Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Abstract: Example implementations relate to the processing of refresh token requests at an API gateway. The API gateway determines a first time associated with receipt of the refresh token request and a second time associated with the generation of a current access token. The current access token and a refresh token in the refresh token request are provided by the API gateway to the client device for accessing a backend service. The API gateway determines whether a difference between the first time and the second time is within a pre-defined threshold duration. When the difference between the first time and the second time is within the pre-defined threshold, the API gateway denies the refresh token request for generating the new access token and transmits the current access token back to the client device.

Abstract: A magnetic resonance pulse sequence technique may acquire a water reference spectrum and two water suppressed metabolite spectra and with frequency selective inversion pulse centered at either single frequency, at multiple frequencies, or in a single acquisition. Subtraction of the inverted from non-inverted water suppressed metabolite spectrum results in single or a combination of specific metabolite peak/peaks alone with a flat baseline for easier quantification.

Abstract: An information management system implements a media agent that communicates with a network area storage (NAS) device to receive secondary copy data that has been backed-up by the NAS. The secondary copy data may include primary data managed or maintained by the NAS. The secondary copy data may be in a proprietary format or other data format specific to the NAS. The NAS may prepare metadata or other information about the secondary copy data that informs the media agent as to the contents of the secondary copy data. The media agent may segment the secondary copy data into one or more backup chunks for storing in a secondary storage device. In addition, each of the backup chunks may be associated with backup chunk metadata, where the backup chunk metadata includes information that describes certain information stored by a corresponding backup chunk.

Abstract: A multiply-accumulate computation is performed using digital logic circuits. To perform the computation, a plurality of target signals are received at a respective plurality of ripple counters. The counter outputs of the respective ripple counters are scaled by setting stop count values. Counter outputs of the respective ripple counters are adjusted with respective constant values by setting counter reset values at the respective ripple counters. Each count pulses of the target signals for an adjusted period. The count values of the ripple counters are summed. The results may be used to calculate an average value for an adaptive voltage and frequency scaling process.

Abstract: A system and method for measuring power supply variations are described. A functional unit includes one or more power supply monitors capable of measuring power supply variations. The power supply monitors forego use of a clock signal from clock generating circuitry and forego use of a reference voltage from a reference power supply. The power supply monitors use an output of a source ring oscillator as a clock signal for the sequential elements of a counter. The counter measures a number of revolutions of a measuring ring oscillator within a period of the output of the source oscillator. The revolutions of the measuring ring oscillator are associated with a number of rising edges and falling edges of the output signal of the measuring ring oscillator. An encoder converts the output of the sequential elements to a binary value, and sends the binary value to an external age tracking unit.

Abstract: A system and method for measuring power supply variations are described. A functional unit includes one or more power supply monitors capable of measuring power supply variations. The power supply monitors forego use of a clock signal from clock generating circuitry and forego use of a reference voltage from a reference power supply. The power supply monitors use an output of a source ring oscillator as a clock signal for the sequential elements of a counter. The counter measures a number of revolutions of a measuring ring oscillator within a period of the output of the source oscillator. The revolutions of the measuring ring oscillator are associated with a number of rising edges and falling edges of the output signal of the measuring ring oscillator. An encoder converts the output of the sequential elements to a binary value, and sends the binary value to an external age tracking unit.

Abstract: In one form, a power supply monitor including a current controlled oscillator circuit, a time-to-digital converter, and an output divider. The current controlled oscillator circuit has an input for receiving a power supply voltage to be measured, and an output for providing a frequency signal having a frequency linearly proportional to the power supply voltage. The time-to-digital converter has an input coupled to the output of the current controlled oscillator circuit, and an output for providing a count signal representative of a number of cycles of a reference clock signal per cycle of the frequency signal. The output divider has an input coupled to the output of the time-to-digital converter, and an output for providing a divided count signal representative of a value of the power supply voltage, and provides the divided count signal by dividing a fixed number by the count signal.

Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Abstract: A compound of Formula (1) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: wherein R1, R2, R3, R4, R5 and R6 are as defined herein.

Abstract: The present invention provides processes for the preparation of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3,5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Abstract: CEST imaging technique and MR scanning are used as an MRI method for detecting levels of lactate in vivo by exploiting the exchange of —OH protons on lactate with bulk water. In accordance with this method, one first obtains a lactate CEST MRI map of a slice of the body of a patient. A contrast agent such as pyruvate, glucose or glutamine is administered and a post-administration CEST MRI map is obtained. The difference in the spatial maps indicates the level of expression of lactate in the tissue of interest.

Abstract: A non-invasive imaging approach using CEST and MRS may be used to monitor the cleavage of the poly-L-glutamate (PLG) backbone. The cleavage of PLG by cathespsin B can expose exchangeable —NH2 protons in the PLG that are then monitored non-invasively through CEST. The technique can provide direct information on malignant tissue and tumor aggressiveness, and can also be used to monitor treatment.

Abstract: The present invention related to stable N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl) -1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl) octanamide (2R,3R)-2,3-dihydroxysuccinate premix of formula (Ia) and its process for preparation thereof.

Abstract: Systems and methods for constructing extensible event log with JavaScript Object Notation (JSON) encoded payload data. The system includes a computing device. The computing device may be connected to a device, where an event has occurred. The device may send a message to the management software of the computing device based on the event, where the message includes information corresponding to an event occurred at the device and payload data of the event. When the management software receives the message, the management software may determine an event type of the event based on the information, and then convert the payload data of the event to encoded payload data in an extensible format, such as the JSON format. Thus, the management software may generate and store an event log comprising the event type and the encoded payload data.

Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Abstract: A new ecosystem monitoring solution provides novel features including a dashboard service, a dashboard notifier, a near real time query processor. The dashboard service can continuously aggregate, through the dashboard notifier and optionally dashboard agents, metadata from disparate ecosystem components of a complex computing platform or ecosystem. The metadata include metrics of crawling, data ingestion, and content enrichment activities and health information of the disparate ecosystem components. The metrics are processed with respect to a time window utilizing an expression tree dynamically constructed by the query processor. The query processor can navigate the expression tree to form collection models. Each collection has aggregation functions for aggregating a set of metrics specified in a view model.

Abstract: In one form, a power supply monitor including a current controlled oscillator circuit, a time-to-digital converter, and an output divider. The current controlled oscillator circuit has an input for receiving a power supply voltage to be measured, and an output for providing a frequency signal having a frequency linearly proportional to the power supply voltage. The time-to-digital converter has an input coupled to the output of the current controlled oscillator circuit, and an output for providing a count signal representative of a number of cycles of a reference clock signal per cycle of the frequency signal. The output divider has an input coupled to the output of the time-to-digital converter, and an output for providing a divided count signal representative of a value of the power supply voltage, and provides the divided count signal by dividing a fixed number by the count signal.

Abstract: A temperature sensor has a first transistor with a gate voltage tied to maintain the first transistor in an off state with leakage current flowing through the transistor, the leakage current varying with temperature. A second transistor is coupled to the first transistor and receives a gate voltage to keep the second transistor in an on state. A current mirror mirrors the leakage current and supplies a mirrored current used to control a frequency of an oscillator signal varies with the mirrored current. The temperature of the first transistor is determined based the frequency of the oscillator signal.