Abstract: The present invention pertains to a new nanoparticle-like delivery system for intracellular delivery of cargo molecules such as nucleic acids, ribonucleoproteins and extracellular vesicles.

Abstract: Processes and systems related to solid phase peptide synthesis are described. The processes include a flow-through process comprising cyclic addition of amino acids to a column packed with resin, wherein each cycle includes the combination of the amino acids with one or more reagents to provide an activated amino acid mixture, and wherein heating is applied to the amino acid(s) before they are passed through the column and wherein the amino acids are re-circulated at least once over the column packed with resin. Systems for such processes are also described.

Abstract: The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.

Abstract: The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.

Abstract: A GPCR135/relaxin3 complex is described, which is useful as an assay reagent for screening for modulators of GPCR135 receptor activity.

Abstract: A GPCR135/relaxin3 complex is described, which is useful as an assay reagent for screening for modulators of GPCR135 receptor activity.

Abstract: A cylindrical bushing interposed between the primary support of a dental implant and a replica of the implant in order to electrically erode the primary support for a secure fit to the replica and hence the implant without causing any electrical erosion to the replica.

Abstract: A releasable holding element for the attachment of a primary support bar of a full or partial dental prosthesis to the overlaid secondary support bar and artificial teeth, the releasable holding element in the form of a latch pin, elongated in shape, being utilized as the actual electrode for forming the channel for its ultimate receipt in the primary and secondary support bars, the receiving channel forming an acute angle with the axis of the primary support bar and secondary bar in order to provide greater contact area between the releasable holding element and the primary bar and secondary bar.

Abstract: A support structure for a dental implant appliance secured to the alveolar bone, the support structure shaped to the curvilinear contour of the portion of the jaw receiving the dental appliance, the support structure segmented by transverse cuts, each transverse cut having a divergent recess on opposing sides thereof for receipt of a complimentary recess plug in cooperation with investment solder to reattach the segments after fitting.

Abstract: A process for fabricating a partial denture or bridge appliance securable to an abutment tooth or abutment teeth having crowns or copings thereon, the partial denture or bridge appliance in snap fit secure relationship with the crown or coping on the abutment tooth or teeth, the snap-fit fitting achieved by electrical erosion methods in order to eliminate any undue stress or strain on the abutment tooth or teeth so as to prevent their eventual loosening or loss.

Abstract: A fixed, removable dental implant having a precision cast support structure secured to the alveolar bone and a female supra structure conforming in shape to the precision cast support bar removably mounted and secured to the precision cast support bar, the supra structure having the acrylic prosthesis secured thereto, the precision cast support bar and female supra structure having conforming configurations achieved by electrical erosion methods to provide the patient with the confidence and security of a fixed dental prosthesis yet permitting the patient to remove the supra structure and acrylic prosthesis for cleaning without the necessity of a dental visit.

Abstract: A fixed, removable dental implant having a precision cast support structure secured to the alveolar bone and a female supra structure conforming in shape to the precision cast support bar removably mounted and secured to the precision cast support bar by means of a locking mechanism in cooperation with a series of guide pins, the supra structure having the acrylic prosthesis secured thereto, the precision cast support bar and female supra structure having conforming configurations achieved by electrical erosion methods to provide the patient with the confidence and security of a fixed dental prosthesis yet permitting the patient to remove the supra structure and acrylic prosthesis for cleaning without the necessity of a dental visit.