Patents by Inventor Raphael Ottenbrite

Raphael Ottenbrite has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tumor necrosis factor inhibitors
    Patent number: 9096607
    Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: August 4, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Mark I. Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiao
  • TUMOR NECROSIS FACTOR INHIBITORS
    Publication number: 20140256803
    Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.
    Type: Application
    Filed: May 16, 2014
    Publication date: September 11, 2014
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: MARK I. GREENE, RAMACHANDRAN MURALI, XIN CHENG, RAPHAEL OTTENBRITE, YINGXIN XIAO
  • Tumor necrosis factor inhibitors
    Patent number: 8765810
    Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: July 1, 2014
    Assignees: The Trustees Of The University Of Pennsylvania, Cephalon, Inc.
    Inventors: Mark I. Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiaio
  • Tumor necrosis factor inhibitors
    Patent number: 8318699
    Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: November 27, 2012
    Assignees: The Trustees Of The University Of Pennsylvania, Cephalon, Inc.
    Inventors: Mark I Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiao
  • Polymeric delivery agents and delivery agent compounds
    Patent number: 7727558
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: June 1, 2010
    Assignees: Emisphere Technologies, Inc., Virginia Commonwealth University
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John Smart, Richard Conticello, Raphael Ottenbrite
  • TUMOR NECROSIS FACTOR INHIBITORS
    Publication number: 20090221527
    Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.
    Type: Application
    Filed: January 31, 2006
    Publication date: September 3, 2009
    Applicants: CEPTION THERAPEUTICS, INC., TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Mark I. Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiao
  • POLYMERIC DELIVERY AGENTS AND DELIVERY AGENT COMPOUNDS
    Publication number: 20070141022
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: January 31, 2007
    Publication date: June 21, 2007
    Inventors: Sam Milstein, Eugene Barantsevitch, Nai Wang, Jun Liao, John Smart, Richard Conticello, Raphael Ottenbrite
  • ?-lactamase inhibitors and methods of use thereof
    Patent number: 7183267
    Abstract: The invention provides novel non-?-lactam inhibitors of ?-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be used with ?-lactam antibiotics to bacterial infection, particularly, ?-lactam-antibiotic-resistant bacterial infections. These compounds are also antibacterial agents by themselves. The invention further provides methods of using such compounds. Finally, the invention provides a pharmaceutical composition comprising these compounds.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: February 27, 2007
    Assignees: The Johns Hopkins University, Fulcrum Pharmaceuticals Inc.
    Inventors: Ernesto Freire, Patrick Ross, Yingxin Xiao, Raphael Ottenbrite, Irene Luque
  • Inhibitors of coronavirus protease and methods of use thereof
    Publication number: 20050267071
    Abstract: This invention provides organic boron-containing compounds, compositions thereof, and methods of using such compounds and compositions for inhibiting coronavirus protease(s) and for treating infections.
    Type: Application
    Filed: November 1, 2004
    Publication date: December 1, 2005
    Applicants: Fulcrum Pharmaceuticals, Inc., Johns Hopkins University
    Inventors: Ernesto Freire, Raphael Ottenbrite, Yingxin Xiao, Adrian Velazquez-Campoy, Stephanie Leavitt, Usman Bacha, Jennifer Barrila
  • Beta-lactamase inhibitors and methods of use thereof
    Publication number: 20050124580
    Abstract: The invention provides novel non-?-lactam inhibitors of ?-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be used with ?-lactam antibiotics to bacterial infection, particularly, ?-lactam-antibiotic-resistant bacterial infections. These compounds are also antibacterial agents by themselves. The invention further provides methods of using such compounds. Finally, the invention provides a pharmaceutical composition comprising these compounds.
    Type: Application
    Filed: June 10, 2004
    Publication date: June 9, 2005
    Applicant: Fulcrum Pharmaceuticals, Inc.
    Inventors: Ernesto Freire, Patrick Ross, Yingxin Xiao, Raphael Ottenbrite, Irene Luque