Abstract: An Optical Imaging Device of Retinal Function has been developed to detect changes in reflectance of near infrared light from the retina of human subjects in response to visual activation of the retina by a pattern stimulus. The measured changes in reflectance correspond in time to the onset and offset of the visual stimulus in the portion of the retina being stimulated. Any changes in reflectance can be measured by interrogating the retina with a light source. The light source may be presented to the retina via the cornea and pupil or through other tissues in and around the eye. Different wavelengths of interrogating light may be used to interrogate various layers of the retina. Additionally, various novel patterns and methods of stimulation have been developed for use with the imaging device and methods.

Abstract: An Optical Imaging Device of Retinal Function has been developed to detect changes in reflectance of near infrared light from the retina of human subjects in response to visual activation of the retina by a pattern stimulus. The measured changes in reflectance correspond in time to the onset and offset of the visual stimulus in the portion of the retina being stimulated. Any changes in reflectance can be measured by interrogating the retina with a light source. The light source may be presented to the retina via the cornea and pupil or through other tissues in and around the eye. Different wavelengths of interrogating light may be used to interrogate various layers of the retina. Additionally, various novel patterns and methods of stimulation have been developed for use with the imaging device and methods.

Abstract: An automated system and method for determining pupillary threshold response is described. The system achieves the determination of pupillary threshold levels through the measurement of supra-threshold responses at varying light intensities, which measured values are processed by a non-linear regression routine to approximate threshold response. The system takes supra-threshold measurements by means of a computerized pupillometer which is linked to an automated perimeter. The measurements are sequentially taken at varied light intensities which are reiteratively selected in response to the comparison between responses that have been previously measured during the test and a pre-stored response curve of expected values. The measured values are then processed by a non-linear regression routine to indirectly generate an estimated threshold level.