Patents by Inventor Raul G. Barletta

Raul G. Barletta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identification of virulence determinants
    Patent number: 7740867
    Abstract: Disclosed are methods for the determination of virulence determinants in bacteria and in particular bacteria of the genus Mycobacterium. Also disclosed are compositions and methods for stimulating an immune response in an animal using bacteria and virulence determinants identified by the methods of the present invention.
    Type: Grant
    Filed: November 27, 2007
    Date of Patent: June 22, 2010
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Raul G. Barletta, N. Beth Harris
  • Method for Identification of Virulence Determinants
    Publication number: 20080166321
    Abstract: Disclosed are methods for the determination of virulence determinants in bacteria and in particular bacteria of the genus Mycobacterium. Also disclosed are compositions and methods for stimulating an immune response in an animal using bacteria and virulence determinants identified by the methods of the present invention.
    Type: Application
    Filed: November 27, 2007
    Publication date: July 10, 2008
    Applicant: Board of Regents of the University of Nebraska,The
    Inventors: Raul G. Barletta, N. Beth Harris
  • Recombinant mycobacteria overexpressing D-alanine ligase gene and uses therefore
    Patent number: 7371571
    Abstract: Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of D-alanine into mycobacterial peptidoglycan, the backbone of the mycobacterial cell wall. These overproducing strains may be used as reference strains in in vitro screening methods to identify antimycobacterial agents.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: May 13, 2008
    Assignee: Board of Regents University of Nebraska - Lincoln
    Inventors: Raul G. Barletta, Zhengyu Feng
  • D-alanine racemase mutants of mycobacteria and uses therefore
    Patent number: 6929799
    Abstract: The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of peptidoglycan that forms the backbone of the bacterial cell wall. The present invention is also directed to methods of making live-attenuated vaccines against pathogenic mycobacteria using such alrA mutants and to the vaccines made according to such methods. The present invention is further directed to use of alrA mutants in methods for screening antimycobacterial agents that are synergistic with peptidoglycan inhibitors. Finally, the present invention is directed to methods to identify new pathways of D-alanine biosynthesis for use in developing new drugs targeting peptidoglycan biosynthesis in mycobacteria and to identify vaccines useful against pathogenic mycobacteria.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: August 16, 2005
    Assignee: Board of Regents University of Nebraska-Lincoln
    Inventors: Raul G. Barletta, Ofelia Barletta-Chacon
  • Recombinant mycobacteria overexpressing D-alanine ligase gene and uses therefore
    Publication number: 20040241830
    Abstract: Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of D-alanine into mycobacterial peptidoglycan, the backbone of the mycobacterial cell wall. These overproducing strains may be used as reference strains in in vitro screening methods to identify antimycobacterial agents.
    Type: Application
    Filed: December 17, 2003
    Publication date: December 2, 2004
    Applicant: The Board of Regents, University of Nebraska-Lincoln
    Inventors: Raul G. Barletta, Zhengyu Feng
  • D-alanine racemase mutants of mycobacteria and uses therefore
    Publication number: 20030133952
    Abstract: The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of peptidoglycan that forms the backbone of the bacterial cell wall. The present invention is also directed to methods of making live-attenuated vaccines against pathogenic mycobacteria using such alrA mutants and to the vaccines made according to such methods. The present invention is further directed to use of alrA mutants in methods for screening antimycobacterial agents that are synergistic with peptidoglycan inhibitors. Finally, the present invention is directed to methods to identify new pathways of D-alanine biosynthesis for use in developing new drugs targeting peptidoglycan biosynthesis in mycobacteria and to identify vaccines useful against pathogenic mycobacteria.
    Type: Application
    Filed: December 18, 2002
    Publication date: July 17, 2003
    Inventors: Raul G. Barletta, Ofelia Barletta-Chacon
  • Identification of virulence determinants
    Publication number: 20020064861
    Abstract: Disclosed are methods for the determination of virulence determinants in bacteria and in particular bacteria of the genus Mycobacterium. Also disclosed are compositions and methods for stimulating an immune response in an animal using bacteria and virulence determinants identified by the methods of the present invention.
    Type: Application
    Filed: January 11, 2001
    Publication date: May 30, 2002
    Inventors: Raul G. Barletta, N. Beth Harris