Abstract: Compounds of the formula ##STR1## are disclosed, wherein R.sub.1, represents secondary alkyl; aralkyl; cycloalkyl; heteroaryl substituted alkyl; norbornyl; and substituted secondary alkyl, aralkyl, cycloalkyl, heteroaryl substituted alkyl, norbornyl; and para-substituted phenyl groups; and R.sub.2 and R.sub.3 are hydrogen or pharmacologically acceptable acyl groups. The compounds of the invention are useful as cardiovascular vasodilator or anti-hypertensive agents. The therapeutically useful compounds of the invention as well as similar 5'-N and N-6 substituted adenosine 5'-uronamides are prepared, in accordance with a novel process, from isopropylidene (or otherwise suitably blocked) inosine-5' -uronic acid. Isopropylideneinosine-5' -uronic acid is reacted with a suitable inorganic acid halide, such as thionyl chloride, to yield 6-halogeno-9-[ 2',3' -O-isopropylidene-.beta.-D-ribofuranosyl-5-uronic acid halide] -9H-purine. This intermediate is reacted with an amine of the general formula R.sub.4,R.sub.

Abstract: The present invention discloses a compound of the formula: ##STR1## where R.sub.1 is hydrogen or the group ##STR2## where R.sub.3 and R.sub.4 are the same or different and are hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, C.sub.3 to C.sub.7 cycloalkyl, C.sub.6 to C.sub.10 aryl unsubstituted or substituted with C.sub.1 to C.sub.6 linear or branched alkyl, C.sub.1 to C.sub.6 linear or branched alkoxy, nitro, amino, amino substituted with at least one C.sub.1 to C.sub.6 linear or branched alkyl or phenyl, C.sub.2 to C.sub.10 aralkyl, C.sub.4 to C.sub.8 heteroaryl wherein said heteroatom is nitrogen, phosphorous, sulfur or oxygen, and R.sub.2 is hydrogen, or taken together with R.sub.5, forms a chemical bond, and R is a monosaccharide radical selected from the group consisting essentially of glucose, fructose, ribose, 2-deoxyribose, mannose, galactose, xylose and arabinose.

Abstract: A pressure gauge is provided comprising a sensor housing (1) closed by a cover (7). The sensor housing (1) is connected to a tube (3) containing the pressure to be measured. The space defined by the sensor housing (1) and the cover (7) is hermetically divided by a sensor housing cover (9) in such a way that inside a front measurement volume (11) a pressure sensor means (15) is placed. This pressure sensor means has a substantially flat shape. It is connected to the interior walls of the front volume by means of tubes (23) which are slender or slim, that is have a small section in relation to the area of the pressure sensor means (15). The carrying means (23) are preferably realized as metal tubes and in their interior the electrical connections (31) for the pressure sensor means pass. By this construction the exterior surface of the whole of the pressure sensor means (15) will be subjected to the measuring pressure.

Abstract: Compounds are disclosed having the formulae: ##STR1## wherein R.sub.1 is selected from the group, consisting of radicals represented by the general formulae: ##STR2## wherein Y is selected from the group consisting of lower alkyl, lower alkoxy, and halogen; Z is oxygen, sulfur or --NH, Q is --CH or nitrogen; a is zero or an integer of from one to three; andwherein, R.sub.2 is selected from the group consisting of hydrogen and straight chain, branched and cyclic hydrocarbyl radicals having from one to four carbon atoms, and optionally substituted with a hydroxyl radical; andwherein X is two hydrogen atoms or oxygen and B is selected from oxygen and nitrogen, and pharmaceutically acceptable salts thereof, with the proviso that when X is two hydrogen atoms, B is oxygen, and with the further proviso that when B is oxygen then R.sub.1 cannot be a phenyl or a substituted phenyl radical. Pharmaceutical preparations using these compounds and a method for inducing an adenosine response mediated by the adenosine A.sub.

Abstract: A series of 15 N.sup.6 -substituted 9-methyladenines have been assessed as antagonists of A.sub.2 -adenoisine receptor-mediated stimulation of adenylate cyclase in membranes of hman platelets and rat PC12 cells and of A.sub.1 -adenosine receptor-mediated inhibition of adenylate cyclases in membranes of rat fat cells and as inhibitors of binding of N.sup.6 -R-[.sup.3 H]-phenylisopropyladenosine to A.sub.1 adenosine receptors in rat brain membranes.

Abstract: New, N-6 monosubstituted adenosine derivatives are disclosed which have significant cardiac vasodilatory effect. The compounds of the invention include 6-(cyclo-butyl amino)-9-(.beta.-D-ribofuranosyl)-9H-purine, 6-(2-methyl-2-phenyl hydrazino)-9-(.beta.-D-ribofuranosyl)-9H-purine, and compounds of the general formula: ##STR1## wherein R.sub.1 is H, lower alkyl, lower alkoxy, alkylamino, or arylamino, R.sub.2 is H, lower alkyl, hydroxymethyl, phenyl or substituted phenyl, R.sub.3 is H, lower alkyl, phenyl, substituted phenyl, R.sub.3 is H, lower alkyl, phenyl, substituted phenyl, 2 or 3-thienyl, or 2 or 3-pyridyl, R.sub.4 is H or lower alkyl, and R.sub.5 is H or lower acyl. Particularly active as a cardiac vasodilator is the compound (-)-6-(R-1-phenyl-2-butyl amino)-9-(.beta.-D-ribofuranosyl)-9H-purine.

Abstract: A capacity pressure sensor having a housing and a diaphragm. The housing and the diaphragm are substantially flat and are connected to each other at an upstanding border at the periphery of the housing. In the hermetically closed space between the housing and said diaphragm a reference pressure is applied. In a pressure measurement the diaphragm is bent inwards relative to said housing depending on the pressure acting on the surface of said diaphragm. This bending inwards is a primary output signal which capacitively can be converted to an electrical signal. Inside the pressure sensor on the inner surfaces of said housing and said diaphragm there are arranged, for the detection of the position of said diaphragm relative to said housing, capacitor plates connected to an electrical measuring circuit for detection of the capacity of the capacitor formed thereby. To enhance the linearity of the measuring capacitor the outer flat surfaces of the pressure sensor are coated with conducting layers connected to earth.

Abstract: A space is cooled by gasifying or vaporizing a first, preferably liquid substance in a first container located in said space. The gas or vapor thus formed is conducted into a second container located outside the space and containing a second substance generating a lower gas pressure than said first substance at the same temperature, preferably by being chemically bound thereby. Said gas or vapor is absorbed by the second substance, which shall possess the quality of forming a porous, substantially rigid body in its container after heating or regeneration in vacuum. The second substance is comprised of sodium sulphide, at least as its major ingredient.

Abstract: Heat energy is stored chemically in and extracted from an energy accumulator containing a substance which contains less liquid in the charged, high-energy condition of the accumulator than it does in the discharged low-energy condition of the accumulator, which is associated with vapor condensing and generating means which is maintained at a low temperature as compared with the accumulator in which a liquid container is comprised. Vapor is driven off from the accumulator substance and transferred to the vapor condensing and generating means when energy is stored in the accumulator, and is returned to the accumulator when heat energy is extracted therefrom. The system comprising the accumulator and said vapor condensing and generating means is maintained substantially free from other gases than said vapor.