Patents by Inventor Raphael Mannino
Raphael Mannino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964019Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: GrantFiled: June 18, 2020Date of Patent: April 23, 2024Assignees: Rutgers, The State University of New Jersey, Matinas BioPharma Nanotechnologies, Inc.Inventors: Raphael Mannino, Ruying Lu
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Publication number: 20210038722Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: ApplicationFiled: June 18, 2020Publication date: February 11, 2021Inventors: Raphael MANNINO, Ruying LU
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Patent number: 10716860Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: GrantFiled: November 13, 2017Date of Patent: July 21, 2020Assignees: Matinas BioPharma Nanotechnologies, Inc., Rutgers, The State University of New JerseyInventors: Raphael Mannino, Ruying Lu
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Publication number: 20180185491Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: ApplicationFiled: November 13, 2017Publication date: July 5, 2018Inventors: Raphael Mannino, Ruying Lu
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Patent number: 9775907Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: GrantFiled: January 29, 2015Date of Patent: October 3, 2017Assignee: MATINAS BIOPHARMA NANOTECHNOLOGIES, INC.Inventors: Raphael Mannino, Ruying Lu
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Patent number: 9370572Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: GrantFiled: January 29, 2015Date of Patent: June 21, 2016Assignee: AQUARIUS BIOTECHNOLOGIES, INCInventors: Raphael Mannino, Ruying Lu
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Publication number: 20150297725Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: ApplicationFiled: July 30, 2013Publication date: October 22, 2015Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, AQUARIUS BIOTECHNOLOGIES, INC.Inventors: RAPHAEL MANNINO, RUYING LU
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Publication number: 20150147380Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: ApplicationFiled: January 29, 2015Publication date: May 28, 2015Inventors: RAPHAEL MANNINO, RUYING LU
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Publication number: 20150140074Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.Type: ApplicationFiled: January 29, 2015Publication date: May 21, 2015Inventors: RAPHAEL MANNINO, RUYING LU
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Publication number: 20140220108Abstract: The present invention provides, in part, cochleate compositions and methods for making and using same.Type: ApplicationFiled: May 4, 2012Publication date: August 7, 2014Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, COORDINATED PROGRAM DEVELOPMENT, LLCInventors: Ruying Lu, Raphael Mannino
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Publication number: 20080009457Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: January 11, 2007Publication date: January 10, 2008Applicant: BioDelivery Sciences International, Inc.Inventors: Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore
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Publication number: 20070237814Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: ApplicationFiled: January 11, 2007Publication date: October 11, 2007Applicants: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New JerseyInventors: Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu
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Publication number: 20060029656Abstract: Disclosed are cochleates and cochleate compositions that associated with an replacement enzyme component and/or a plasmid component that encodes a replacement enzyme. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of replacement enzymes and/or plasmids encoding the same in a variety of dosage forms.Type: ApplicationFiled: February 3, 2005Publication date: February 9, 2006Applicant: BioDelivery Sciences International, Inc.Inventors: Francis O'Donnell, Raphael Mannino, Susan Gould-Fogerite
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Publication number: 20060019870Abstract: Disclosed herein are cochleates and cochleate compositions associated with an apoprotein component and/or a plasmid component that encodes an apoprotein. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of apoproteins and/or plasmids encoding the same in a variety of dosage forms.Type: ApplicationFiled: January 28, 2005Publication date: January 26, 2006Inventors: Francis O'Donnell, Susan Gould-Fogerite, Raphael Mannino
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Publication number: 20050186265Abstract: A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.Type: ApplicationFiled: January 18, 2005Publication date: August 25, 2005Applicant: University of Medicine and Dentistry of New JerseyInventors: Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael Mannino
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Publication number: 20050129661Abstract: An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates for the proteins. Upon contact with a lipid bilayer of a target cell, the cochleate vector structure delivers one or more of the therapeutic nucleotide sequences and one or more proteins to the interior of the target cell. Upon entry into the cell, the proteins facilitate the integration of the therapeutic nucleotide sequence into the genome of the host cell.Type: ApplicationFiled: January 24, 2005Publication date: June 16, 2005Applicants: University of Medicine and Dentistry of New Jersey, University of MarylandInventors: David Margolis, Susan Gould-Fogerite, Raphael Mannino
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Publication number: 20050013855Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.Type: ApplicationFiled: April 9, 2004Publication date: January 20, 2005Applicants: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New JerseyInventors: Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore
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Publication number: 20050013854Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.Type: ApplicationFiled: April 9, 2004Publication date: January 20, 2005Inventors: Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu
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Publication number: 20050008686Abstract: The present invention provides novel fragile nutrient cochleates that generally include one or more encochleated fragile nutrients, e.g., beta carotene, and methods for making the same. Also provided are methods for the use and administration of the fragile nutrient cochleates of the invention.Type: ApplicationFiled: January 15, 2004Publication date: January 13, 2005Inventors: Raphael Mannino, Sara Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Feng Tan
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Patent number: 6153217Abstract: A process for producing a small-sized, lipid-based cochleate is described. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structure by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca.sup.2+ or Zn.sup.2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing pharmaceutical agents or biologically relevant molecules. Small-sized cochleates may be administered orally or through the mucosa to obtain an effective method of treatment.Type: GrantFiled: January 22, 1999Date of Patent: November 28, 2000Assignees: Biodelivery Sciences, Inc., University of Medicine and Denistry of New JerseyInventors: Tuo Jin, Leila Zarif, Raphael Mannino