Patents by Inventor Ravi I. Thadhani

Ravi I. Thadhani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis, prognosis, and treatment of kidney disease
    Patent number: 9549964
    Abstract: The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: January 24, 2017
    Assignees: Beth Israel Deaconess Medical Center, Inc., The General Hospital Corporation
    Inventors: Anders H. Berg, S. Ananth Karumanchi, Ravi I. Thadhani
  • Vitamin D receptor agonists and uses thereof
    Patent number: 9499488
    Abstract: This invention features vitamin D receptor agonists, and their use in treating bone disorders, cardiovascular disease, hyperparathyroidism, immune disorders, proliferative disease, renal disease, and thrombosis.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: November 22, 2016
    Assignees: Beth Israel Deaconess Medical Center, Inc., The General Hospital Corporation
    Inventors: Peter M. Kang, S. Ananth Karumanchi, Santosh Khedkar, Alan Rigby, Ravi I. Thadhani
  • VITAMIN D RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20140378507
    Abstract: This invention features vitamin D receptor agonists, and their use in treating bone disorders, cardiovascular disease, hyperparathyroidism, immune disorders, proliferative disease, renal disease, and thrombosis.
    Type: Application
    Filed: July 11, 2012
    Publication date: December 25, 2014
    Applicant: Beth Israel Deaconess Medical Center, In.
    Inventors: Peter Kang, Ananth Karumanchi, Santosh Khedkar, Alan Rigby, Ravi I. Thadhani
  • DIAGNOSIS, PROGNOSIS, AND TREATMENT OF KIDNEY DISEASE
    Publication number: 20140228296
    Abstract: The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.
    Type: Application
    Filed: July 13, 2012
    Publication date: August 14, 2014
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Anders H. Berg, S. Ananth Karumanchi, Ravi I. Thadhani
  • SCREENING FOR GESTATIONAL DISORDERS
    Publication number: 20080213794
    Abstract: The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy.
    Type: Application
    Filed: January 9, 2008
    Publication date: September 4, 2008
    Applicants: THE GENERAL HOSPITAL CORPORATION, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Ravi I. Thadhani, S. Ananth Karumanchi
  • Screening for gestational disorders
    Patent number: 7344892
    Abstract: The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: March 18, 2008
    Assignees: Beth Israel Deaconess Medical Center, Inc., The General Hospital Corporation
    Inventors: Ravi I. Thadhani, S. Ananth Karumanchi
  • Screening for gestational disorders
    Patent number: 7323346
    Abstract: The invention relates to methods and compositions for identifying pregnant subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy, and as early as the first trimester.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: January 29, 2008
    Assignees: The General Hospital Corporation, Harvard University
    Inventors: Ravi I. Thadhani, Myles S. Wolf, Tanya Lynn Knickerbocker, Gavin MacBeath