Abstract: The present invention provides apelin receptor (APLNR) modulators that bind to APLNR and methods of using the same. The invention includes APLNR modulators such as antibodies, or antigen-binding fragments thereof, which inhibit or attenuate APLNR-mediated signaling. The invention includes APLNR modulators such as antibodies, or antibody fusion proteins thereof, that activate APLNR-mediated signaling. According to certain embodiments of the invention, the antibodies or antigen-binding fragments or antibody fusion proteins are fully human antibodies that bind to human APLNR with high affinity. The APLNR modulators of the invention are useful for the treatment of diseases and disorders associated with APLNR signaling and/or APLNR cellular expression, such as cardiovascular diseases, angiogenesis diseases, metabolic diseases and fibrotic diseases.

Abstract: Sanitizing cleaning/rinse aid compositions for various applications including institutional machine warewash sanitizing are disclosed. In particular, concentrated and use compositions, such as concentrated liquid rinse aid compositions or ware wash detergents, employing an amine-based surfactant and a defoaming agent are disclosed. In particular, the present disclosure provides compositions and methods for providing a sanitizing rinse with desired antimicrobial efficacy against a broad spectrum of gram-negative microbes, suitable foaming profiles, and beneficial applications of use of the same.

Abstract: The disclosure is directed to cleaning compositions, methods of making the cleaning compositions, and methods of using the cleaning compositions. The cleaning compositions comprise an enzyme composition and a nonionic surfactant having an HLB between 10 and 22. Preferably, the enzyme compositions included in the cleaning compositions comprise a cellulase, an AA9 polypeptide having cellulolytic enhancing activity, a hemicellulase, an esterase, an expansin, a laccase, a ligninolytic enzyme, a pectinase, a peroxidase, a protease, a swollenin, or a combination or mixture thereof. The compositions are useful for degradation of bacterial cellulose.

Abstract: Warewash detergent compositions with reducing agents to overcome corrosion challenges in stainless steel dish machines subject to conditions from chlorine sanitizing rinse steps (or other oxidizing chlorine containing compositions) are provided. Detergent compositions or booster compositions used in combination with detergents beneficially containing a reducing agent that reacts with chlorine introduced in sanitizing rinse steps that follow detergent cleaning steps are provided. Methods for ware washing using the detergent compositions with reducing agents and methods for reducing residual chlorine in a ware washing cycle are also provided.

Abstract: Sanitizing cleaning/rinse aid compositions for various applications including institutional machine warewash sanitizing are disclosed. In particular, concentrated and use compositions, such as concentrated liquid rinse aid compositions or ware wash detergents, employing an amine-based surfactant and a defoaming agent are disclosed. In particular, the present disclosure provides compositions and methods for providing a sanitizing rinse with desired antimicrobial efficacy against a broad spectrum of gram-negative microbes, suitable foaming profiles, and beneficial applications of use of the same.

Abstract: The disclosure is directed to cleaning compositions, methods of making the cleaning compositions, and methods of using the cleaning compositions. The cleaning compositions comprise an enzyme composition and a nonionic surfactant having an HLB between 10 and 22. Preferably, the enzyme compositions included in the cleaning compositions comprise a cellulase, an AA9 polypeptide having cellulolytic enhancing activity, a hemicellulase, an esterase, an expansin, a laccase, a ligninolytic enzyme, a pectinase, a peroxidase, a protease, a swollenin, or a combination or mixture thereof. The compositions are useful for degradation of bacterial cellulose.

Abstract: Sanitizing cleaning/rinse aid compositions for various applications including institutional machine warewash sanitizing are disclosed. In particular, concentrated and use compositions, such as concentrated liquid rinse aid compositions or ware wash detergents, employing an amine-based surfactant and a defoaming agent are disclosed. In particular, the present disclosure provides compositions and methods for providing a sanitizing rinse with desired antimicrobial efficacy against a broad spectrum of gram-negative microbes, suitable foaming profiles, and beneficial applications of use of the same.

Abstract: The present disclosure relates to a stable, low-foaming enzymatic detergent compositions and methods of making and using the same. In a preferred embodiment, the enzymatic detergent compositions are particularly useful for cleaning medical and dental instruments. In a preferred embodiment, the enzymatic detergent compositions demonstrate stability after storage for at least about 4 weeks and at temperatures greater than room temperature.

Abstract: A first unit configured to generate and transmit a code of positive and negative DC pulses through a first rail of a railway. A second unit spaced from the first unit and configured to sense the code, which includes a leading code word, having a positive or negative timing pulse followed after a first data interval by a positive or negative data pulse, followed by a modifying code word. The modifying code word consists of a second positive or negative timing pulse followed after a second data interval by a second positive or negative data pulse. The second timing pulse starts after one code cycle from the start of the leading code word timing pulse. The second timing pulse and the second data pulse duplicate the timing pulse and the data pulse of the same polarity, but invert the timing pulse and the data pulse of opposite polarities.

Abstract: A system includes a determination module and a communication module. The determination module is configured to be located onboard a first vehicle that travels along a first route including a crossing corresponding to an intersection of the first route with a second route. The determination module is configured to be communicatively coupled with a remote crossing module that is configured to impede travel of a second vehicle through the crossing, and to identify an upcoming stop at a station within a range of a track detection system associated with the remote crossing module. The communication module is configured to communicatively couple the determination module to the remote crossing module, and to transmit an inhibit request message to the remote crossing module. The inhibit request message is configured to prevent the remote crossing module from activating a warning when the first vehicle is stopped at the station.

Abstract: A system includes a determination module and a communication module. The determination module is configured to be located onboard a first vehicle that travels along a first route including a crossing corresponding to an intersection of the first route with a second route. The determination module is configured to be communicatively coupled with a remote crossing module that is configured to impede travel of a second vehicle through the crossing, and to identify an upcoming stop at a station within a range of a track detection system associated with the remote crossing module. The communication module is configured to communicatively couple the determination module to the remote crossing module, and to transmit an inhibit request message to the remote crossing module. The inhibit request message is configured to prevent the remote crossing module from activating a warning when the first vehicle is stopped at the station.

Abstract: A first unit configured to generate and transmit a code of positive and negative DC pulses through a first rail of a railway. A second unit spaced from the first unit and configured to sense the code, which includes a leading code word, having a positive or negative timing pulse followed after a first data interval by a positive or negative data pulse, followed by a modifying code word. The modifying code word consists of a second positive or negative timing pulse followed after a second data interval by a second positive or negative data pulse. The second timing pulse starts after one code cycle from the start of the leading code word timing pulse. The second timing pulse and the second data pulse duplicate the timing pulse and the data pulse of the same polarity, but invert the timing pulse and the data pulse of opposite polarities.

Abstract: An electrical connector comprises an elongate insulative housing having a plurality of cavities extending in side-by-side relation along the longitudinal housing direction. Each of the cavities is nominally spaced for fine pitch applications to be on the order of 0.050 inch. A wire contact assembly which is snapped into the connector housing and resiliently held therein by a releasable latch, comprises an insulation crimping portion that is formed during the crimping process to be of oval configuration. The oval configuration allows the use of wires at least as large as 28 AWG in such fine pitch spacings and permits installation of each wire contact assembly into the connector in the same orientation.

Abstract: There has been provided a burner control system including apparatus adapted for controlling fuel burner systems for firing furnace sections of steam generators in accordance with any one of a plurality of predetermined subsystem specifications such as fuel safety, ignition and shutdown sequences. The system includes a plurality of sets of logical function means (LFM) having inputs and outputs, responsive to selected ones of the parameters of the system for producing output control and indication signals respectively. Each LFM comprises one solid state control circuit card for performing each logical function in accordance with the specification such as fuel trip, burner ignition and shutdown etc. Each control circuit card is fabricated to include functional logic circuits of the AND, OR, NAND, NOR, etc.