Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.

Abstract: An impact absorption assembly for a seat back is provided having a deformation zone as least partially disposed above a top surface of a seat back structure. The deformation zone deforms plastically upon an impact from a rearward direction.

Abstract: The invention concerns a high speed writing system and a high speed writing device with special menu selection for entering text by means of a pen and a touch-screen. This method of entering text is suitable for desktop PCs, laptop PCs, palmtop PCs, mobile phones (for SMS, WAP and e-mail), watches and other electronic devices. Significantly higher writing efficiency than on a QWERTY keyboard is reached with little investment in practicing time. The monitor screen features a key section with all consonants of the alphabet, as well as one vowel key distinguished by its arrangement and function.

Abstract: The invention relates to a rapid input device comprising at least one input means, at least on input-capture unit and a computer. The input means defines at least one point by means of the spacial position thereof and the co-ordinates thereof are converted into electric signals in the at least one input capture unit and form at least one amount of data during a period of time from the points and the input thereof. The input capture unit is connected to the computer. Said computer is provided with means for processing the at least one amount of data. The input capture unit is connected to the computer in a wireless manner or by means of a cable. Said rapid input device is mobile and compact. The invention also relates to a method for operating said device and the uses thereof in pad devices, general computer work and rehabilitation.

Abstract: The invention concerns a high speed writing system and a high speed writing device with special menu selection for entering text by means of a pen and a touch-screen. This method of entering text is suitable for desktop PCs, laptop PCs, palmtop PCs, mobile phones (for SMS, WAP and e-mail), watches and other electronic devices. Significantly higher writing efficiency than on a QWERTY keyboard is reached with little investment in practicing time.