associated with input provided by the subject during a time that the subject is responding to a cognitive test, receiving gaze position data associated with a gaze of the subject during the time that the subject is responding to the cognitive test, and determining a cognitive assessment for the subject based at least in part on the input position data and the gaze position data.Type: ApplicationFiled: April 27, 2020Publication date: October 29, 2020Inventors: Dana L. Penney, Randall Davis
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Publication number: 20200308641Abstract: This disclosure provides systems and methods for molecular identification and polymer (e.g., nucleic acid) sequencing using nanopores. The polymer may be passed through or in proximity to the nanopore and various subunits of the polymer may affect the current flowing through the nanopore. The various subunits may be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. In some cases, the polymerization of tagged nucleotides presents tag molecules to the nanopore that can be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. Also provided herein are systems and methods for sequencing both the sense and anti-sense strand of a double stranded nucleic acid molecule with a nanopore and methods for using ribonucleic acid (RNA) speed bump molecules to slow the passage of a nucleic acid molecule through or in proximity to a nanopore.Type: ApplicationFiled: April 17, 2020Publication date: October 1, 2020Applicant: Roche Sequencing Solutions, Inc.Inventors: Randall Davis, Roger Chen
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Publication number: 20200174298Abstract: According to one implementation, a dual-mode augmented reality and virtual reality viewer (AR/VR viewer) includes a device configured to provide AR and VR effects, the device including a display screen, a VR shield, and a transparency control unit coupled to the VR shield. The AR/VR viewer also includes a computing platform for generating the AR and VR effects communicatively coupled to the device. The display screen has a user facing first surface for receiving the AR and VR effects, and a second surface opposite the user facing first surface. The display screen or a transmissive layer adjoining the display screen is configured to have a variable transparency. The VR shield is configured to be one of substantially transparent in an AR mode and substantially opaque in a VR mode under the control of the transparency control unit.Type: ApplicationFiled: December 3, 2018Publication date: June 4, 2020Inventors: Randall Davis, Nathan Nocon
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Patent number: 10662471Abstract: This disclosure provides systems and methods for molecular identification and polymer (e.g., nucleic acid) sequencing using nanopores. The polymer may be passed through or in proximity to the nanopore and various subunits of the polymer may affect the current flowing through the nanopore. The various subunits may be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. In some cases, the polymerization of tagged nucleotides presents tag molecules to the nanopore that can be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. Also provided herein are systems and methods for sequencing both the sense and anti-sense strand of a double stranded nucleic acid molecule with a nanopore and methods for using ribonucleic acid (RNA) speed bump molecules to slow the passage of a nucleic acid molecule through or in proximity to a nanopore.Type: GrantFiled: September 13, 2017Date of Patent: May 26, 2020Assignee: Roche Sequencing Solutions, Inc.Inventors: Randall Davis, Roger Chen
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Publication number: 20190382327Abstract: Apparatuses and methods for producing crystalline materials from plant extracts are described herein. In one example, an apparatus for producing crystalline material from plant extract can include a vessel comprising an inner volume configured to receive a plant extract. The apparatus can include a desiccant chamber fluidly connected to the vessel. The desiccant chamber can house a desiccant material. The desiccant material can absorb water vapor from the plant extract and thereby promote growth of crystalline material.Type: ApplicationFiled: June 18, 2019Publication date: December 19, 2019Inventors: Jacqueline McGrane, Randall Davis
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Publication number: 20190367977Abstract: Described herein are methods and devices for capturing and determining the identity of molecules using nanopores. The molecules can be counted, sorted and/or binned rapidly in a parallel manner using a large number of nanopores (e.g., 132,000 nanopores reading 180 million molecules in 1 hour). This fast capture and reading of a molecule can be used to capture probe molecules or other molecules that have been generated to represent an original, hard to detect molecule or portions of an original molecule. Precise counting of sample molecules or surrogates for sample molecules can occur. The methods and devices described herein can, among other things, replace flow cytometers and other counting instruments (e.g., while providing increased precision and throughput relative to a flow cytometer).Type: ApplicationFiled: August 20, 2019Publication date: December 5, 2019Applicant: GENIA TECHNOLOGIES, INC.Inventor: Randall Davis
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Publication number: 20190369081Abstract: A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.Type: ApplicationFiled: July 18, 2019Publication date: December 5, 2019Inventors: Roger J.A. Chen, Randall Davis
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Publication number: 20190292591Abstract: Systems and methods of polynucleotide sequencing are provided. Systems and methods optimize control, speed, movement, and/or translocation of a sample (e.g., a polynucleotide) within, through, or at least partially through a nanopore or a type of protein or mutant protein in order to accumulate sufficient time and current blocking information to identify contiguous nucleotides or plurality of nucleotides in a single-stranded area of a polynucleotide.Type: ApplicationFiled: March 12, 2019Publication date: September 26, 2019Applicants: GENIA TECHNOLOGIES, INC., LIFE TECHNOLOGIES CORPORATIONInventors: Timothy GEISER, Randall DAVIS, Roger CHEN
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Patent number: 10421995Abstract: Described herein are methods and devices for capturing and determining the identity of molecules using nanopores. The molecules can be counted, sorted and/or binned rapidly in a parallel manner using a large number of nanopores (e.g., 132,000 nanopores reading 180 million molecules in 1 hour). This fast capture and reading of a molecule can be used to capture probe molecules or other molecules that have been generated to represent an original, hard to detect molecule or portions of an original molecule. Precise counting of sample molecules or surrogates for sample molecules can occur. The methods and devices described herein can, among other things, replace flow cytometers and other counting instruments (e.g., while providing increased precision and throughput relative to a flow cytometer).Type: GrantFiled: October 23, 2014Date of Patent: September 24, 2019Assignee: GENIA TECHNOLOGIES, INC.Inventor: Randall Davis
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Publication number: 20190288978Abstract: There is provided a system and method for user generated gameplay in chat. The system including a memory storing a text and multimedia messaging software application, and a processor configured to execute the text and multimedia messaging software application to initiate a message exchange session with a remote mobile device, in response to a request received from a user of the mobile device, the message exchange session displaying a user interface for exchanging text and multimedia messages, provide a plurality of games for selection by the user to be played during the message exchange session and within the user interface for exchanging text and multimedia messages, receive a selection of one of the plurality of games by the user after initiating the message exchange session, and initiate the one of the plurality of games for playing within the user interface for exchanging text and multimedia messages.Type: ApplicationFiled: June 6, 2019Publication date: September 19, 2019Inventors: John Crocker, Randall Davis, Orrin Shively, Christopher W. Heatherly, James Molinets
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Publication number: 20190276887Abstract: This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.Type: ApplicationFiled: March 25, 2019Publication date: September 12, 2019Applicants: The Trustees of Columbia University in the City of New York, Genia Technologies, Inc.Inventors: Carl W. FULLER, Shiv KUMAR, Jingyue JU, Randall DAVIS, Roger CHEN