Abstract: In accordance with aspects of the inventive concepts, provided is a marker device, comprising: an elongate element; a needle disposed at a distal end of the elongate element; and at least one radiopaque marker element coupled to or disposed on at least a portion of an outer surface of the elongate element. The at least one marker can include radiopaque portions. The at least one radiopaque marker element can be or include a helical coil wrapped around a suture element. Also provided is a method of marking a surgical site comprising suturing a marker device into the surgical site. The method can include sewing or otherwise attaching the marker device to the soft tissue at boundaries of an excision site. Also provided is a method of making a marker device.

Abstract: The invention relates to a method for production of a radio-isotope (4) from a target (3), containing a precursor (1) of said radio-isotope (4), using a beam of accelerated particles, comprising the following method steps: preparation of a target (3), containing the precursor (1) of the radioisotope (4), irradiation of said target (3) within an irradiation chamber (10) with a beam of accelerated particles in order to induce the transmutation of the precursor (1) into the radio-isotope (4), heating said target (3) in order to bring about the efflux of the radio-isotope (4) from the target (3), collection of said radio-isotope (4), extracted as a gas and condensation of said radio-isotope (4) into a solid or liquid. The invention further relates to a device for carrying out the above method and use of the device and method for the production of palladium 103 from rhodium 103.