Patents by Inventor Rashi Iyer
Rashi Iyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10908149Abstract: Disclosed herein are embodiments of devices for managing fluid transport. In particular disclosed embodiments, the devices are used to manage fluid transport in reactor systems, such as bio-assessment systems, chemical synthesis reactors, and the like. The devices disclosed herein include fluid management devices, reservoir assemblies, valving systems, pumps, and combinations thereof. The devices disclosed herein are cost-efficient and user-friendly and can be implemented in a variety of reactor systems.Type: GrantFiled: September 24, 2015Date of Patent: February 2, 2021Assignee: Triad National Security, LLCInventors: Rashi Iyer, Pulak Nath, Jen-Huang Huang
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Patent number: 10634665Abstract: Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.Type: GrantFiled: September 24, 2015Date of Patent: April 28, 2020Assignees: Triad National Security, LLC, Vanderbilt UniversityInventors: Rashi Iyer, Jen-Huang Huang, Pulak Nath, Jennifer Harris, John P. Wikswo, Jr.
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Patent number: 10564148Abstract: Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are contacted with a disclosed culture medium under conditions sufficient to support growth, viability, and/or function of the cell types, tissues, and/or organs. The disclosed media can be used in methods of culturing multiple cell types, and in some examples, is used in a platform device including one or more organ devices, for example, by circulating the medium through the one or more organ devices in the platform.Type: GrantFiled: September 24, 2015Date of Patent: February 18, 2020Assignees: Triad National Security, LLC, CFD Research CorporationInventors: Rashi Iyer, Jennifer F. Harris, Jen-Huang Huang, Pulak Nath, Andrzej Przekwas
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Publication number: 20170363616Abstract: Disclosed herein are devices including a substrate, one or more regions of electrically active material, and optionally at least one electrode. Also disclosed herein are devices or systems including a substrate, one or more regions of electrically active material including muscle cells and neuronal cells, and optionally at least one electrode. In some embodiments, the muscle cells and neuronal cells form one or more neuromuscular junctions at defined locations on the electrically active material. Also disclosed are methods of using the devices and systems for analyzing the effect of compounds on neuronal cell, muscle cell and/or neuromuscular junction activity.Type: ApplicationFiled: November 24, 2015Publication date: December 21, 2017Applicant: Los Alamos National Security, LLCInventors: Rashi Iyer, Piyush Bajaj
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Publication number: 20170307594Abstract: Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.Type: ApplicationFiled: September 24, 2015Publication date: October 26, 2017Applicant: Los Alamos National Security, LLCInventors: Rashi Iyer, Jen-Huang Huang, Pulak Nath, Jennifer Harris
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Publication number: 20170291173Abstract: Disclosed herein are embodiments of devices for managing fluid transport. In particular disclosed embodiments, the devices are used to manage fluid transport in reactor systems, such as bio-assessment systems, chemical synthesis reactors, and the like. The devices disclosed herein include fluid management devices, reservoir assemblies, valving systems, pumps, and combinations thereof. The devices disclosed herein are cost-efficient and user-friendly and can be implemented in a variety of reactor systems.Type: ApplicationFiled: September 24, 2015Publication date: October 12, 2017Applicant: Los Alamos National Security, LLCInventors: Rashi Iyer, Pulak Nath, Jen-Huang Huang
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Publication number: 20170275587Abstract: Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are contacted with a disclosed culture medium under conditions sufficient to support growth, viability, and/or function of the cell types, tissues, and/or organs. The disclosed media can be used in methods of culturing multiple cell types, and in some examples, is used in a platform device including one or more organ devices, for example, by circulating the medium through the one or more organ devices in the platform.Type: ApplicationFiled: September 24, 2015Publication date: September 28, 2017Inventors: Rashi Iyer, Jennifer F. Harris, Jen-Huang Huang, Pulak Nath, Andrzej Przekwas
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Publication number: 20170059555Abstract: Disclosed herein is a platform for holding a biological sample with a movable radiation source that can be used to expose the sample to controlled dosages of radiation in a targeted manner. In some embodiments, the platform includes a support structure and a cartridge for holding a sample. In some embodiments, the support structure includes a support for holding the sample, which may be in a well in the support structure. A radiation source can be adjusted relative to the sample (for example, the distance between the sample and the radiation source is controlled) in order to administer a particular dose of radiation to the sample.Type: ApplicationFiled: August 30, 2016Publication date: March 2, 2017Applicant: Los Alamos National Security, LLCInventors: Rashi Iyer, Piyush Bajaj, Jen-Huang Huang
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Publication number: 20120071430Abstract: Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.Type: ApplicationFiled: November 1, 2011Publication date: March 22, 2012Applicant: Los Alamos National LaboratoryInventors: Rashi Iyer, Kumkum Ganguly, Louis A. Silks
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Patent number: 8071790Abstract: Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.Type: GrantFiled: September 1, 2009Date of Patent: December 6, 2011Assignee: Los Alamos National Security, LLCInventors: Rashi Iyer, Kumkum Ganguly, Louis A. Silks
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Publication number: 20110053890Abstract: Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.Type: ApplicationFiled: September 1, 2009Publication date: March 3, 2011Applicant: Los Alamos National Security, LLC.Inventors: Rashi Iyer, Kumkum Ganguly, Louis A. Silks