Patents by Inventor Raouf A. Guirguis
Raouf A. Guirguis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5358690Abstract: An apparatus for collecting fluids and holding samples taken from the fluid for qualitative and quantitative testing. The apparatus comprises a tubular container open at both ends with a quantitative test storage unit removably secured to one of said tubular container ends. The quantitative test storage unit has an open end, a cytology membrane mounted in the storage unit and a retaining rib. A shuttle assembly is slidably mounted in the tubular container comprising a cylindrical hollow piston defining a chamber, a thumb cover covering one end of the piston and a fluid flow aperture formed in the piston and a qualitative sample container assembly removably secured to the piston. The qualitative sample container assembly comprises a clip on membrane assembly including a membrane containing immobilized antibodies and a filter housing mounted to the clip on membrane assembly.Type: GrantFiled: December 30, 1991Date of Patent: October 25, 1994Assignee: LaMina, Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5301685Abstract: The present invention is directed toward a cytology collection apparatus and a method for preparing a uniform monolayer of cells. The apparatus allows the rapid preparation from body fluids of a cytology monolayer with very few overlapping cells and with fewer contaminants than prior devices. The apparatus is in the form of an openable cell collection container which houses a filter for collection of cells when body fluid passes therethrough.Type: GrantFiled: July 28, 1992Date of Patent: April 12, 1994Inventor: Raouf A. Guirguis
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Patent number: 5244815Abstract: A method and device for testing for the presence of substances such as drugs in body fluids while simultaneously positively identifying the test subject. The device comprises an absorbent pad and a membrane mounted to the absorbent pad containing a plurality of separated areas provided with different immobilized ligand having a specific receptor site for capture or rejection of specific antigens produced by different predetermined drugs.Type: GrantFiled: September 13, 1991Date of Patent: September 14, 1993Assignee: LaMina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5224489Abstract: The present invention is directed toward an apparatus and a method which can use immunoassay in sample treatment apparatus for diagnostic and testing purposes of urine by concentrating specific urine antigen in a small volume area and concentrating the urinary sediments in a separate small volume area. Urine is transported through the tubular container under pressure to flow through the sample container which screens off the urinary sediments and the beads so that antigens carried in the urine are collected and concentrated on the beads.Type: GrantFiled: August 23, 1991Date of Patent: July 6, 1993Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5215102Abstract: A fluid testing apparatus comprising a housing, a structure defining a well located in housing, a container rotatably mounted in the housing and positioned over the well. The container has a housing with a fluid flow aperture in which a filter is mounted to filter fluid passing therethrough into the well. A capillary ligand test assembly is secured to said container housing and comprises a capillary tube, a membrane strip mounted in the capillary tube and absorbent material mounted in the capillary tube adjacent the membrane strip. The membrane strip is divided into a testing zone and a control zone provided with designated ligands to capture other specific predetermined ligands.Type: GrantFiled: October 25, 1991Date of Patent: June 1, 1993Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5139031Abstract: The present invention is directed towards an apparatus and a method which can use immunoassay in sample treatment apparatus for diagnostic and testing purposes of dialysis fluid or urine by concentrating the urinary sediments on a first membrane and concentrating bacteria on a second membrane. Urine is transported through the tubular container under pressure to flow through the sample container which separately screens off the urinary sediments and the bacteria for collection and testing.Type: GrantFiled: April 8, 1991Date of Patent: August 18, 1992Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5137031Abstract: An apparatus and method for testing molecular specimens in a biological fluid and collecting cellular components from the fluid comprising a container housing defining a chamber with a fluid inlet and outlet. A filter membrane is mounted in the housing chamber dividing the chamber into two compartments with the filter membrane allowing a biological fluid flow and antigens carried therein to flow therethrough into one compartment while concentrating the cellular components in another compartment by preventing the flow therethrough. Chromatography beads are contained in a compartment opposing the cellular component compartment and a cellular component collection cup with an inlet and outlet is removably mounted to the container housing in fluid communication with the compartment opposite the chromatography bead compartment. A cytology membrane is mounted in the collection cup to prevent passage of cellular components when biological fluid is being discharged from the collection cup.Type: GrantFiled: August 15, 1990Date of Patent: August 11, 1992Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5133363Abstract: An apparatus for collecting and testing multiple biological markers comprising a tubular compartmentalized container holding covalently bound antigen beads and correlating anti-antibody beads contained in separated compartments. The biological fluid, namely urine, is collected in the tubular container and is forced to flow through the separated compartment of the compartmentalized container so that predetermined ligands become attached to the bead ligands to obtain a plurality of biological markers.Type: GrantFiled: August 21, 1990Date of Patent: July 28, 1992Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5077012Abstract: An apparatus for collecting biological fluids and holding samples taken from a biological fluid for qualitative and quantitative testing. The apparatus comprises a tubular container open at both ends with a quantitative test storage unit removably secured to one of said tubular container ends. The quantitative test storage unit has an open end, a cytology membrane mounted in the storage unit and a retaining rib. A shuttle assembly is slidably mounted in the tubular container comprising a cylindrical hollow piston defining a chamber, a thumb cover covering one end of the piston and a fluid flow aperture formed in the piston and a qualitative sample container assembly removable secured to the piston. The qualitative sample container assembly comprises a clip on membrane assembly including a membrane containing immobilized antibodies and a filter housing mounted to the clip on membrane asssembly.Type: GrantFiled: April 9, 1990Date of Patent: December 31, 1991Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5042502Abstract: The present invention is directed toward an apparatus and a method which can use immunoassay in sample treatment apparatus for diagnostic and testing purposes of urine by concentrating specific urine antigen in a small volume area and concentrating the urinary sediments in a separate small volume area. Urine is transported through the tubular container under pressure to flow through the sample container which screens off the urinary sediments and the beads so that antigens carried in the urine are collected and concentrated on the beads.Type: GrantFiled: July 18, 1990Date of Patent: August 27, 1991Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5038793Abstract: An apparatus for testing biological molecular indicators in blood comprising a tubular container, and a sample compartmentalized removable container holding a membrane with immobilized ligands. Blood is collected in the tubular container under pressure to flow through the sample compartmentalized container which screens off the blood cells so that specific ligands carried by the blood can be captured by the immobilized ligands on the membrane.Type: GrantFiled: January 19, 1990Date of Patent: August 13, 1991Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5024237Abstract: An apparatus for collecting and testing biological molecular indicators in a biological fluid comprising a tubular container having an open end, and a compartmentalized container holding beads with immobilized ligands. The biological fluid namely urine is collected in the tubular container and is forced to flow through the sample compartmentalized container so that predetermined molecules of opposite matching charges to immobilized ligands become attached to the bead ligands for easy color testing to obtain specified medical tests.Type: GrantFiled: June 21, 1989Date of Patent: June 18, 1991Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5024238Abstract: An apparatus for testing biological molecular indicators in blood comprising a tubular container, and a sample compartmentalized container holding labelled ligands and beads with immobilized ligands. Blood is collected in the tubular container under pressure to flow through the sample compartmentalized container which screens off the red blood cells so that enzymes of the labelled ligands are carried by the blood fluid to a reactant solution which is colored by specific labelled ligands to indicate the presence of specific ligands.Type: GrantFiled: September 18, 1989Date of Patent: June 18, 1991Assignee: Cancer Diagnostics, Inc.Inventor: Raouf A. Guirguis
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Patent number: 5022411Abstract: An apparatus for testing biological molecular indicators in urine comprising a tubular container with a plunger assembly and associated testing assembly. Urine is collected in the tubular container mixed with labelled antibodies and is caused by the plunger assembly to flow against a testing surface provided with immobilized antibodies which capture antigens complexed with labelled antibodies. The enzymes of the labelled antibodies are colored by a reactant solution to indicate the presence or absence of specific antigens in the tested urine.Type: GrantFiled: November 22, 1989Date of Patent: June 11, 1991Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5016644Abstract: A method for testing for biological molecular indicators in urine. Urine is transported through a sample container under pressure to flow through the sample container so that antigens in the urine are collected and bound on antibodies immobilized on the beads to form antigen-antibody complex. The beads are washed to remove cell debris and charged molecules and a specific prelabelled antibody solution is passed through the sample container with the prelabelled antibodies attaching to a receptor site on the captured antigen to form an antibody-antigen-prelabelled antibody sandwich complex. This sandwich complex is washed to remove cell debris and charged molecules and mixed with a color reagent solution which reacts with the prelabelled antibody to produce an color indicating the presence of a specific cancer antigen.Type: GrantFiled: September 25, 1989Date of Patent: May 21, 1991Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 5003988Abstract: An apparatus for collecting and testing multiple biological markers comprising a tubular compartmentalized container holding covalently bound antigen beads and correlating anti-antibody beads contained in separated compartments. The biological fluid, namely urine, is collected in the tubular container and is forced to flow through the separated compartment of the compartmentalized container so that predetermined ligands become attached to the bead ligands to obtain a plurality of biological markers.Type: GrantFiled: August 22, 1989Date of Patent: April 2, 1991Assignee: La Mina Ltd.Inventor: Raouf A. Guirguis
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Patent number: 4961432Abstract: An apparatus for collecting biological fluids and handling the same into a sample for testing comprising a tubular container having open ends, one of which is removably secured to a collection storage unit. A shuttle assembly constructed of a cylindrical hollow piston defining a chamber, a top cover covering one end of said piston and a second cover with an aperture and a connector covering the second end of the piston is slidably mounted in the tubular container. An "O" ring is mounted on the exterior surface of the piston to form a fluid tight seal between the "O" ring and the interior surface of the tubular container with the connector being removably secured to a resin/sample container so that movement of the piston in the tubular container carries the resin/sample container into the collection storage unit and forces fluid collected in the tubular container to flow through the resin/sample container.Type: GrantFiled: January 10, 1989Date of Patent: October 9, 1990Assignee: Cancer Diagnostics, Inc.Inventor: Raouf A. Guirguis
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Patent number: 4960130Abstract: An apparatus for collecting biological fluids and handling the same into a sample for testing comprising a tubular container having open ends, one of which is removably secured to a collection storage unit. A shuttle assembly constructed of a cylindrical hollow piston defining a chamber, a top cover covering one end of said piston and a second cover with an aperture and a connector covering the second end of the piston is slidably mounted in the tubular container. An "O" ring is mounted on the exterior surface of the piston to form a fluid tight seal between the "O" ring and the interior surface of the tubular container with the connector being removably secured to a resin/sample container so that movement of the piston in the tubular container carries the resin/sample container into the collection storage unit and forces fluid collected in the tubular container to flow through the resin/sample container.Type: GrantFiled: November 14, 1989Date of Patent: October 2, 1990Assignee: Cancer Diagnostics, Inc.Inventor: Raouf A. Guirguis
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Patent number: 4953561Abstract: An apparatus for testing biological molecular indicators in urine comprising a tubular container, and a sample container holding beads with immobilized ligands. Urine is transported through the tubular container under pressure to flow through the sample container which screens off the antibodies so that antigens of the carried by the urine fluid are collected and concentrated on the beads.Type: GrantFiled: September 22, 1989Date of Patent: September 4, 1990Assignee: Cancer Diagnostics, Inc.Inventor: Raouf A. Guirguis
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Patent number: 4912057Abstract: A chemotaxis assay instrument comprising a plate assembly with a bottom plate, a gasket seal mounted to the bottom plate and an intermediate plate mounted on the other side of the gasket seal and spaced by the gasket seal from the bottom plate. The intermediate plate defines a plurality of wells to hold a sample and a filter membrane is mounted on the intermediate plate. A second intermediate plate is spaced from the first intermediate plate by the filter membrane and second gasket seal is mounted on the other side of the second intermediate plate with a top plate mounted on said second gasket seal and spaced by the second gasket seal from the second intermediate plate, the plate assembly being held together by fasteners in a sealed relationship.Type: GrantFiled: June 13, 1989Date of Patent: March 27, 1990Assignee: Cancer Diagnostics, Inc.Inventors: Raouf A. Guirguis, Richard H. Goodwin