Patents by Inventor Randy Michael Berka

Randy Michael Berka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
    Publication number: 20030224482
    Abstract: Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence.
    Type: Application
    Filed: February 6, 2003
    Publication date: December 4, 2003
    Applicant: Genencor International, Inc.
    Inventors: Randy Michael Berka, Daniel Cullen, Gregory Lawrence Gray, Kirk James Hayenga, Virgil Bryan Lawlis
  • Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
    Publication number: 20030044955
    Abstract: Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence.
    Type: Application
    Filed: March 20, 2002
    Publication date: March 6, 2003
    Applicant: Genencor International, Inc.
    Inventors: Randy Michael Berka, Daniel Cullen, Gregory Lawrence Gray, Kirk James Hayenga, Virgil Bryan Lawlis
  • Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
    Patent number: 6379928
    Abstract: Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: April 30, 2002
    Assignee: Genencor International, Inc.
    Inventors: Randy Michael Berka, Daniel Cullen, Gregory Lawrence Gray, Kirk James Hayenga, Virgil Bryan Lawlis
  • Heterologous polypeptides expressed in filamentous fungi, process for making same, and vectors for making same
    Patent number: 6171817
    Abstract: Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: January 9, 2001
    Assignee: Genencor International, Inc.
    Inventors: Randy Michael Berka, Daniel Cullen, Gregory Lawrence Gray, Kirk James Hayenga, Virgil Bryan Lawlis
  • Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
    Patent number: 6103490
    Abstract: Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: August 15, 2000
    Assignee: Genencor International, Inc.
    Inventors: Randy Michael Berka, Daniel Cullen, Gregory Lawrence Gray, Kirk James Hayenga, Virgil Bryan Lawlis
  • Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
    Patent number: 6004785
    Abstract: Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 21, 1999
    Assignee: Genencor International Inc.
    Inventors: Randy Michael Berka, Daniel Cullen, Gregory Lawrence Gray, Kirk James Hayenga, Virgil Bryan Lawlis
  • Purified myceliophthora laccases and nucleic acids encoding same
    Patent number: 5981243
    Abstract: The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Myceliophthora laccase, and the laccase proteins encoded thereby.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: November 9, 1999
    Inventors: Randy Michael Berka, Stephen H. Brown, Feng Xu, Palle Schneider, Karen M. Oxenb.o slashed.ll, Dorrit A. Aaslyng
  • Purified scytalidium laccases and nucleic acids encoding same
    Patent number: 5843745
    Abstract: The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Scytalidium laccase, and the laccase proteins encoded thereby.
    Type: Grant
    Filed: October 4, 1995
    Date of Patent: December 1, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Randy Michael Berka, Sheryl Ann Thompson, Feng Xu
  • Purified Myceliophthora laccases and nucleic acids encoding same
    Patent number: 5795760
    Abstract: The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Myceliophthora laccase, and the laccase proteins encoded thereby.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: August 18, 1998
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Randy Michael Berka, Stephen H. Brown, Feng Xu, Palle Schneider, Karen M. Oxenb.o slashed.ll, Dorrit A. Aaslyng
  • Purified scytalidium laccases and nucleic acids encoding same
    Patent number: 5750388
    Abstract: The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Scytalidium laccase, and the laccase proteins encoded thereby.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: May 12, 1998
    Assignee: Novo Nordish Bio Tech, Inc
    Inventors: Randy Michael Berka, Sheryl Ann Thompson, Feng Xu
  • Aspergillus expression system
    Patent number: 5667990
    Abstract: The present invention relates to a novel expression system in which A. japonicus-type species are used as host cells for expression of heterologous proteins.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 16, 1997
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Randy Michael Berka, Wendy Yoder, Shinobu Takagi, Karuppan Chettier Boominathan