Patents by Inventor Rasmus Irming Jolck
Rasmus Irming Jolck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11331396Abstract: Radiation therapy or radiotherapy (RT) is a powerful treatment where precision and accuracy is crucial. Image Guided Radiotherapy (IGRT) facilitates more accurate position verification, correcting for anatomic changes related to internal organ movement. IGRT thereby helps reduce toxicity of radiotherapy and increases relapse-free survival. An inter-correlation point with a fixed position and volume (a marker) can be applied to indicate the point of treatment clearly in both imaging modalities and to localize and track tumors in real time. In this study, we present the development of a marker based on lactose octaacetate:octapropionate 1:1 containing 3 mM PLA-DTPA(Gd), 40% triglyceride, 5% propylene carbonate and 10% XSAIB (sucrose based CT-contrast agent). The injectable marker had high CT contrast (>1000 HU) and displayed clearly visible, stable T1 contrast enhancement (T1˜900 ms) in the rim over at least 3 weeks with clinically observable resolution.Type: GrantFiled: May 24, 2018Date of Patent: May 17, 2022Assignees: TECHNICAL UNIVERSITY OF DENMARK, NANOVI RADIOTHERAPY APSInventors: Thomas Andresen, Rasmus Irming Jølck, Linda Maria Bruun
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Publication number: 20210386669Abstract: The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.Type: ApplicationFiled: June 17, 2021Publication date: December 16, 2021Inventors: Thomas Lars ANDRESEN, Linda Maria BRUUN, Trine Bjørnbo LARSEN, Rasmus Irming JØLCK, Anders Elias HANSEN
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Publication number: 20210275692Abstract: The present disclosure relates to a solution comprising a water insoluble carbohydrate and a fluorescent dye, such as a near infrared (NIR) contrast agent, wherein the solution sets under aqueous conditions, such as in vivo, to form e.g. a gel, a glass, a semi-solid, a solid, a crystal or any mixtures thereof. The disclosure further relates to preparation of such solution and use of such solution for in vivo imaging and/or guidance of surgery or interventional therapeutic procedures.Type: ApplicationFiled: June 19, 2019Publication date: September 9, 2021Inventors: Jonas Rosager HENRIKSEN, Thomas Lars ANDRESEN, Anders Elias HANSEN, Andreas Tue Ingemann JENSEN, Linda Maria BRUUN, Rasmus Irming JØLCK
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Patent number: 11065201Abstract: The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.Type: GrantFiled: November 20, 2015Date of Patent: July 20, 2021Assignee: TECHNICAL UNIVERSITY OF DENMARKInventors: Thomas Lars Andresen, Linda Maria Bruun, Trine Bjørnbo Larsen, Rasmus Irming Jølck, Anders Elias Hansen
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Patent number: 11058780Abstract: The present invention relates to a palpable marker composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 50,000 centipoise (cP) after administration, for use for identifying and/or locating a non palpable tumor. In one embodiment the composition the composition is a liquid before administration into the human or animal body that increases in viscosity by more than 500,000 centipoise (cP) after administration into the human or animal body.Type: GrantFiled: May 19, 2017Date of Patent: July 13, 2021Assignees: TECHNICAL UNIVERSITY OF DENMARK, NANOVI RADIOTHERAPY APSInventors: Thomas Lars Andresen, Rasmus Irming Jølck, Linda Maria Bruun
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Publication number: 20200222560Abstract: Radiation therapy or radiotherapy (RT) is a powerful treatment where precision and accuracy is crucial. Image Guided Radiotherapy (IGRT) facilitates more accurate position verification, correcting for anatomic changes related to internal organ movement. IGRT thereby helps reduce toxicity of radiotherapy and increases relapse-free survival. An inter-correlation point with a fixed position and volume (a marker) can be applied to indicate the point of treatment clearly in both imaging modalities and to localize and track tumors in real time. In this study, we present the development of a marker based on lactose octaacetate:octapropionate 1:1 containing 3 mM PLA-DTPA(Gd), 40% triglyceride, 5% propylene carbonate and 10% XSAIB (sucrose based CT-contrast agent). The injectable marker had high CT contrast (>1000 HU) and displayed clearly visible, stable T1 contrast enhancement (T1˜0.900 ms) in the rim over at least 3 weeks with clinically observable resolution.Type: ApplicationFiled: May 24, 2018Publication date: July 16, 2020Inventors: Thomas Andresen, Rasmus Irming Jølck, Linda Maria Bruun
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Publication number: 20200197541Abstract: The present invention describes an X-ray contrast composition for local administration, wherein the X-ray contrast composition exhibits contrast properties and wherein at least 60% of an administrated amount of said X-ray contrast composition remains more than 24 hours within 10 cm from an injection point when the X-ray contrast composition is administrated to a human or animal body.Type: ApplicationFiled: January 2, 2020Publication date: June 25, 2020Applicants: DANMARKS TEKNISKE UNIVERSITET, NANOVI RADIOTHERAPY APSInventors: Thomas Lars Andresen, Rasmus Irming Jolck, Morten Albrechtsen
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Patent number: 10561746Abstract: The present invention describes an X-ray contrast composition for local administration, wherein the X-ray contrast composition exhibits contrast properties and wherein at least 60% of an administrated amount of said X-ray contrast composition remains more than 24 hours within 10 cm from an injection point when the X-ray contrast composition is administrated to a human or animal body.Type: GrantFiled: May 23, 2014Date of Patent: February 18, 2020Assignees: Danmarks Tekniske Universitet, Nanovi Radiotherapy APSInventors: Thomas Lars Andresen, Rasmus Irming Jolck, Morten Albrechtsen
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Patent number: 10434192Abstract: The present invention relates to novel formulations comprising a plurality of nano-sized solid particles and a gel-forming system, useful, e.g. for imaging of the body of a mammal. Also described are kits comprising such formulations and imaging methods utilizing such formulations or kits.Type: GrantFiled: July 31, 2018Date of Patent: October 8, 2019Assignee: DANMARKS TEKNISKE UNIVERSITETInventors: Rasmus Irming Jølck, Morten Albrechtsen, Lise Nørkjaer Bjerg, Thomas Lars Andresen
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Publication number: 20190275174Abstract: The present invention relates to a palpable marker composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 50,000 centipoise (cP) after administration, for use for identifying and/or locating a non palpable tumor. In one embodiment the composition the composition is a liquid before administration into the human or animal body that increases in viscosity by more than 500,000 centipoise (cP) after administration into the human or animal body.Type: ApplicationFiled: May 19, 2017Publication date: September 12, 2019Applicants: TECHNICAL UNIVERSITY OF DENMARK, NANOVI RADIOTHERAPY APSInventors: Thomas Lars Andresen, Rasmus Irming Jølck, Linda Maria Bruun
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Publication number: 20180339068Abstract: The present invention relates to novel formulations comprising a plurality of nano-sized solid particles and a gel-forming system, useful, e.g. for imaging of the body of a mammal. Also described are kits comprising such formulations and imaging methods utilizing such formulations or kits.Type: ApplicationFiled: July 31, 2018Publication date: November 29, 2018Inventors: Rasmus Irming JØLCK, Morten ALBRECHTSEN, Lise Nørkjaer BJERG, Thomas Lars ANDRESEN
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Publication number: 20180325819Abstract: The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.Type: ApplicationFiled: November 20, 2015Publication date: November 15, 2018Inventors: Thomas Lars ANDRESEN, Linda Maria BRUUN, Trine Bjørnbo LARSEN, Rasmus Irming JØLCK, Anders Elias HANSEN
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Patent number: 10064960Abstract: The present invention relates to novel formulations comprising a plurality of nano-sized solid particles and a gel-forming system, useful, e.g. for imaging of the body of a mammal. Also described are kits comprising such formulations and imaging methods utilizing such formulations or kits.Type: GrantFiled: November 26, 2012Date of Patent: September 4, 2018Assignee: DANMARKS TEKNISKE UNIVERSITETInventors: Rasmus Irming Jolck, Morten Albrechtsen, Lise Norkjaer Bjerg, Thomas Lars Andresen
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Publication number: 20160089454Abstract: The present invention describes an X-ray contrast composition for local administration, wherein the X-ray contrast composition exhibits contrast properties and wherein at least 60% of an administrated amount of said X-ray contrast composition remains more than 24 hours within 10 cm from an injection point when the X-ray contrast composition is administrated to a human or animal body.Type: ApplicationFiled: May 23, 2014Publication date: March 31, 2016Applicants: DANMARKS TEKNISKE UNIVERSITET, NANOVI RADIOTHERAPY APSInventors: Thomas Lars Andresen, Rasmus Irming Jolck, Morten Albrechtsen
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Patent number: 9161993Abstract: The present application discloses a nanoparticle comprising compounds of the formula A-B-C(-D), wherein A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; B designates a cleavable linker; C designates an anionic moiety having a net charge of at least ?2 at pH 6.0; and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue; and wherein the average net charge of the compounds is at least ?1 at pH 6.0. The application also discloses the individual compounds of the formula A-B-C(-D) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal.Type: GrantFiled: May 16, 2012Date of Patent: October 20, 2015Assignee: Danmarks Tekniske UniversitetInventors: Rasmus Irming Jølck, Jonas Rosager Henriksen, Torben Gjetting, Thomas Lars Andresen
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Publication number: 20140343413Abstract: The present invention relates to novel formulations comprising a plurality of nano-sized solid particles and a gel-forming system, useful, e.g. for imaging of the body of a mammal. Also described are kits comprising such formulations and imaging methods utilizing such formulations or kits.Type: ApplicationFiled: November 26, 2012Publication date: November 20, 2014Inventors: Rasmus Irming Jølck, Morten Albrechtsen, Lise Norkjaer Bjerg, Thomas Lars Andresen
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Publication number: 20140328897Abstract: The present application discloses a nanoparticle comprising compounds of the formula A-B-C(-D), wherein A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; B designates a cleavable linker; C designates an anionic moiety having a net charge of at least ?2 at pH 6.0; and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue; and wherein the average net charge of the compounds is at least ?1 at pH 6.0. The application also discloses the individual compounds of the formula A-B-C(-D) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal.Type: ApplicationFiled: May 16, 2012Publication date: November 6, 2014Applicant: DANMARKS TEKNISKE UNIVERSITETInventors: Rasmus Irming Jølck, Jonas Rosager Henriksen, Torben Gjetting, Thomas Lars Andresen