Patents by Inventor Raul Cuero RENGIFO

Raul Cuero RENGIFO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240102036
    Abstract: Described herein are biological devices and methods for using the same to produce a polyactive carbohydrate. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a chitin synthase, a chitosanase, 5 and a chitin deacetylase, and, optionally, lipase, regulatory sequence CHR1, transglycosylase, dehydrogenase, and/or (1?3), (1?4)-?-glucan synthase. Methods for using the polyactive carbohydrate are also provided herein including, but not limited to, increasing plant hormone production and improving the appearance and root strength of plants and production of polyurethane biofoams.
    Type: Application
    Filed: October 6, 2020
    Publication date: March 28, 2024
    Inventor: Raul CUERO RENGIFO
  • Publication number: 20230340497
    Abstract: Described herein are anti-microbial and UV-protective biological devices and extracts produced therefrom. The biological devices include microbial cells transformed with a DNA construct containing genes for producing proteins such as, for example, zinc-related protein/oxidase, silicatein, silaffin, and alcohol dehydrogenase. In some instances, the biological devices also include a gene for lipase. Methods for producing and using the devices are also described herein. Finally, compositions and methods for using the devices and extracts to kill microbial species or prevent microbial growth and to reduce or prevent UV-induced damage or exposure to materials, items, plants, and human and animal subjects are described herein. Also disclosed are biological devices producing polyactive carbohydrates and carbo sugars, as well as compositions and articles incorporating both extracts from these devices and the anti-microbial and UV-protective extracts.
    Type: Application
    Filed: May 15, 2023
    Publication date: October 26, 2023
    Inventors: Raul CUERO RENGIFO, Juliana LONDONO MURILLO
  • Patent number: 11781157
    Abstract: Described herein are biological devices and methods for using the same to produce oxidized zinc. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a zinc-related protein, an alkaline phosphatase, and an alcohol dehydrogenase. In some instances, the biological devices also include a gene for lipase. The oxidized zinc compositions produced herein have numerous applications.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: October 10, 2023
    Assignee: BIOCAPITAL HOLDINGS, LLC
    Inventors: Raul Cuero Rengifo, Juliana Londono Murillo
  • Publication number: 20230212588
    Abstract: Described herein are devices and methods for increasing the production of steviol glycosides, which have industrial and economic value. The steviol glycosides produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods and do not have a bitter aftertaste, making them better suited as flavor-enhancing additives to food, pharmaceutical, and nutritional supplement products.
    Type: Application
    Filed: June 9, 2022
    Publication date: July 6, 2023
    Applicant: Bio Capital Holdings, LLC
    Inventor: Raul CUERO RENGIFO
  • Patent number: 11692192
    Abstract: Described herein are anti-microbial and UV-protective biological devices and extracts produced therefrom. The biological devices include microbial cells transformed with a DNA construct containing genes for producing proteins such as, for example, zinc-related protein/oxidase, silicatein, silaffin, and alcohol dehydrogenase. In some instances, the biological devices also include a gene for lipase. Methods for producing and using the devices are also described herein. Finally, compositions and methods for using the devices and extracts to kill microbial species or prevent microbial growth and to reduce or prevent UV-induced damage or exposure to materials, items, plants, and human and animal subjects are described herein. Also disclosed are biological devices producing polyactive carbohydrates and carbo sugars, as well as compositions and articles incorporating both extracts from these devices and the anti-microbial and UV-protective extracts.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 4, 2023
    Assignee: BIOCAPITAL HOLDINGS, LLC
    Inventors: Raul Cuero Rengifo, Juliana Londoño Murillo
  • Patent number: 11639505
    Abstract: Described herein are UV-resistant or UV-protective biological devices and extracts produced therefrom. The biological devices include microbial cells transformed with a DNA construct containing genes for producing UV-resistant proteins such as, for example, hexokinase, heat shock proteins, alcohol dehydrogenase, transferrin, flavonol synthase, zinc oxidase, and iron oxidase. Methods for producing and using the devices are also described herein. Finally, compositions and methods for using the devices and extracts to reduce or prevent UV-induced damage or exposure to materials, items, plants, and human and animal subjects are described herein.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: May 2, 2023
    Assignee: Bio Capital Holdings, LLC
    Inventor: Raul Cuero Rengifo
  • Patent number: 11635439
    Abstract: Described herein are devices and methods for simultaneously expressing amyloid precursor protein and TonB protein. These devices and methods increase the production of these two proteins while also minimizing costs, making the proteins more widely accessible for medical research purposes, including the development of diagnostic tests for numerous diseases associated with elevated production of amyloid proteins. The amyloid precursor protein and TonB produced by the devices and methods described herein, as well as the devices themselves, can be used in experiments designed to model the interactions between metals and amyloids such as ?-amyloid that are characteristic of numerous diseases such as Alzheimer's. Finally, provided herein are diagnostic tests that can detect Alzheimer's disease in samples from patients; the tests are sensitive enough to identify diseases such as Alzheimer's even at pre-clinical stages, before the appearance of symptoms.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: April 25, 2023
    Assignee: Bio Capital Holdings, LLC
    Inventors: Raul Cuero Rengifo, Diana Vasquez Forero, Juliana Londoño Murillo
  • Patent number: 11603549
    Abstract: Described herein are devices and methods for using the same to produce carotenoids. The carotenoids produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods. The devices and methods disclosed herein also enhance one or more physical properties of plants treated with the devices described herein.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: March 14, 2023
    Assignee: Bio Capital Holdings, LLC
    Inventor: Raul Cuero Rengifo
  • Patent number: 11365417
    Abstract: Described herein are devices and methods for increasing the production of steviol glycosides, which have industrial and economic value. The steviol glycosides produced by the devices and methods disclosed herein do not require the ultra purification that is common in conventional or commercial methods and do not have a bitter aftertaste, making them better suited as flavor-enhancing additives to food, pharmaceutical, and nutritional supplement products.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: June 21, 2022
    Assignee: Bio Capital Holdings, LLC
    Inventor: Raul Cuero Rengifo
  • Publication number: 20220183301
    Abstract: Described herein are genelight cultures and extracts and methods of making and using thereof. In one aspect, the method of making a genelight culture or extract includes the steps of (a) making a DNA construct containing genes for producing a heat shock protein, RuBisCO large subunit 1, tonB, hydrogenase, and a P-type ATPase, (b) introducing the DNA construct into host microbial cells via transformation or transfection, and (c) culturing the microbial cells to produce the genelight cultures and extracts. The compositions of these cultures and extracts can be tailored to have specific properties such as the ability to provide power to a light emitting diode. The cultures and extracts have further uses including enhancing the growth of plants and as supplemental nutrients of cultures of industrially important microorganisms. The cultures and extracts further have UV-protective properties. Also described herein are microbial electric circuits containing the cultures and extracts described herein.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Inventors: Raul CUERO RENGIFO, Tatiana VARELA TORO, Isabella GIRALDO BADILLO, María DÍAZ SÁNCHEZ, Johny Mateo SANCHEZ GIRALDO, Juliana LONDOÑO MURILLO
  • Publication number: 20220145240
    Abstract: Described herein are carbo-ionic cultures and extracts and applications thereof. The carbo-ionic cultures are grown in media containing an organic component and an inorganic component and the proportions and compositions of these components can be tailored to produce carbo-ionic extracts with specific properties such as, for example, the ability to provide power to a light emitting diode (LED) with a specific voltage. The carbo-ionic cultures and extracts have further uses including enhancing the growth of plants, including plants grown from tissue culture, and as supplemental nutrients for cultures of industrially, commercially, and/or scientifically-important microorganisms. Also described herein are microbial electric circuits comprising the carbo-ionic cultures and extracts described herein as well as applications of those circuits.
    Type: Application
    Filed: March 10, 2020
    Publication date: May 12, 2022
    Inventors: Raul CUERO RENGIFO, Juliana LONDOÑO MURILLO, Isabela GIRALDO BADILLO, Tatiana VARELA TORO, Johny Mateo SANCHEZ GIRALDO, María DÍAZ SÁNCHEZ
  • Publication number: 20210382063
    Abstract: Described herein are glucose sensors. The sensors are composed of host cells incorporating DNA devices specifically designed to produce fluorescence when the cells come into contact with glucose from a patient sample. Once the fluorescence has been quantified, it can be correlated with the amount of glucose present in the sample. Also described herein are extracts from the host cells that can sense and measure glucose levels in a patient. The devices and extracts disclosed herein are inexpensive but sensitive and accurate enough for use in both home and clinical testing situations. The devices and extracts disclosed herein are also useful for diagnosis of diabetes, pre-diabetes, or other diseases associated with elevated glucose levels.
    Type: Application
    Filed: December 4, 2019
    Publication date: December 9, 2021
    Inventors: Raul CUERO RENGIFO, Laura Sanchez LONDONO
  • Publication number: 20210332370
    Abstract: Described herein are biological devices and methods for using the same to produce carbo sugars. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a cellulose synthase and galactomannan galactosyltransferase. In some instances, the biological devices also include a gene for lipase. Methods for altering the viscosity of petroleum oil using the carbo sugars are also described herein. Finally, methods for degreasing or decontaminating water mixed with petroleum oil or other fatty substances or a surface coated with petroleum oil or other fatty substances using the carbo sugars are described herein.
    Type: Application
    Filed: May 10, 2021
    Publication date: October 28, 2021
    Inventors: Raul CUERO RENGIFO, Juliana LONDOÑO MURILLO, Mariana SANCHEZ LONDOÑO, Daniel AGUDELO VALENCIA, Juan Miguel SANCHEZ BUSTAMANTE, Mario Antonio FRANCO JIMENEZ, Lina Clemencia SANCHEZ BUSTAMANTE
  • Patent number: 11149294
    Abstract: Described herein are biological devices and methods for using the same to produce carbo sugars. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a cellulose synthase and galactomannan galactosyltransferase. In some instances, the biological devices also include a gene for lipase. Methods for altering the viscosity of petroleum oil using the carbo sugars are also described herein. Finally, methods for degreasing or decontaminating water mixed with petroleum oil or other fatty substances or a surface coated with petroleum oil or other fatty substances using the carbo sugars are described herein.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: October 19, 2021
    Assignee: BIOCAPITAL HOLDINGS, LLC
    Inventors: Raul Cuero Rengifo, Juliana Londoño Murillo, Mariana Sanchez Londoño, Daniel Agudelo Valencia, Juan Miguel Sanchez Bustamante, Mario Antonio Franco Jimenez, Lina Clemencia Sanchez Bustamante
  • Publication number: 20210261997
    Abstract: Described herein are biological devices and methods for using the same to produce a polyactive carbohydrate. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a chitin synthase, a chitosanase, and a chitin deacetylase. In some instances, the biological devices also include a gene for lipase. Methods for using the polyactive carbohydrate are also provided herein, including, but not limited to, enhancing the physiological properties of plants; medical applications; applications in the construction, materials science, and home goods industries; personal care, grooming, cosmetics, and oral care compositions containing the polyactive carbohydrate; methods for water decontamination; and the production of polyurethane s.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 26, 2021
    Inventors: Raul CUERO RENGIFO, Juliana LONDONO MURILLO
  • Publication number: 20210261986
    Abstract: Described herein are biological devices and methods for using the same to produce oxidized zinc. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a zinc-related protein, an alkaline phosphatase, and an alcohol dehydrogenase. In some instances, the biological devices also include a gene for lipase. The oxidized zinc compositions produced herein have numerous applications.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 26, 2021
    Inventors: Raul CUERO RENGIFO, Juliana LONDONO MURILLO
  • Patent number: 11001848
    Abstract: Described herein are biological devices and methods for using the same to produce carbo sugars. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a cellulose synthase and galactomannan galactosyltransferase. In some instances, the biological devices also include a gene for lipase. Methods for altering the viscosity of petroleum oil using the carbo sugars are also described herein. Finally, methods for degreasing or decontaminating water mixed with petroleum oil or other fatty substances or a surface coated with petroleum oil or other fatty substances using the carbo sugars are described herein.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: May 11, 2021
    Assignee: BIOCAPITAL HOLDINGS, LLC
    Inventors: Raul Cuero Rengifo, Juliana Londoño Murillo, Mariana Sanchez Londoño, Daniel Agudelo Valencia, Juan Miguel Sanchez Bustamante, Mario Antonio Franco Jimenez, Lina Clemencia Sanchez Bustamante
  • Patent number: 10995345
    Abstract: Described herein are biological devices and methods for using the same to produce oxidized zinc. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a zinc-related protein, an alkaline phosphatase, and an alcohol dehydrogenase. In some instances, the biological devices also include a gene for lipase. The oxidized zinc compositions produced herein have numerous applications.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: May 4, 2021
    Assignee: BIOCAPITAL HOLDINGS, LLC
    Inventors: Raul Cuero Rengifo, Juliana Londono Murillo
  • Patent number: 10995353
    Abstract: Described herein are biological devices and methods for using the same to produce a polyactive carbohydrate. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a chitin synthase, a chitosanase, and a chitin deacetylase. In some instances, the biological devices also include a gene for lipase. Methods for using the polyactive carbohydrate are also provided herein, including, but not limited to, enhancing the physiological properties of plants; medical applications; applications in the construction, materials science, and home goods industries; personal care, grooming, cosmetics, and oral care compositions containing the polyactive carbohydrate; methods for water decontamination; and the production of polyurethanes.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: May 4, 2021
    Assignee: BIOCAPITAL HOLDINGS, LLC
    Inventors: Raul Cuero Rengifo, Juliana Londono Murillo
  • Publication number: 20210017525
    Abstract: Described herein are anti-microbial and UV-protective biological devices and extracts produced therefrom. The biological devices include microbial cells transformed with a DNA construct containing genes for producing proteins such as, for example, zinc-related protein/oxidase, silicatein, silaffin, and alcohol dehydrogenase. In some instances, the biological devices also include a gene for lipase. Methods for producing and using the devices are also described herein. Finally, compositions and methods for using the devices and extracts to kill microbial species or prevent microbial growth and to reduce or prevent UV-induced damage or exposure to materials, items, plants, and human and animal subjects are described herein. Also disclosed are biological devices producing polyactive carbohydrates and carbo sugars, as well as compositions and articles incorporating both extracts from these devices and the anti-microbial and UV-protective extracts.
    Type: Application
    Filed: February 22, 2019
    Publication date: January 21, 2021
    Inventors: Raul CUERO RENGIFO, Juliana LONDOÑO MURILLO