Abstract: A source device includes various sensors, such as a GPS receiver. The source device provides operation context data to a server that indicates movement of the source device. The source device may also provide a movement context. The server also evaluates usage of data from the device by other applications or devices to determine a usage context. Based on the movement, operation, and usage contexts, the server selects a frequency at which data is collected for a sensor and a frequency at which the data is transmitted to the server. For example, where the device is not moving or is indoors, less location data is collected. Where no user is tracking the device, location data may be transmitted less frequently and may also be collected less frequently.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Various methods, systems, and computer program products are disclosed for communicating location-based digital components to a mobile and other devices. A natural language processor component can parse an input audio signal to identify a request and a keyword. A content selector can select digital components based on keyword and request. An audio signal generator component can generate an output signal that includes a selected digital components. An interface can transmit the output signal to cause a client computing device to drive a speaker to generate an acoustic wave corresponding to the output signal prior to occurrence of at least one of the first action and the second action.

Abstract: Systems and methods for pre-loading and displaying intervening content, such as advertisements, on a mobile device during latency periods, such as when an advertiser landing page is requested by that device, are provided herein. Intervening content may be pre-loaded on to the device and associated with one or more particular advertisements such that selecting/interacting with the associated advertisement triggers intervening content display during known or detected periods of latency. In some cases, a latency threshold or thresholds may determine one or more types of content to present, and/or a content presentation sequence.

Abstract: Systems and methods for pre-loading and displaying intervening content, such as advertisements, on a mobile device during latency periods, such as when an advertiser landing page is requested by that device, are provided herein. Intervening content may be pre-loaded on to the device and associated with one or more particular advertisements such that selecting/interacting with the associated advertisement triggers intervening content display during known or detected periods of latency. In some cases, a latency threshold or thresholds may determine one or more types of content to present, and/or a content presentation sequence.

Abstract: Systems and methods for identifying device location are provided. The method can include providing, by a mobile computing device, at least a first ultrasonic signal to a first and a second self-organizing beacon device. The method can include receiving, by the mobile computing device, a first radio frequency signal including the location of the first beacon device and a second radio frequency signal including the location of the second beacon device. The method can further include determining a first time-of-flight associated with the first beacon device and a second time-of-flight associated with the second beacon device. The method can include determining a location of the mobile computing device based at least in part on the first time-of-flight, the second time-of-flight, the location of the first beacon device, and the location of the second beacon device.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

Abstract: Systems and methods for pre-loading and displaying intervening content, such as advertisements, on a mobile device during latency periods, such as when an advertiser landing page is requested by that device, are provided herein. Intervening content may be pre-loaded on to the device and associated with one or more particular advertisements such that selecting/interacting with the associated advertisement triggers intervening content display during known or detected periods of latency. In some cases, a latency threshold or thresholds may determine one or more types of content to present, and/or a content presentation sequence.

Abstract: Systems and methods for identifying device location are provided. The method can include providing, by a mobile computing device, at least a first ultrasonic signal to a first and a second self-organizing beacon device. The method can include receiving, by the mobile computing device, a first radio frequency signal including the location of the first beacon device and a second radio frequency signal including the location of the second beacon device. The method can further include determining a first time-of-flight associated with the first beacon device and a second time-of-flight associated with the second beacon device. The method can include determining a location of the mobile computing device based at least in part on the first time-of-flight, the second time-of-flight, the location of the first beacon device, and the location of the second beacon device.

Abstract: Systems and methods for identifying device location are provided. The method can include providing, by a mobile computing device, at least a first ultrasonic signal to a first and a second self-organizing beacon device. The method can include receiving, by the mobile computing device, a first radio frequency signal including the location of the first beacon device and a second radio frequency signal including the location of the second beacon device. The method can further include determining a first time-of-flight associated with the first beacon device and a second time-of-flight associated with the second beacon device. The method can include determining a location of the mobile computing device based at least in part on the first time-of-flight, the second time-of-flight, the location of the first beacon device, and the location of the second beacon device.

Abstract: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.